RESUMO
Osteomyelitis secondary to Streptococcus pneumoniae in any location is rare. We present herein a patient with pneumococcal vertebral body osteomyelitis following prior trauma to the same region. Trauma is an important predisposing factor in the pathogenesis of vertebral osteomyelitis.
Assuntos
Osteomielite/etiologia , Infecções Pneumocócicas/etiologia , Doenças da Coluna Vertebral/etiologia , Vértebras Torácicas/lesões , Humanos , Masculino , Pessoa de Meia-Idade , Osteomielite/microbiologia , Osteomielite/fisiopatologia , Infecções Pneumocócicas/microbiologia , Infecções Pneumocócicas/fisiopatologia , Doenças da Coluna Vertebral/microbiologia , Doenças da Coluna Vertebral/fisiopatologia , Streptococcus pneumoniae/isolamento & purificaçãoRESUMO
The isolation and characterization of type III collagen from adult human lung parenchyma are described. The identity of this molecule as type III collagen has been established on the basis of (a) demonstration of intramolecular disulfide cross-links in the helical portion of the molecule, (b) amino acid analysis characteristic for type III collagen, and (c) composition and size of isolated cyanogen bromide peptides alpha1(III)-CB3, alpha1(III)-CB5, and alpha1(III)-CB8. The molecular weight of lung alpha1(III) was determined as 93 000 by Agarose chromatography, but its electrophoretic mobility on sodium dodecyl sulfate-polyacrylamide gels was slower than that of type I alpha chains which also have a molecular weight of 93 000.
