The determination of pharmacokinetic parameters of ketotifen in steady state in young children.

Ketotifen kinetics at steady state in small children compared to adults show very good absorption for a dose of 2 X daily 1 mg. Relative to adult kinetics, a higher dose in relation to body weight is justified, since a more rapid kinetic pattern was proven for the substance in the volunteer collective tested.

[Cardiomyopathy in Duchenne muscular dystrophy. Part 2: serum enzymes, vector-cardiography, and echo-cardiography in 143 patients (author's transl)]. / Kardiomyopathie bei Duchennescher Muskeldystrophie.

To diagnose a possible latent or manifested cardiomyopathy, 143 male patients between 2 and 21 years of age with confirmed Duchenne muscular dystrophy were examined for serum enzymes, by electrocardiography, vector-cardiography, and echo-cardiography. The results contain information on 1. the quantitative cellular myocardial degeneration process, 2. the disturbed cellular depolarization and nerve-conduction processes in the area of the right and left ventricular myocard, and 3. the disturbed left ventricular function which, in the initial state, is only documented by a discrete decrease of contractility caused by a manifested decreased ejection output. The pathological contraction and relaxation process of the heart muscle cell and its dependency on calcium ion transport as pathogenic background is discussed.