RESUMO
1. Prostaglandins E(1) and E(2) contracted the longitudinal muscle of human, guinea-pig and rat isolated ileum.2. The site of action varied with the species. In the rat and in some strips of human tissue prostaglandin appeared to have only a direct action on or in the muscle cells. In the other strips of human tissue and in guinea-pig ileum the prostaglandins seemed to stimulate both the intrinsic cholinergic nerves and the muscle cells.3. In contrast to the longitudinal muscle, the circular muscle of human, guinea-pig and rat isolated ileum was usually inhibited by prostaglandin, apparently by an action directly on the muscle cells.4. Prostaglandins may play a part in the control of intestinal motility.
Assuntos
Íleo/efeitos dos fármacos , Contração Muscular/efeitos dos fármacos , Prostaglandinas/farmacologia , Acetilcolina/farmacologia , Animais , Sítios de Ligação , Motilidade Gastrointestinal , Cobaias , Compostos de Hexametônio/farmacologia , Humanos , Ratos , Escopolamina/farmacologia , Especificidade da Espécie , Tetrodotoxina/farmacologiaRESUMO
1. Prostaglandins E(1) and E(2) affected intestinal activity both in vitro and in vivo.2. Serosal application of prostaglandin to guinea-pig isolated ileum stimulated the longitudinal muscle but reduced peristaltic contractions of the circular muscle and the propulsion of fluid through the gut. Intraluminal application had little effect.3. Injection of prostaglandin into the bloodstream of anaesthetized rats stimulated the longitudinal muscle of the ileum and increased the intraluminal pressure. A similar response sometimes occurred in the guinea-pig, but in general the effect was variable.4. Release of prostaglandin in the gut wall, but probably not into the blood or into the lumen of the gut, may play a part in controlling intestinal motility.
