[Results of modified ultra-high streptokinase lysis in patients with arterial occlusive disease. Preliminary report]. / Ergebnisse einer modifizierten UHSK bei Patienten mit AVK. Vorläufige Mitteilung.

The results of a modified UHSK lysis in patients with PAOD are presented. UHSK was most successful in the treatment of stenoses of the abdominal aorta and iliac stenoses/occlusions. After occlusions of bypasses and after angioplasty UHSK was less successful. The results after 4 and 6 hours of UHSK treatment were almost the same.

Catheter-lysis: indications and primary results.

Catheter-lysis--local low-dose fibrinolytic therapy--extends the indication to catheter-treatment. Occlusions longer than 10 cm younger than 3 months may be treated by this method. This treatment is primarily indicated for Fontaine stage III/IV occlusions. The complication of acute embolism or acute reocclusion during routine angioplasty can be treated satisfactorily by catheter-lysis. The primary result of low-dose fibrinolysis depends on the clinical stage, peripheral outflow, age and length of the occlusion.

Repeated percutaneous transluminal catheter-treatment. Primary results.

An advantage of angioplasty lies in the repeatability of this method in the same vascular section, if reobliteration or restenosis occur. In 154 patients second PTA was performed in 159 extremities, in 26 third and in 4 fourth PTA. The best results of repeated PTA were observed in stenoses, as well in the iliac region as in the femoro-popliteal section. Because a reocclusion has unfavorable chances for a renewed PTA it is advisable to watch the patients. As soon as the patient suffers of more claudication, a new angiography is to be performed. The results of repeated PTA in state IV are worse than in state II, third PTA had only pour chances. Therefore a repeated PTA more than twice especially in obliterations is hardly justifiable.

[Intravenous fibrinolytic treatment in chronic ischemic heart disease (author's transl)]. / Intravenöse Fibrinolysetherapie bei chronischer koronarer Herzkrankheit.

In 13 male patients (mean age 49.1 years) with chronic ischemic coronary heart disease (7 transmural and 2 intramural myocardial infarctions), angina pectoris and signs of ischemia during exercise an intravenous streptokinase therapy was performed. The treatment was installed 18.9 months after infarction or after onset of angina pectoris. Before and after intravenous streptokinase therapy the following parameters were measured: history, heart volume, exercise-ECG, Swan-Ganz pulmonary artery measurements during exercise, aortic and left ventricular pressures, coronary angiography, left ventricular angiography. 1. Angina pectoris disappeared in 1 and became better in 4 patients. In none of the patients angina pectoris became worse. 2. The parameters for ischemia were not changed overall by the therapy. But in single patients signs of exercise-induced ischemia were influenced. 3. Mean values of left ventricular function (EF, LVEDP) were not changed. 4. Angiographic changes were discrete. 5. Complications of therapy and worsening of subjective parameters did not occur. 6. The angina pectoris behaviour in 5 patients (became better) is explained by changes of blood properties. The not-appearance of coronary artery occlusions is explained by the inhibition of platelet aggregation. 7. It is suggested that the effect of intravenous streptokinase therapy should be examined in patients with short-lasting angina pectoris and subgroups, such as initial angina pectoris.