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1.
Otol Neurotol ; 34(7): 1278-83, 2013 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-23921941

RESUMO

OBJECTIVES: Cochlear implantation (CI) is the treatment of choice in bilateral labyrinthitis ossificans (LO). The aim of this clinical case study was to evaluate audiologic and subjective outcomes after CI treatment for unilateral hearing loss (UHL) because of LO and to identify optimal timing for treatment. PATIENTS: Three subjects (age 40, 54, and 68 yr) with UHL because of LO were enrolled. Duration of deafness was 1.5, 12, and 120 months. INTERVENTION: After extensive consultation, testing with conventional contralateral routing of signal hearing aid and bone-anchored hearing instrument, CI candidacy was confirmed and CI surgery performed. MAIN OUTCOME MEASURES: Test of open-set speech recognition in background noise and sound localization were performed preoperatively, in unaided and aided conditions, and in the CI-aided condition, at 6 and 12 months postoperatively. Subjective assessment via the Speech, Spatial and Qualities scale (SSQ) and the Tinnitus Visual Analogue Scale was performed at preimplant and 12 months postimplant. CONCLUSION: The data show moderate-to-high hearing benefit after CI in 2 cases and no benefit for the third. SSQ and tinnitus scales show benefit from CI use in both cases. CI treatment should be performed as early as possible, ideally before signs of obliteration are evident. Counseling on all rehabilitation options is important.


Assuntos
Implante Coclear , Perda Auditiva Unilateral/reabilitação , Labirintite/complicações , Labirintite/cirurgia , Ossificação Heterotópica/complicações , Ossificação Heterotópica/cirurgia , Adulto , Idoso , Audiometria de Tons Puros , Implantes Cocleares , Falha de Equipamento , Feminino , Perda Auditiva Súbita/reabilitação , Perda Auditiva Unilateral/etiologia , Perda Auditiva Unilateral/cirurgia , Humanos , Doença de Lyme/complicações , Imageamento por Ressonância Magnética , Masculino , Processo Mastoide/cirurgia , Mastoidite/etiologia , Mastoidite/cirurgia , Pessoa de Meia-Idade , Zumbido/etiologia , Tomografia Computadorizada por Raios X , Resultado do Tratamento
2.
Otol Neurotol ; 34(6): 1064-70, 2013 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-23856626

RESUMO

OBJECTIVE: To evaluate and compare the benefit of a bone-anchored hearing implant with 2 different sound processors in adult patients with unilateral severe to profound sensorineural hearing loss (UHL). STUDY DESIGN: Prospective crossover design. SETTING: Tertiary referral center. PATIENTS: Eleven adults with UHL and normal hearing in the contralateral ear were assigned to 2 groups. INTERVENTION: All subjects were unilaterally implanted with a bone-anchored hearing implant and were initially fitted with 2 different sound processors (SP-1 and SP-2). SP-1 is a multichannel device equipped with an omnidirectional microphone and relatively simple digital signal-processing technology and provides a user-adjustable overall gain and tone control with compression limiting. SP-2 is a fully channel-by-channel programmable device, which can be set with nonlinear dynamic range compression or linear amplification. In addition, SP-2 features automatic noise management, an automatic multichannel directional microphone, microphone position compensation, and an implementation of prescription rules for different types of hearing losses, one of them unilateral deafness. After at least 1-month use of the initial processor, both groups were fitted with the alternative processor. MAIN OUTCOME MEASURES: Speech discrimination in noise and localization tests were performed at baseline visit before surgery, after at least 1-month use of the initial processor, and after at least 2-week use of the alternative processor. RESULTS: Relative to unaided baseline, SP-2 enabled significantly better overall speech discrimination results, whereas there was no overall improvement with SP-1. There was no difference in speech discrimination between SP-1 and SP-2 in all spatial settings. Sound localization was comparably poor at baseline and with both processors but significantly better than chance level for all 3 conditions. CONCLUSION: Patients with UHL have an overall objective benefit for speech discrimination in noise using a bone-anchored hearing implant with SP-2. In contrast, there is no overall objective benefit from SP-1. Depending on the speech-in-noise presentation setting, the difference between objective benefit from SP-2 and SP-1 might be mainly attributed to the new technological features in SP-2 unavailable in SP-1 such as 1) automatic noise management reducing the noise in the speech signal and thus improving the signal-to-noise ratio of the resulting signal on the better ear, 2) programmable multichannel sound-processing and nonlinear dynamic range compression offering considerably greater control over signal amplification compared to SP-1, and 3) implementation of a prescription rule for unilateral deafness addressing the specific amplification needs of patients with UHL by reducing amplification in the low frequencies and applying additional gain in the high frequencies. Sound localization is poor but better than chance level in the unaided condition as well as in both bone-anchored hearing system-aided conditions.


Assuntos
Auxiliares de Audição , Perda Auditiva Neurossensorial/psicologia , Perda Auditiva Neurossensorial/terapia , Ruído , Localização de Som/fisiologia , Testes de Discriminação da Fala , Percepção da Fala/fisiologia , Estimulação Acústica , Adulto , Idoso , Audiometria de Tons Puros , Estudos Cross-Over , Sinais (Psicologia) , Interpretação Estatística de Dados , Feminino , Lateralidade Funcional/fisiologia , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Âncoras de Sutura
3.
Otol Neurotol ; 34(1): 53-60, 2013 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-23202150

RESUMO

OBJECTIVES: Recently, several studies have shown that a cochlear implant is a suitable treatment for hearing rehabilitation of adults with unilateral sensorineural hearing loss (UHL), and benefits for speech comprehension in noise and localization have been demonstrated. The aim of this clinical study was to evaluate the benefit of cochlear implantation in children with UHL in comparison to their unaided listening situation. STUDY DESIGN: Prospective repeated measures single subject design. SETTING: Tertiary referral center; cochlear implant (CI) program PATIENTS: Three children (4, 10, and 11 yr) with noncongenital UHL resulting from different causes were enrolled in the study. INTERVENTION: After extensive consultation with each family and confirming CI-candidacy, each child received a cochlear implant. MAIN OUTCOME MEASURES: Open set speech recognition measures in competing background noise and tests of sound localization were performed for unaided preoperative and CI-aided postimplant intervals after 6 and 12 months. The parent and child versions of the Speech, Spatial and Qualities scale (SSQ) were used for subjective evaluation of hearing at preimplant and 12-month postimplant intervals. CONCLUSION: All children consistently use their CI 1 year postimplant. Our preliminary results suggest binaural hearing benefits for speech understanding in noise, localization ability and subjectively perceived hearing ability for school-aged children with UHL. Trends for CI-benefits in younger preschoolaged children are confirmed through subjective assessment reported by the parents. The benefits in hearing performance suggest binaural integration and processing of electric and acoustic stimulation arriving at 2 different ears is possible for children with UHL.


Assuntos
Implante Coclear , Perda Auditiva Neurossensorial/cirurgia , Perda Auditiva Unilateral/cirurgia , Audição/fisiologia , Percepção da Fala/fisiologia , Criança , Pré-Escolar , Perda Auditiva Neurossensorial/fisiopatologia , Perda Auditiva Unilateral/fisiopatologia , Testes Auditivos , Humanos , Localização de Som/fisiologia
4.
Cochlear Implants Int ; 13(1): 60-4, 2012 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-22340754

RESUMO

We describe for the first time localized necrotizing meningoencephalitis as the cause of functional hearing loss, facial nerve palsy, and vertigo after cochlear implant (CI) surgery. Magnet resonance imaging (MRI) and computed tomography scans before CI surgery and after 3 years showed no abnormalities, especially no evidence of a tumor in the cerebellopontine angle (CPA). Due to recurrent facial nerve palsy the CI was explanted after 5 years in order to be able to visualize the CPA without artifacts caused by the CI in MRI scans. The MRI scans now showed a tumor in the CPA. Following removal of the tumor, histopathological and immunohistochemical examination revealed a necrotizing meningoencephalitis, with the CI electrode as the focus.


Assuntos
Implante Coclear/efeitos adversos , Implantes Cocleares/efeitos adversos , Perda Auditiva Bilateral/cirurgia , Meningoencefalite/diagnóstico , Meningoencefalite/etiologia , Neuroma Acústico/diagnóstico , Implante Coclear/métodos , Diagnóstico Diferencial , Paralisia Facial/diagnóstico , Paralisia Facial/etiologia , Feminino , Seguimentos , Perda Auditiva Bilateral/diagnóstico , Humanos , Imageamento por Ressonância Magnética/métodos , Meningoencefalite/patologia , Meningoencefalite/terapia , Pessoa de Meia-Idade , Necrose/patologia , Neuroma Acústico/patologia , Neuroma Acústico/cirurgia , Medição de Risco , Índice de Gravidade de Doença , Fatores de Tempo , Tomografia Computadorizada por Raios X/métodos , Resultado do Tratamento
5.
Otol Neurotol ; 32(4): 690-4, 2011 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-21555964

RESUMO

BACKGROUND: Hearing loss affects 1 to 3 in 1,000 newborns, with 50% of these cases because of genetic causes. The majority of these are nonsyndromic (70%), and 2% are X linked. So far, 6 different X-linked loci have been mapped, but the causative gene POU3F4 has been identified only for the Locus DFN3. Clinical features of DFN3 often include a mixed, progressive hearing loss, temporal bone anomalies, and stapes fixation. POU3F4 belongs to a subfamily of transcription factors, which are characterized by 2 conserved deoxyribonucleic acid-binding domains, a POU and a HOX domain, both helix-turn-helix structural deoxyribonucleic acid-binding motifs.Several reports have described mutations of POU3F4 in patients with hearing loss and temporal bone abnormalities. In this study, we describe the clinical features and genetic analysis of a male child from a German family with congenital deafness and a novel POU3F4 mutation. METHOD: Mutational analysis of the affected individual and first-degree relatives was performed using direct sequencing of the coding exon and intron transitions of POU3F4. RESULT: The patient (II-1) had profound hearing loss, a severely dysplastic cochlea, and cerebrospinal fluid gusher during cochlear implantation. Sequence analysis of all family members demonstrated a novel missense mutation at nucleotide position 973, thymine to adenine (c.973 T>A), p.W325R in the patient (II-1), the mother (I-2), and sisters (II-2, II-3) heterozygous. The father (I-1) is not a carrier of the mutation. Conservation of the affected amino acid residue was seen across a number of different species. CONCLUSION: We identified a novel mutation in the third helix of the HOX domain of the POU3F4 transcription factor associated with congenital hearing loss.


Assuntos
Perda Auditiva Bilateral/genética , Perda Auditiva Neurossensorial/genética , Fatores do Domínio POU/genética , Criança , Análise Mutacional de DNA , Humanos , Masculino , Mutação
6.
Otol Neurotol ; 32(1): 39-47, 2011 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-21068690

RESUMO

OBJECTIVE: Up to now, treatment modalities of unilateral deafness consist of no treatment, conventional contralateral routing of signal (CROS), or Bone-Anchored Hearing Aid (BAHA) hearing aid. Cochlear implantation makes a new treatment modality available for patients with single-sided deafness. The aim of this study is to evaluate the use of unilateral electrical stimulation with normal hearing on the contralateral side after a period of 6 months compared with the preoperative unaided situation, conventional CROS, or BAHA hearing aids. STUDY DESIGN: Prospective design. SETTING: Tertiary referral center; cochlear implant (CI) program. PATIENTS: Eleven adult subjects with unilateral deafness of various causes were enrolled in the study. Only those patients were included in whom therapy with CROS hearing aid or BAHA was not successful and in whom the auditory nerve was found to be intact and the cochlea patent for cochlear implantation. INTERVENTION: All subjects were fitted in random order with a BAHA Intenso mounted on the softband/tension clamp or with a CROS hearing aid. After test periods with both devices, the subjects received a CI. MAIN OUTCOME MEASURES: The Hochmair-Schulz-Moser sentence test and the Oldenburg sentence test were used to test speech comprehension in 3 presentation configurations in the unaided situation, with conventional CROS and BAHA hearing aids before cochlear implantation as well as after 6 months with CI. Localization was assessed using an array of 7 speakers at head level in a frontal semicircle. Subjective improvement in daily life was evaluated using the Speech, Spatial and Qualities of Hearing Scale, the Health Utilities Index 3 and the International Outcome Inventory for Hearing Aids questionnaires. Tinnitus distress was measured with a tinnitus scale before and after CI implantation. RESULTS: The results show significant improvement in localization ability as well as in speech comprehension in most presentation configurations with the CI. Especially, there is no negative effect on speech comprehension if the noise is presented to the CI ear and speech to the normal hearing ear. With the CI, the summation and squelch effects are not significant, but a significant combined head shadow effect is seen. Speech, Spatial and Qualities of Hearing results show an overall benefit of wearing the CI compared with the other treatment options. The tinnitus scale revealed a positive effect of CI stimulation in cases of preoperative tinnitus. CONCLUSION: The results in these patients suggest that cochlear implantation improves hearing abilities in people with single-sided deafness and is superior to the alternative treatment options. The use of the CI does not interfere with speech understanding in the normal hearing ear. Our data suggest that the binaural integration of electric and acoustic stimulation is possible even with unilateral normal hearing.


Assuntos
Implante Coclear , Perda Auditiva Unilateral/cirurgia , Localização de Som , Percepção da Fala , Zumbido/cirurgia , Estimulação Acústica , Adulto , Idoso , Implantes Cocleares , Humanos , Pessoa de Meia-Idade , Estudos Prospectivos , Testes de Discriminação da Fala , Inquéritos e Questionários , Resultado do Tratamento
7.
Am J Med Genet A ; 152A(7): 1798-802, 2010 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-20583176

RESUMO

About one to three of a 1,000 neonates are afflicted at birth with a serious hearing impairment, with about half of the cases due to genetic causes. Genetic causes of hearing impairment are very heterogeneous. About half of all cases of genetically caused nonsyndromic hearing loss can be ascribed to mutations in the GJB2 gene (connexin 26) and to deletions in the GJB6 gene(connexin 30). Thus far, about 90 different mutations have been identified in the GJB2 gene, of which the majority are autosomal recessive. Ten mutations are autosomal dominant and are in most cases associated with various skin diseases: the keratitis-ichthyosis-deafness (KID) syndrome, Vohwinkel syndrome and palmoplantar keratoderma with deafness. To date, the following mutations have been identified which lead to the Palmoplantar Keratoderma syndrome with deafness; Gly59Ala, Gly59Arg, His73Arg, Arg75Trp, and Arg75Gln. We are reporting on four patients with severe hearing impairment. They are members of three unrelated families, who are carriers of mutations Arg75Trp or Arg75Gln, but unlike patients of other publications, do not all present with Palmoplantar Keratoderma syndrome. Our investigations document additional evidence for the correlation between the cited mutations in the GJB2 gene and a syndromic hearing impairment with palmoplantar keratoderma.


Assuntos
Conexinas/genética , Surdez/complicações , Surdez/genética , Heterogeneidade Genética , Ceratodermia Palmar e Plantar/complicações , Ceratodermia Palmar e Plantar/genética , Mutação/genética , Adulto , Sequência de Aminoácidos , Substituição de Aminoácidos/genética , Sequência de Bases , Conexina 26 , Conexinas/química , Análise Mutacional de DNA , Família , Feminino , Genes Dominantes/genética , Humanos , Lactente , Recém-Nascido , Masculino , Dados de Sequência Molecular , Linhagem , Gravidez , Pele/patologia , Síndrome
8.
Otol Neurotol ; 31(2): 210-5, 2010 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-20101161

RESUMO

OBJECTIVE: Keratitis-ichthyosis-deafness (KID) syndrome is a rare congenital disorder, characterized by hyperkeratosis and erythrokeratoderma associated with profound sensorineural hearing loss. Additional concomitant phenomena of the KID syndrome are dystrophic nails, dental abnormalities, scarring alopecia, and vascularizing keratitis. The disorder is caused by mutation in the GJB2 gene (connexin-26), a gap junction protein. The aim of this study was to explore the feasibility and procedure of cochlear implantation in patients with KID syndrome and to assess the genetic causes. STUDY DESIGN: Retrospective case review. SETTING: Tertiary referral center. Cochlear implant program. PATIENTS: We report on 2 cases of KID syndrome with congenital profound hearing loss. A 50-year-old woman with skin necrosis and implant extrusion 5 years after cochlear implantation and a 10-month-old infant girl with bilateral deafness, alopecia, bright light sensitivity, and congenital dermatosis. INTERVENTION: Genetic analysis. Cochlear implantation. MAIN OUTCOME MEASURES: Mutation analysis, surgical suitability, and hearing rehabilitation. RESULTS: We detected a novel heterozygous missense mutation (Ile30Asn) in Patient 1 and a de novo mutation (Asp50Asn) in the GJB2 gene (connexin-26) in Patient 2. To decrease the risk of skin flap necrosis, we describe alternative surgical cochlear implantation techniques with a novel very thin receiver/stimulator (Nucleus CI 513; Cochlear Corp.). The postoperative course of both patients has been without any problems until now. CONCLUSION: The combination of the cutaneous lesions with visual and auditory impairment demands to diagnose impaired hearing as early as possible. It would be helpful to search for KID syndrome in dealing with patients with deafness, skin lesions of unknown cause, and wound healing problems to choose the right method of surgical treatment and subsequent aftercare.


Assuntos
Implante Coclear , Conexinas/genética , Surdez/genética , Ictiose/genética , Ceratite/genética , Mutação/fisiologia , Conexina 26 , Análise Mutacional de DNA , Surdez/patologia , Surdez/cirurgia , Feminino , Auxiliares de Audição , Perda Auditiva Bilateral/genética , Perda Auditiva Bilateral/patologia , Humanos , Ictiose/patologia , Lactente , Ceratite/patologia , Pessoa de Meia-Idade , Mutação de Sentido Incorreto/genética , Mutação de Sentido Incorreto/fisiologia , Transtornos de Fotossensibilidade/genética , Transtornos de Fotossensibilidade/patologia , Reação em Cadeia da Polimerase Via Transcriptase Reversa , Couro Cabeludo/patologia , Síndrome
9.
Otol Neurotol ; 31(1): 67-73, 2010 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-19841601

RESUMO

OBJECTIVE: The CHARGE syndrome is associated with ear anomalies and deafness in addition to other malformations. Deformations of the ossicles or aplasia of the semicircular canals, cochlear hypoplasia, hypoplasia or aplasia of the VIIIth cranial nerve and abnormal routing of the VIIth cranial nerve, sigmoid sinus, and emissaries are typical findings. The aim of this study is to explore the feasibility and procedure of cochlear implantation in patients with CHARGE syndrome and to assess the outcome. STUDY DESIGN: Retrospective case review. SETTING: Tertiary referral center; cochlear implant program. PATIENTS: Ten patients with CHARGE syndrome and 3 patients with CHARGE-like syndrome treated in our center due to hearing impairment. Eleven patients were congenitally deaf, 1 patient had progressive hearing loss, and 1 patient had mixed hearing loss. INTERVENTION: Computed tomography of temporal bones and magnetic resonance imaging of the brain; bone-anchored hearing aid surgery, cochlear implantation, rehabilitation results. MAIN OUTCOME MEASURES: Surgical suitability and hearing rehabilitation. RESULTS: We illustrate the management of preoperative diagnostics, surgical planning, and hearing rehabilitation. One patient with mixed hearing loss underwent bilateral bone-anchored hearing aid surgery. Because 2 patients had bilateral aplasia of the auditory nerves, we recommended an auditory brainstem implant. The unilateral cochlear implantation was performed in 9 patients and bilateral in 1 patient. In selected cases, it was helpful to plan the operation using a simulator for temporal bone surgery. Complex malformations, such as in CHARGE syndrome, with an increased intraoperative risk for complications should be facilitated by using intraoperative digital volume tomography-assisted navigation and intraoperative digital volume tomography control of electrode position. The results after CI surgery vary due to the differing extent of additional disabilities such as developmental delay, intellectual delay, and visual impairment. Nine of our patients showed improved responsiveness with the cochlear implant. Open speech comprehension could not be observed in 8 patients, whereas the follow-up period was less than 1 year in 4 patients. The relatively high age of our patients at implantation might be an important factor. CONCLUSION: Careful planning of the treatment of CHARGE syndrome patients with sensorineural hearing loss can, to a limited extent, lead to auditory benefit without increasing surgical complications. Cochlear implantation is therefore indicated after critical assessment.


Assuntos
Anormalidades Múltiplas/cirurgia , Implante Coclear , Orelha Interna/cirurgia , Transtornos da Audição/cirurgia , Anormalidades Múltiplas/diagnóstico por imagem , Adolescente , Adulto , Audiometria , Criança , Pré-Escolar , Implantes Cocleares , Orelha Interna/diagnóstico por imagem , Feminino , Transtornos da Audição/diagnóstico por imagem , Humanos , Lactente , Imageamento por Ressonância Magnética , Masculino , Radiografia , Síndrome , Resultado do Tratamento
11.
Clin Res Cardiol ; 98(2): 94-100, 2009 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-18975024

RESUMO

BACKGROUND: Cardiac troponins are the preferred biomarkers to predict infarct size in patients (pts) after acute myocardial infarction (AMI). Less information is currently available to verify the prognostic value of such a biomarker surrogate. METHODS: We included 82 pts with acute STEMI and compared all single time point and serial cardiac troponin T (cTnT) values (peak and area-under-the-curve) from admission until day 4 to predict future major adverse cardiac events (MACE). RESULTS: Pts who had suffered any MACE during follow-up had higher cTnT values (median (25th/75th percentiles) on day 4 (3.16 microg/l (2.71/5.20) Vs. 2.1 microg/l (1.19/3.96), P=0.0304), and higher peak cTnT values (5.11 microg/l (3.31/9.47) Vs. 2.92 microg/l (1.81/5.63), P=0.0234). The likelihood to develop a composite of MACE was twofold higher in the intermediate cTnT tertile (1.66-3.04 microg/l, n=23), and in the upper cTnT tertile (3.35-20.68 microg/l, n=23) for cTnT on day 4. For cTnT peak the risk was 1.7-fold higher in the intermediate cTnT peak tertile (2.55-5.01 microg/l, n=28) and 2.4-fold in the upper cTnT peak tertile (5.11-18.93 microg/l, n=27). The optimal ROC cutoff for cTnT to predict the composite of MACE was 2.69 microg/l measured on day 4 and 2.85 microg/l for the cTnT peak. CONCLUSIONS: A single measurement of cTnT after STEMI is an independent predictor for MACE, performs as effective as serial cTnT sampling and may be useful to assess future events.


Assuntos
Infarto do Miocárdio/diagnóstico , Troponina T/sangue , Área Sob a Curva , Biomarcadores/sangue , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Miocárdio/metabolismo , Valor Preditivo dos Testes , Prognóstico , Curva ROC , Análise de Regressão , Taxa de Sobrevida , Fatores de Tempo
12.
J Am Coll Cardiol ; 51(3): 307-14, 2008 Jan 22.
Artigo em Inglês | MEDLINE | ID: mdl-18206741

RESUMO

OBJECTIVES: We compared single-point cardiac troponin T (cTnT) measurements with parameters from serial sampling during 96 h after acute myocardial infarction with magnetic resonance imaging measured infarct mass. BACKGROUND: Contrast-enhanced magnetic resonance imaging (CE-MRI) allows exact quantification of myocardial infarct size. Clinically, measurement of cardiac biomarkers is a more convenient alternative. METHODS: The CE-MRI infarct mass was determined 4 days after primary percutaneous coronary intervention in 31 ST-segment elevation myocardial infarction (STEMI) and 30 non-ST-segment elevation myocardial infarction (NSTEMI) patients. All single-point, peak, and integrated area under the curve (AUC) cTnT values were plotted against CE-MRI infarct mass. RESULTS: All single-point and serial cTnT values were significantly higher in STEMI than in NSTEMI (p < 0.01) patients. Except for the admission values, all single-point values on any of the first 4 days, peak cTnT and AUC cTnT were found to correlate comparably well with infarct mass. Among single-point measurements, cTnT on day 4 (cTnTD4) showed highest correlation and performed as well as peak cTnT or AUC cTnT (r = 0.66 vs. r = 0.65 vs. r = 0.69). Receiver-operator characteristic analysis demonstrated that cTnTD4 >0.84 microg/l predicted infarct mass above median as well as peak cTnT >1.57 microg/l or AUC cTnT (receiver-operator characteristic for AUC: 0.839 vs. 0.866 vs. 0.893). However, estimation of infarct mass with cTnTD4, peak cTnT, and AUC cTnT was worse in patients with NSTEMI (r = 0.36, r = 0.5, r = 0.36) than in STEMI (r = 0.75 vs. r = 0.65 vs. r = 0.76). CONCLUSIONS: All single-point cTnTs, except on admission, give a good estimation of infarct size and perform as well as peak cTnT or AUC cTnT. Infarct estimation by single-point measurements, particularly cTnTD4, may gain clinical acceptance because the measurement is easy and inexpensive.


Assuntos
Imageamento por Ressonância Magnética , Infarto do Miocárdio/patologia , Miocárdio/patologia , Troponina T/sangue , Idoso , Biomarcadores/sangue , Angiografia Coronária , Eletrocardiografia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Infarto do Miocárdio/sangue , Infarto do Miocárdio/diagnóstico , Curva ROC , Estatísticas não Paramétricas , Função Ventricular Esquerda
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