Isoprinosine increases the antitumor action of interferon.

The association of relatively low doses of interferon with an immunostimulant, isoprinosine, enhanced the antitumor effect of interferon. Each mouse was inoculated with 10(6) Crocker Tumor 180/TG cells. The best results were obtained when both interferon and isoprinosine were injected three times a week for 1 month. Under these conditions, the mean survival time increased from 26 days in the controls to 45 days in the interferon-treated group to 64 days when both agents were used. Isoprinosine alone had no effect. The final survival rate increased from 1 mouse out of 50 mice in the control group to 10 mice out of 50 in the interferon-treated groups and to 25 mice out of 50 with the combined treatment.

Isoprinosine increases the antitumor action of interferon.

The association of relatively low doses of interferon with an immunostimulant (isoprinosine) enhances the antitumor effect of interferon. After combined treatment, the mean survival time, tumor incidence, and final survival rate are significantly increased in mice inoculated with 10(6) Crocker tumor 180/TG cells when compared to mice treated with interferon alone.

[Mathematical simulation model of cardiac contraction]. / Modèle mathématique de simulation de la contraction cardiaque.

The authors describe a mathematical model simulating cardiac contraction based onMaxwell's well known analogue model. The general equations of the model are presented and discussed in relation to published findings. The functioning and compute application of the model are briefly described. The investigations were carried out in normal subjects and in some cases with simulated pathology. The first results obtained with the model and their relation to some biological phenomena (hemodynamics, ATP phasic activity, cardiac contractility) are discussed. The hypotheses on which the model is based are also discussed.