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Humangenetik ; 27(1): 45-8, 1975.
Artigo em Inglês | MEDLINE | ID: mdl-124700

RESUMO

HL-A antigen frequencies were examined in 76 Down's syndrome individuals and 733 normal Caucasians. 10 antigens of the first locus and 15 antigens of the second locus were defined, using a microlymphocytotoxicity technique. No significant differences were observed between the normal and Down's syndrome samples, in contrast to a previous report (Boxer and Yokoyama, 1972) of decreased HL-A antigen frequencies in Down's syndrome individuals. Our results therefore suggest that there is no relationship between trisomy 21-associated immune aberrations and altered HL-A antigen frequencies.


Assuntos
Síndrome de Down/imunologia , Frequência do Gene , Antígenos HLA , Antígenos de Histocompatibilidade , Adolescente , Adulto , Alelos , Criança , Testes Imunológicos de Citotoxicidade , Humanos , Pessoa de Meia-Idade
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