Outcomes of the First 54 Pediatric Patients on Long-Term Home Parenteral Nutrition from a Single Brazilian Center.

OBJECTIVES: Data on multidisciplinary programs dedicated to home parenteral nutrition (HPN) in Latin America are limited. This study describes the results of the first multidisciplinary pediatric intestinal rehabilitation program for HPN at a public tertiary hospital in Brazil. METHODS: We retrospectively reviewed patients aged 0-18 years with intestinal failure (IF) who required parenteral nutrition (PN) for >60 days between January/2014 and December/2020. RESULTS: Fifty-four patients were discharged on HPN (15 achieved enteral autonomy, 34 continued on HPN at the end of the study, 1 underwent intestinal transplantation, and 4 died). The median (IQR) age at the study endpoint of patients who achieved enteral autonomy was 14.1 (9.7-19) versus 34.7 (20.4-53.9) months in those who did not achieve enteral autonomy. Overall prevalence of catheter-related thrombosis was 66.7% and catheter-related bloodstream infection rate was 0.39/1000 catheter-days. Intestinal failure-associated liver disease (IFALD) was present in 24% of all patients; none of the patients who achieved enteral autonomy had IFALD. All patients showed significant improvement in anthropometric parameters during the HPN period. The sociodemographic characteristics of the patients' family members were mothers less than 20 years old (7.5%), schooling time more than 10 years (55.5%), and household income between 1 and 3 times the minimum wage (64.8%). The 5-year survival rate for HPN is 90%, and 27.7% of patients achieve enteral autonomy. CONCLUSION: The treatment of pediatric patients with IF followed by a multidisciplinary pediatric intestinal rehabilitation program with HPN is feasible and safe in the Brazilian public health system.

The impact of breast reduction surgery on breastfeeding performance.

The impact of reduction mammoplasty surgery on breastfeeding performance was measured comparing a group of 49 Brazilian women who had undergone breast reduction surgery using transposition techniques with 96 controls. As determined by survival analysis, the women who underwent reduction mammoplasty had a significantly shorter time of breastfeeding duration. The prevalence of exclusive breastfeeding at 1 and 4 months was 21% and 4%, respectively, for women with surgery, and 70% and 22%, respectively, for controls (P < .001). The prevalence of any breastfeeding at 1, 6, and 12 months was 58%, 16%, and 10% for women with mammoplasty, and 94%, 58%, and 42% for controls (P < .001). For women with surgery, the median duration of exclusive and any breastfeeding was 5 days and 2 months, respectively, and 3 months and 6 months for controls. The results of this study suggest that breast reduction surgery may have a negative impact on breastfeeding performance.