1.
Antimicrob Agents Chemother
; 49(6): 2558-60, 2005 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15917573
RESUMO
Target-specific hypersusceptible strains of Saccharomyces cerevisiae were used to screen antifungal compounds. Two novel Erg7p inhibitors were identified, providing proof of principle of the approach taken. However, observed hypersensitivities to antifungals acting via other targets imply that use of this tool to identify the mode of action requires significant deconvolution.