Prospective effects of social support on self-actualization at work - The mediating role of basic psychological need fulfillment.

Self-actualization - an ethically meaningful, eudaimonic way of living - is achieved by self-determined activities and realizing one's highest potential. Therefore, personal growth and human fulfillment are considered central aspects. In accordance with self-determination theory this study aims to longitudinally investigate the mediating role of basic psychological need satisfaction - combined and separately - within the association between social support and indicators of self-actualization at work. 264 employees working in diverse economic sectors and occupations participated in the survey two times with a time lag of two months. Consistent with hypotheses the fulfillment of basic psychological needs in general as well as separately mediated the link between social support from different sources and self-actualization at work with one exception: Within the association between support from co-workers and indicators of self-actualization at work the need for relatedness did not have a significant mediating effect. Implications for future research and practice of promoting social support for personal development at the workplace are discussed.

Fungalysin and dipeptidyl-peptidase gene transcription in Microsporum canis strains isolated from symptomatic and asymptomatic cats.

Microsporum canis is the main pathogenic fungus that causes a superficial cutaneous infection called dermatophytosis in domestic carnivores. In cats, M. canis causes symptomatic or asymptomatic infection. Recent conflicting data raise the question of whether the clinical status of the infected cat (symptomatic or asymptomatic) is directly correlated to the proteolytic activity of M. canis strains. Here, the transcription of fungalysin and dipeptidyl-peptidase genes (DPP) of M. canis was compared between four strains isolated from symptomatic and asymptomatic cats during the first steps of the infection process, namely in arthroconidia, during adherence of arthroconidia to corneocytes and during early invasion of the epidermis, using a new ex vivo model made of feline epidermis. There was no detectable transcription of the fungalysin genes in arthroconidia or during the first steps of the infection process for any of the tested strains, suggesting that these proteases play a role later in the infection process. Among DPP, the DPP IV gene was the most frequently transcribed both in arthroconidia and later during infection (adherence and invasion), but no significant differences were observed between M. canis strains isolated from symptomatic and asymptomatic cats. This study shows that the clinical aspect of M. canis feline dermatophytosis depends upon factors relating to the host rather than to the proteolytic activity of the infective fungal strain.