1.
Immunol Cell Biol
; 101(8): 684-686, 2023 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37226854
RESUMO
In a recent article, Sen Santara et al. demonstrated that the activating natural killer (NK) cell receptor NKp46 binds to externalized calreticulin (ecto-CRT), leading to NK cell degranulation and target cell killing. They show that endoplasmic reticulum stress-induced ecto-CRT serves as a danger-associated molecular pattern, helping NK cells identify and eliminate infected, malignant, stressed or senescent cells.