RESUMO
OBJECTIVES: To discuss the scientific rationale for the use of monoclonal antibodies in cancer treatment and distinguish the unique characteristics of selected monoclonal antibodies. DATA SOURCES: Published scientific papers, abstracts, review articles, and book chapters. CONCLUSION: The continued discovery of intrinsic antigens/epitopes specific to malignant cells and the science of immune cell activation demonstrates the durability of monoclonal antibodies as mainstream immunotherapy. IMPLICATIONS FOR NURSING PRACTICE: With the success of monoclonal antibodies used in clinical practice, oncology nurses need to continue to increase their knowledge and competency. Monoclonal antibodies target tumor-associated antigens in both solid and hematologic tumors. It is imperative that nurses be familiar with specific aspects of each antibody infusion they administer.
