1.
Antimicrob Agents Chemother
; 44(6): 1701-4, 2000 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-10817733
RESUMO
A mutant of Mycobacterium smegmatis has been isolated that is simultaneously resistant to both D-cycloserine (D-CS) and vancomycin. Genetic complementation with a PBP4 homolog restores sensitivity to both drugs. Resistance to D-CS and vancomycin in this mutant is most likely due to a novel mechanism involving peptidoglycan assembly at the cell surface.