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1.
Chemistry ; 30(35): e202400897, 2024 Jun 20.
Artigo em Inglês | MEDLINE | ID: mdl-38597591

RESUMO

In this work, we present the solid-state structures of solvent-free Ga[pf] and In[pf] salts ([pf]-=[Al(ORF)4]-; RF=C(CF3)3), which are very rare examples of salts with truly 'naked' metal cations. Both salts may serve as starting materials for subvalent gallium and indium chemistry with very weakly coordinating ligands providing the freedom of choice for solvents and ligands for the future. On the other hand, we report and rationalize the formation and isolation of [M(OEt2)2][pf] and [M(MeCN)2][pf] (M=Ga, In), underlining the surprising stability of these subvalent group 13 M+ ions against disproportionation. Unexpectedly, dicoordinate and carbene analogous [M(L)2]+ ions with the [pf]- counterion are stable in L=acetonitrile and diethyl ether at room temperature, opening up possible applications for example in organic synthesis and catalysis.

2.
Angew Chem Int Ed Engl ; 62(47): e202311648, 2023 Nov 20.
Artigo em Inglês | MEDLINE | ID: mdl-37728006

RESUMO

The reaction of bisdicyclohexylphosphinoethane (dcpe) and the subvalent MI sources [MI (PhF)2 ][pf] (M=Ga+ , In+ ; [pf]- =[Al(ORF )4 ]- ; RF =C(CF3 )3 ) yielded the salts [{M(dcpe)}2 ][pf]2 , containing the first dicationic, trans-bent digallene and diindene structures reported so far. The non-classical MI ⇆MI double bonds are surprisingly short and display a ditetrylene-like structure. The bonding situation was extensively analyzed by quantum chemical calculations, QTAIM (Quantum Theory of Atoms in Molecules) and EDA-NOCV (Energy Decomposition Analysis with the combination of Natural Orbitals for Chemical Valence) analyses and is compared to that in the isoelectronic and isostructural, but neutral digermenes and distannenes. The dissolved [{Ga(dcpe)}2 ]2+ ([pf]- )2 readily reacts with 1-hexene, cyclooctyne, diphenyldisulfide, diphenylphosphine and under mild conditions at room temperature. This reactivity is analyzed and rationalized.

3.
J Magn Reson ; 353: 107476, 2023 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-37392588

RESUMO

Nuclear magnetic resonance (NMR) has been instrumental in deciphering the structure of proteins. Here we show that transverse NMR relaxation, through its time-dependent relaxation rate, is distinctly sensitive to the structure of complex materials or biological tissues at the mesoscopic scale, from micrometers to tens of micrometers. Based on the ideas of universality, we show analytically and numerically that the time-dependent transverse relaxation rate approaches its long-time limit in a power-law fashion, with the dynamical exponent reflecting the universality class of mesoscopic magnetic structure. The spectral line shape acquires the corresponding non-analytic power law singularity at zero frequency. We experimentally detect the change in the dynamical exponent as a result of the transition into maximally random jammed state characterized by hyperuniform correlations. The relation between relaxational dynamics and magnetic structure opens the way for noninvasive characterization of porous media, complex materials and biological tissues.

4.
Dalton Trans ; 52(14): 4355-4370, 2023 Apr 04.
Artigo em Inglês | MEDLINE | ID: mdl-36924178

RESUMO

Weakly coordinating anions (WCAs) facilitate the stabilization and isolation of highly reactive and almost "naked" cations. Alkoxyaluminate-based WCAs such as [Al(OC(CF3)3)4]- ([pf]-) are widely used due to their synthetic accessibility and their high stability. However, small cations are still able to coordinate the oxygen atoms of the [pf]- anion or even to abstract an alkoxy ligand. The novel WCA [Al(OC10F15)4]- ([pfAd]-; OC10F15 = perfluoro-1-adamantoxy) is characterized by a very rigid core framework, thus indicating a higher stability towards fluoride-ion abstraction (DFT calculations) and providing hope to generate less disordered crystal structures. The [pfAd]- anion was generated by the reaction of the highly acidic alcohol perfluoro-1-adamantanol C10F15OH with LiAlH4 in o-DFB. Li[pfAd] could not be synthesized free of impurities (and still contains unreacted alcohol). Yet, starting from contaminated Li[pfAd], the very useful pure salts Ag[pfAd], [Ph3C][pfAd] and [H(OEt2)2][pfAd] could be synthesized. The salts were characterized by NMR spectroscopy, single-crystal X-ray diffraction and IR spectroscopy. Additionally, [NO][pfAd] could be synthesized containing alcohol impurities but nonetheless enabled the synthesis of the salt P9+[pfAd]-. The synthesis of Tl[pfAd] in a mixture of H2O/acetone/o-DFB demonstrated the water stability of the [pfAd]- anion.

5.
Chem Commun (Camb) ; 59(10): 1353-1356, 2023 Jan 31.
Artigo em Inglês | MEDLINE | ID: mdl-36648756

RESUMO

Syntheses and characterization of two salts [(L)GaGa(L)][pf]2 ([pf]- = [Al(ORF)4]-; RF = C(CF3)3) are reported. They include the first dicationic digallene [(L)Ga⇆Ga(L)]2+ (L = CDPPh = C(PPh3)2) and a digallane [(L)Ga-Ga(L)]2+ (L = [NacNacMes]-). The CDPPh-supported digallene dication includes a trans-bent [L-GaGa-L]2+ bond that is analogous to neutral R-GaGa-R molecules and related to Robinson's famous "Digallyne" [R-GaGa-R]2-. The dicationic digallane [(L)Ga-Ga(L)]2+ is analogous to the widely used "Jones magnesium dimer", but includes a very short GaII-GaII single bond.

6.
Chemistry ; 28(53): e202201369, 2022 Sep 22.
Artigo em Inglês | MEDLINE | ID: mdl-35695015

RESUMO

The tetracationic, univalent cluster compounds [{M(dmpe)}4 ]4+ (M=Ga, In; dmpe=bis(dimethylphosphino)ethane) were synthesized as their pf salts ([pf]- =[Al(ORF )4 ]- ; RF =C(CF3 )3 ). The four-membered ring in [{M(dmpe)}4 ]4+ is slightly puckered for M=Ga and almost square planar for M=In. Yet, although structurally similar, only the gallium cluster is prevalent in solution, while the indium cluster forms temperature dependent equilibria that include even the monomeric cation [In(dmpe)]+ . This system is the first report of one and the same ligand inducing formation of isoelectronic and isostructural gallium/indium cluster cations. The system allows to study systematically analogies and differences with thermodynamic considerations and bonding analyses, but also to outline perspectives for bond activation using cationic, subvalent group 13 clusters.

7.
Chem Sci ; 13(2): 439-453, 2022 Jan 05.
Artigo em Inglês | MEDLINE | ID: mdl-35126976

RESUMO

Already 1 mol% of subvalent [Ga(PhF)2]+[pf]- ([pf]- = [Al(ORF)4]-, RF = C(CF3)3) initiates the hydrosilylation of olefinic double bonds under mild conditions. Reactions with HSiMe3 and HSiEt3 as substrates efficiently yield anti-Markovnikov and anti-addition products, while bulkier substrates such as HSiiPr3 are less reactive. Investigating the underlying mechanism by gas chromatography and STEM analysis, we unexpectedly found that H2 and metallic Ga0 formed. Without the addition of olefins, the formation of R3Si-F-Al(ORF)3 (R = alkyl), a typical degradation product of the [pf]- anion in the presence of a small silylium ion, was observed. Electrochemical analysis revealed a surprisingly high oxidation potential of univalent [Ga(PhF)2]+[pf]- in weakly coordinating, but polar ortho-difluorobenzene of E 1/2(Ga+/Ga0; oDFB) = +0.26-0.37 V vs. Fc+/Fc (depending on the scan rate). Apparently, subvalent Ga+, mainly known as a reductant, initially oxidizes the silane and generates a highly electrophilic, silane-supported, silylium ion representing the actual catalyst. Consequently, the [Ga(PhF)2]+[pf]-/HSiEt3 system also hydrodefluorinates C(sp3)-F bonds in 1-fluoroadamantane, 1-fluorobutane and PhCF3 at room temperature. In addition, both catalytic reactions may be initiated using only 0.2 mol% of [Ph3C]+[pf]- as a silylium ion-generating initiator. These results indicate that silylium ion catalysis is possible with the straightforward accessible weakly coordinating [pf]- anion. Apparently, the kinetics of hydrosilylation and hydrodefluorination are faster than that of anion degradation under ambient conditions. These findings open up new windows for main group catalysis.

8.
Angew Chem Int Ed Engl ; 59(49): 22023-22027, 2020 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-32776669

RESUMO

The potential of a dicationic strontium ansa-arene complex for Lewis acid catalysis has been explored. The key to its synthesis was a simple salt metathesis from SrI2 and 2 Ag[Al(ORF )4 ], giving the base-free strontium-perfluoroalkoxyaluminate Sr[Al(ORF )4 ]2 (ORF =OC(CF3 )3 ). Addition of an ansa-arene yielded the highly Lewis acidic, dicationic strontium ansa-arene complex. In preliminary experiments, the complex was successfully applied as a catalyst in CO2 -reduction to CH4 and a surprisingly controlled isobutylene polymerization reaction.

9.
Chem Commun (Camb) ; 56(40): 5350-5353, 2020 May 18.
Artigo em Inglês | MEDLINE | ID: mdl-32319467

RESUMO

[(Ph3P)AuPt(nbe)3][BAr4F] (nbe = norbornene) constitutes the first olefin-containing, formal Au+IPt0 complex. The unusual coordination mode and the electronic properties have been analyzed spectroscopically and by calculations. The low binding energy of the nbe ligands make this complex a valuable precursor for formal Au+IPt0 complexes and a candidate for heterobimetallic catalysis.

10.
Inorg Chem ; 59(14): 9496-9510, 2020 Jul 20.
Artigo em Inglês | MEDLINE | ID: mdl-32124602

RESUMO

The PPh3 ligands in the heterodinuclear AuPt complex [(Ph3P)AuPt(PPh3)3][BAr4F] (BAr4F = tetrakis[3,5-bis(trifluoromethyl)phenyl]borate) exhibit a high fluxionality on the AuPt core. Fast intramolecular and slow intermolecular processes for the reversible exchange of the PPh3 ligands have been identified. When [(Ph3P)AuPt(PPh3)3][BAr4F] is heated in solution, the formation of benzene is observed, and a trinuclear, cationic AuPt2 complex is generated. This process is preceded by reversible phenyl-group exchange between the PPh3 ligands present in the reaction mixture as elucidated by deuterium-labeling studies. Both the elimination of benzene and the preceding reversible phenyl-group exchange have originally been observed in mass-spectrometry-based CID experiments (CID = Collision-Induced Dissociation). While CID of mass-selected [Au,Pt,(PPh3)4]+ results exclusively in the loss of PPh3, the resulting cation [Au,Pt,(PPh3)3]+ selectively eliminates C6H6. Thus, the dissociation of a PPh3 ligand from [Au,Pt,(PPh3)3]+ is energetically not able to compete with processes which result in C-H- and C-P-bond cleavage. In both media, the heterobimetallic nature of the employed complexes is the key for the observed reactivity. Only the intimate interplay of the gas-phase investigations, studies in solution, and thorough DFT computations allowed for the elucidation of the mechanistic details of the reactivity of [(Ph3P)AuPt(PPh3)3][BAr4F].

11.
Chem Commun (Camb) ; 56(30): 4160-4163, 2020 Apr 14.
Artigo em Inglês | MEDLINE | ID: mdl-32211654

RESUMO

Pyridyllithiums are ubiquitous intermediates used for the electrophilic functionalization of pyridines. In this work, the isolation of a pyridyllithium is reported. Single crystal XRD revealed a dimer in the solid state. In THF solution it was identified as a monomer using DOSY NMR spectroscopy. Calculations showed that the pyridyllithium is a very electron rich pyridine superbase, which may account for its high reactivity.

12.
Chemphyschem ; 20(19): 2408-2412, 2019 10 02.
Artigo em Inglês | MEDLINE | ID: mdl-31479580

RESUMO

Molecular hydrogen has unique nuclear spin properties. Its nuclear spin isomer, parahydrogen (pH2 ), was instrumental in the early days of quantum mechanics and allows to boost the NMR signal by several orders of magnitude. pH2- induced polarization (PHIP) is based on the survival of pH2 spin order in solution, yet its lifetime has not been investigated in aqueous or biological media required for in vivo applications. Herein, we report longitudinal relaxation times (T1 ) and lifetimes of pH2 ( τPOC ) in methanol and water, with or without O2 , NaCl, rhodium-catalyst or human blood. Furthermore, we present a relaxation model that uses T1 and τPOC for more precise theoretical predictions of the H2 spin state in PHIP experiments. All measured T1 values were in the range of 1.4-2 s and τPOC values were of the order of 10-300 minutes. These relatively long lifetimes hold great promise for emerging in vivo implementations and applications of PHIP.


Assuntos
Hidrogênio/sangue , Hidrogênio/química , Humanos , Hidrogênio/análise , Soluções , Água/química
13.
Angew Chem Int Ed Engl ; 58(40): 14162-14166, 2019 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-31369694

RESUMO

The reaction of the Ga+ source [Ga(PhF)2 ]+ [Al(ORF )4 ]- with the neutral σ-donor ligand dmap (4-Me2 N-C6 H4 N) produces the unexpectedly large and fivefold positively charged cluster cation salt [Ga5 (dmap)10 ]5+ ([Al(ORF )4 ]- )5 . It includes a regular and planar Ga5 pentagon with strong metal-metal bonding. Additionally, the compound represents the first salt in which an ionic 1:5 packing is realized. We discuss the nature of this structure which results from the conversion of the non-bonding 4s2 lone-pair orbitals into fully Ga-Ga-bonding orbitals and the solid-state arrangement of the ions constituting the lattice as an almost orthohexagonal AX5 lattice, possibly the aristotype of any 5:1 salt.

14.
Chemistry ; 25(52): 12159-12168, 2019 Sep 18.
Artigo em Inglês | MEDLINE | ID: mdl-31287589

RESUMO

The complexes Ag(L)n [WCA] (L=P4 S3 , P4 Se3 , As4 S3 , and As4 S4 ; [WCA]=[Al(ORF )4 ]- and [F{Al(ORF )3 }2 ]- ; RF =C(CF3 )3 ; WCA=weakly coordinating anion) were tested for their performance as ligand-transfer reagents to transfer the poorly soluble nortricyclane cages P4 S3 , P4 Se3 , and As4 S3 as well as realgar As4 S4 to different transition-metal fragments. As4 S4 and As4 S3 with the poorest solubility did not yield complexes. However, the more soluble silver-coordinated P4 S3 and P4 Se3 cages were transferred to the electron-poor Fp+ moiety ([CpFe(CO)2 ]+ ). Thus, reaction of the silver salt in the presence of the ligand with Fp-Br yielded [Fp-P4 S3 ][Al(ORF )4 ] (1 a), [Fp-P4 S3 ][F(Al(ORF )3 )2 ] (1 b), and [Fp-P4 Se3 ][Al(ORF )4 ] (2). Reactions with P4 S3 also yielded [FpPPh3 -P4 S3 ][Al(ORF )4 ] (3), a complex with the more electron-rich monophosphine-substituted Fp+ analogue [FpPPh3 ]+ ([CpFe(PPh3 )(CO)]+ ). All complex salts were characterized by single-crystal XRD, NMR, Raman, and IR spectroscopy. Interestingly, they show characteristic blueshifts of the vibrational modes of the cage, as well as structural contractions of the cages upon coordination to the Fp/FpPPh3 moieties, which oppose the typically observed cage expansions that lead to redshifts in the spectra. Structure, bonding, and thermodynamics were investigated by DFT calculations, which support the observed cage contractions. Its reason is assigned to σ and π donation from the slightly P-P and P-E antibonding P4 E3 -cage HOMO (e symmetry) to the metal acceptor fragment.

15.
Chemistry ; 25(45): 10546-10551, 2019 Aug 09.
Artigo em Inglês | MEDLINE | ID: mdl-31066932

RESUMO

Upon coordinating P4 to electron poor cyclopentadienyl-iron cations, the average P-P bond distances shrink and the respective P4 breathing mode in the Raman spectra (600 cm-1 , P4, free ) is blueshifted by >40 cm-1 in [CpFe(CO)(L)(η1 -P4 )]+ cations (L=CO or PPh3 ). Analysis suggests that this corresponds to an umpolung of the bonding from more phosphidic in the known, electron-rich systems to more phosphonium-like in the reported electron-poor versions. This may open new functionalization pathways for white phosphorus P4 .

16.
Chem Sci ; 10(9): 2821-2829, 2019 Mar 07.
Artigo em Inglês | MEDLINE | ID: mdl-30997003

RESUMO

Instead of yielding the desired non-classical silylium ions, the reactions of different alkenes/alkynes with several [Me3Si]+ sources mostly led to oligomerization, or - in the presence of Me3SiH - hydrosilylation of the alkenes/alkynes. Yet, from the reaction of 2-butyne with ion-like Me3Si-F-Al(ORF)3 (RF = C(CF3)3) the salt of the silylated tetramethyl cyclobutenyl cation [Me4C4-SiMe3]+[al-f-al]- 1 ([al-f-al]- = [(RFO)3Al-F-Al(ORF)3]-) was obtained in good yield (NMR, scXRD, Raman, and IR). All the experimental and calculated evidence suggest a mechanism in which 1 was formed via a non-classical silylium ion as an intermediate. The removal of the [Me3Si]+ moiety from the cation in 1 was investigated as a means to provide free tetramethyl cyclobutadiene (CBD). However, the addition of [NMe4]F, in order to release Me3SiF and form CBD, led to the unexpected deprotonation of the cation. The addition of 4-dimethylaminopyridine to remove the [Me3Si]+ cation as a Lewis acid/base adduct, led to an adduct with the four-membered ring in the direct neighborhood of the Me3Si group. By the addition of Et2O to a solution of 1, the [F-Al(ORF)3]- anion (and Et2O-Al(ORF)3) was generated from the [al-f-al]- counterion. Subsequently, the [F-Al(ORF)3]- anion abstracted the [Me3Si]+ moiety from [Me4C4-SiMe3]+, probably releasing CBD. However, due to the immediate reaction of CBD with [Me4C4-SiMe3]+ and subsequent oligomerization, it was not possible to use CBD in follow-up chemistry.

17.
Chem Sci ; 10(46): 10779-10788, 2019 Dec 14.
Artigo em Inglês | MEDLINE | ID: mdl-32055385

RESUMO

Condensed phase access to the unprecedented tetrahedral cations [EP3]+ (E = S, Se, Te) was achieved through the reaction of ECl3[WCA] with white phosphorus ([WCA]- = [Al(ORF)4]- and [F(Al(ORF)3)2]-; -RF = -C(CF3)3). Previously, [EP3]+ was only known from gas phase MS investigations. By contrast, the reaction of ECl3[A] with the known P3 3- synthon Na[Nb(ODipp)3(P3)] (enabling AsP3 synthesis), led to formation of P4. The cations [EP3]+ were characterized by multinuclear NMR spectroscopy in combination with high-level quantum chemical calculations. Their bonding situation is described with several approaches including Atoms in Molecules and Natural Bond Orbital analysis. The first series of well-soluble salts ECl3[WCA] was synthesized and fully characterized as starting materials for the studies on this elusive class of [EP3]+ cations. Yet, with high [ECl3]+ fluoride ion affinity values between 775 (S), 803 (Se) and 844 (Te) kJ mol-1, well exceeding typical phosphenium ions, these well-soluble ECl3[WCA] salts could be relevant in view of the renewed interest in strong (also cationic) Lewis acids.

18.
Org Biomol Chem ; 16(40): 7503-7512, 2018 10 17.
Artigo em Inglês | MEDLINE | ID: mdl-30276385

RESUMO

The bifunctional chelator NODIA-Me holds promise for radiopharmaceutical development. NODIA-Me is based on the macrocycle TACN (1,4,7-triazacyclononane) and incorporates two additional methylimidazole arms for metal chelation and an acetic acid residue for bioconjugation. The original two step synthesis was less than optimal due to low yields and the requirement of semi-preparative RP-HPLC purifications. Here, the overall yield for the preparation of NODIA-Me was improved two- to five-fold via two synthetic routes using different protection/deprotection techniques. This way, it was possible (1) to prepare of NODIA-Me on multi-gram scale and (2) to avoid time-consuming HPLC purifications. Inspired by recent results with nat/68Ga3+, preliminary studies on the radiolabeling properties and complex formation of NODIA-Me with nat/111In3+ were performed. Quantitative radiochemical yields were achieved at ambient temperature providing molar activities of ∼30 MBq nmol-1, which could be increased to ∼240 MBq nmol-1 at 95 °C. At r.t., pH 5.5 was optimal for 111In-labeling, but quantitative yields were also achieved in the pH range from 5.5 to 8.2, when the reaction temperature was increased. Stability tests of 111In complexes in vitro revealed high kinetic stabilities in serum and ligand challenge experiments, which is a consequence of the formation of rigid 1 : 1 indium chelates as shown by NMR studies in solution. In summary, the new synthetic routes afford the BFC NODIA-Me in high yields and on large scale. Further, 111In complexation experiments broaden the scope of our chelating system for radiopharmaceutical applications.


Assuntos
Quelantes/química , Complexos de Coordenação/química , Complexos de Coordenação/síntese química , Imidazóis/química , Índio/química , Técnicas de Química Sintética , Interações Hidrofóbicas e Hidrofílicas , Marcação por Isótopo , Cinética , Ligantes
19.
Chem Sci ; 9(35): 7058-7068, 2018 Sep 21.
Artigo em Inglês | MEDLINE | ID: mdl-30310626

RESUMO

By reaction of the Lewis acid Me3Si-F-Al(ORF)3 with a series of [PF6]- salts, gaseous PF5 and Me3Si-F are liberated and salts of the anion [F-Al(ORF)3]- ([f-al]-; RF = C(CF3)3) can be obtained. By addition of another equivalent of Me3Si-F-Al(ORF)3 to [f-al]-, gaseous Me3Si-F is released and salts of the least coordinating anion [(RFO)3Al-F-Al(ORF)3]- ([al-f-al]-) are formed. Both procedures work for a series of synthetically useful cations including Ag+, [NO]+, [Ph3C]+ and in very clean reactions with 5 g batch sizes giving excellent yields typically exceeding 90%. In addition, the synthesis of Me3Si-F-Al(ORF)3 has been optimized and scaled up to 85 g batches in an one-pot procedure. These anions could previously only be obtained by difficult to control decomposition reactions of [Al(ORF)4]- or by halide abstraction reactions with Me3Si-F-Al(ORF)3, generating relatively large countercations that are unsuited for further use as universal starting materials. Especially [al-f-al]- is of interest for the stabilization of reactive cations, since it is even weaker coordinating than [Al(ORF)4]- and more stable against strong electrophiles. This bridged anion can be seen as an adduct of [f-al]- and Al(ORF)3. Thus, it is similarly Lewis acidic as BF3 and eventually reacts with nucleophiles (Nu) from the reaction environment to yield Nu-Al(ORF)3 and [f-al]-. This prevents working with [al-f-al]- salts in ethereal or other donor solvents. By contrast, the [f-al]- anion is no longer Lewis acidic and may therefore be used for reactions involving stronger nucleophiles than the [al-f-al]- anion can withstand. Subsequently it may be transformed into the [al-f-al]- salt by simple addition of one equivalent of Me3Si-F-Al(ORF)3.

20.
Chem Commun (Camb) ; 54(72): 10036-10039, 2018 Sep 06.
Artigo em Inglês | MEDLINE | ID: mdl-30063051

RESUMO

While it is often longed for very gentle oxidising agents with ideally close to no interaction with the generated substrate, it may sometimes be beneficial to have an oxidising agent at hand which is able to stabilise a reactive species directly after its generation. Here we present the synthesis of the hexamethylbenzene radical cation as a ligand forming oxidising agent. Its utility was demonstrated by the exemplarily chosen access to the mono-arene complex-cations of univalent gallium and indium [M(C6Me6)]+[Al(ORF)4]- (M = Ga and In).

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