RESUMO
A method is reported which permits an assessment of the effect of radiation, especially with 198Au, upon primary cultures. Thus, a statement of the individual radiation sensitivity of a tumor can be made, which is not possible with conventional methods. The tumors investigated by us exhibited a dependence of their cells in vitro upon the activity of the radiogold, and different tumors revealed a different radiosensitivity to the same dose.
Assuntos
Neoplasias dos Genitais Femininos/radioterapia , Radioisótopos de Ouro/uso terapêutico , Células Cultivadas , Feminino , Humanos , Neoplasias Ovarianas/patologia , Neoplasias Ovarianas/radioterapia , Tolerância a Radiação , Neoplasias Uterinas/patologia , Neoplasias Uterinas/radioterapiaRESUMO
The authors observed the effect of colloidal 198Au on the morphology of cells in 19 cell cultures of human tumors. Partly, there were typical modifications. The reactions of the individual cells were different and the radiosensibility and dependence on the dose seemed to vary with different concentrations of the radiogold. The importance of this study with regard to clinical problems is discussed.