[Fulminant course of a Takayasu's arteritis and rare mesenteric arterial maninfestion]. / Fulminanter Verlauf einer Takayasu-Arteriitis und seltener mesenterialer Gefässbefall.

Takayasu's arteritis is a systemic disease, presenting as chronic inflammation of the main arteries. It usually affects the aorta and its large branches. General symptoms often include fatigue, subfebrile temperatures and weight loss. Complaints due to perfusion disorders are, for example, muscle pain, dizziness or claudication. Takayasu's arteritis is a rare disease which generally occurs in female patients under 40 years of age. We report on a patient with primary involvement of the mesenteric arteries. The disease process was fulminant and refractory to all therapeutic strategies. According to our knowledge this is the first case report from Germany of Takayasu's arteritis with mesenteric infarction.

[Cytofotometrically Determined DNA-pattern of premalignant cases of dysplasia of the cervix uteri. Contribution to the problem of morphologic definition and clinical sigificance of these lesions (author's transl)]. / Zytofotometrisch ermittelte DNS-Muster in präkanzerösen Dysplasien der Cervix uteri. Beitrag zur morphologischen Abgrenzung und klinischen Wertigkeit dieser Plattenepithelveränderungen

24 cases of probably benign and precancerous epithelial lesions of the cervix uteri were analysed cytofotometrically. The specimens were stained after the method of Feulgen. Benign epithelial changes for instance metaplasia, regenerating epithelium, atrophic and parakeratotic epithelium, basal cell hyperplasia and cervix epithelium irritated by inflammation, had normal diploid DNA-pattern. On the contrary premalignant dysplasia of all stages show an aneuploid DNA-content in every case. The cases of dysplasia had no diploid mode, an atypical proliferation with polyploidisation of an atypical way, DNA-stemlines and a broad scattering of DNA-values. Carcinoma in situ had a similar DNA-content. These data confirm the hypothesis premalignant dyplasia is a reality between normal cervical epithelium and carcinoma in situ. For now only severe grades of dysplasia have been treated by operation (i. e. conisation, hystectomy) not the low grade cases of dysplasia. With regard to DNA-histograms of dysplasia of all grades this seems to be unjustified.