1.
Nat Chem Biol
; 6(3): 199-201, 2010 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20098427
RESUMO
Herein we describe the synthesis of highly substituted chromans and isochromans using carbohydrates as starting materials. Our approach makes use of a Pd-catalyzed domino reaction consisting of oxidative addition, followed by two carbopalladation steps and completed by a cyclization to annelate the benzene moiety. The versatility of this route has been demonstrated by a small library of highly substituted chromans and isochromans.