RESUMO
To encourage transborder cooperation in breast cancer care in Europe, we explored possibilities with the German-Dutch border area as an example. Evidence-based breast cancer guidelines were searched and compared on the: (1) methodological quality (with AGREE (Appraisal of Guidelines for Research and Evaluation)), (2) content of recommendations and (3) evidence use. The methodological quality of the German (n=2) and Dutch guidelines (n=2) was generally sufficient and comparable, although the applicability and the editorial independence were not clearly documented in the Dutch guidelines. Regarding the content analysis, German recommendations were taken as a reference point, because of the highest AGREE scores. Twenty-one of 25 recommendations discussed in both guidelines were corresponding and 4 were different, 32 were not mentioned in the Dutch guideline. The guidelines shared little evidence (< or =11%). We conclude that there are possibilities to encourage transborder cooperation. The clinical context of our results should be examined by measuring the actual care in both countries preferably with quality indicators.
Assuntos
Neoplasias da Mama/terapia , Medicina Baseada em Evidências/normas , Guias de Prática Clínica como Assunto/normas , Estudos de Avaliação como Assunto , Feminino , Alemanha , Humanos , Cooperação Internacional , Oncologia/normas , Países Baixos , Garantia da Qualidade dos Cuidados de Saúde/normasRESUMO
Tests on human and animal cadavers were carried out to investigate the early postmortem decay of the lymphocyte membrane HLA-typing of cool-kept human cadavers can be performed within the first 36 h after death. Hereby, a possibility is obtained to determine HLA-ABC antigens of the deceased for hemogenetic or cornea transplantation purposes. The data obtained from animal experiments give evidence that the decay of the lymphocyte membrane follows a function of the Verhult's type. Using this function, it is possible to estimate the rate constant as a function of temperature.
