PROMIS pain intensity and interference after pelvic organ prolapse surgery.

INTRODUCTION AND HYPOTHESIS: Patient-Reported Outcome Measurement Information System (PROMIS) questionnaires provide valid comparisons across disciplines. Pain measures can be used to track functional outcomes. Limited PROMIS pain data exist in gynecological surgery. We sought to use pain intensity and pain interference short forms to assess pain and recovery after pelvic organ prolapse surgery. METHODS: The PROMIS pain intensity and pain interference questionnaires were given to patients undergoing uterosacral ligament suspension (USLS), sacrospinous ligament fixation (SSLF) or minimally invasive sacrocolpopexy (MISC) at baseline, 1 week, and 6 weeks postoperatively. Clinical minimally important change was defined as a difference of 2-6 T-score points. Mean pain intensity and pain interference T-scores were compared at baseline, 1 week and 6 weeks with ANOVA. Multiple linear regression assessed 1-week scores adjusted for apical suspension type, advanced prolapse, concurrent hysterectomy, concurrent anterior or posterior repair, and concurrent sling. RESULTS: At 1 week, all apical suspension groups showed minimally important change in pain intensity and pain interference T-scores. Between groups at 1 week, pain interference was higher in USLS (66.3±6.6) and MISC (65.5±5.9) than in SSLF (59.2±9.8), p=0.01. Multiple linear regression showed an association of hysterectomy with increases in pain intensity and pain interference. USLS had a higher proportion of concurrent hysterectomy (100%) than SSLF (0%) and MISC (30.8%), p<0.01. No difference was found based on apical suspension type alone. CONCLUSIONS: No differences were found in PROMIS pain intensity and pain at 1 week postoperatively after apical suspension procedures.

De-Prescribing Inhaled Corticosteroids in Chronic Obstructive Pulmonary Disease: A Narrative Review.

Objective: Combination therapy, including inhaled corticosteroids (ICS), is often prescribed as initial treatment for Chronic Obstructive Pulmonary Disease (COPD) despite limited evidence that ICS therapy is beneficial. Prescribing rates exceed the estimated number of candidates diagnosed with COPD who are eligible for ICS treatment per guideline-directed therapy. Therefore, some patients would benefit from ICS withdrawal due to potentially inappropriate prescribing. This review aims to highlight evidence evaluating ICS withdrawal approaches in COPD. Methods: A comprehensive literature review was performed between June 2021 and March 2022 with assistance from a reference librarian. Sources of literature review include PubMed and Embase. The authors selected randomized controlled trials and articles evaluating ICS withdrawal approaches in patients with COPD. Three clinical trials and one post-hoc analysis are discussed in this review. Pertinent safety, efficacy, and statistical and clinical outcomes are summarized. Conclusions: The most appropriate approach to de-prescribe ICS maintenance therapy in COPD without clear indication remains uncertain. Pharmacists can play a role in optimizing clinical outcomes by analyzing ICS use in practice and identifying potential candidates for ICS withdrawal. The withdrawal protocols discussed in this review offer options for clinicians to help guide therapy decisions.

Accuracy of Visual Assessment of Urimeter Bag Volumes: The Whiz Quiz.

IMPORTANCE: Although visual estimate of urine output via urimeter bag is common, data on accuracy are limited. OBJECTIVE: This study aimed to assess the accuracy of a visual estimate of urine output in standard urimeter bags by health care workers. STUDY DESIGN: This is a prospective observational study. Perioperative health care workers were asked to visually estimate fluid volumes in 5 standard urimeter bags. Actual volumes were 50, 150, 350, 500, and 750 mL. Visual estimates were recorded. The primary outcome was accuracy, defined as estimated visual volume within 20% of actual volume. Secondary outcomes included effect of health care provider type, specialty, experience, sex, and age on accuracy. RESULTS: A total of 159 responses were analyzed. There were 55 (35.3%) registered nurses, 19 (12.2%) certified registered nurse anesthetists, 18 (11.5%) advanced practice providers not identified as a certified registered nurse anesthetist, and 64 (41%) physicians. Mean estimated volumes (in milliliters) ± standard deviation and accuracy for the bags were as follows: (a) actual volume of 50 mL and estimated volume of 66 ± 29 mL (45% accuracy), (b) actual volume of 150 mL and estimated volume of 149 ± 43 mL (46% accuracy), (c) actual volume of 350 mL and estimated volume of 356 ± 74 mL (76% accuracy), (d) actual volume of 500 mL and estimated volume of 452 ± 77 mL (85% accuracy), and (e) actual volume of 750 mL and estimated volume of 675 ± 108 mL (85% accuracy). There was reasonable accuracy for individual volume estimates, but accuracy across all 5 urimeter bags was low: 22 of 159 (13.8%). There were no significant differences in accuracy based on health care provider type, specialty, experience, sex, or age. CONCLUSIONS: Consistent accuracy of visual assessment of calibrated urimeter bag volumes was low and not influenced by health care provider characteristics.

Are Formal Voiding Trials Necessary After Posterior Compartment Reconstructive Surgery?

IMPORTANCE: Posterior compartment surgery is considered a risk factor for postoperative urinary retention because of the impact of postoperative pain on the pelvic floor; however, few studies have examined the association between posterior compartment reconstructive surgery and urinary retention. OBJECTIVE: The aim of the study was to compare rates of urinary retention in patients undergoing vaginal reconstructive surgery, without hysterectomy, in the posterior compartment only versus any apical and/or anterior compartment (with or without posterior compartment). STUDY DESIGN: In this retrospective cohort study, we evaluated patients who underwent surgery, without hysterectomy, in the posterior compartment only versus any apical and/or anterior compartment (with or without posterior compartment) from January 2015 to November 2020. Our primary outcome was rate of postoperative urinary retention, defined as a failed voiding trial before discharge. Secondary outcome was days of catheterization. Multivariable logistic regression was performed to assess variables associated with a failed voiding trial. RESULTS: Of 362 patients, 141 (39.0%) underwent surgery in the posterior compartment only and 221 (61.0%) underwent vaginal apical and/or anterior compartment surgical procedures. Rate of retention was significantly lower in the posterior compartment only group (9.9% vs 41.6%, P < 0.001). The median numbers of days of catheterization were significantly fewer in the posterior compartment only group (0 [0,0] vs 0 [0,3], P < 0.001). In multivariable logistic regression, posterior compartment only surgery was associated with passing the voiding trial (odds ratio, 6.0; 95% confidence interval, 2.97-12.03). CONCLUSIONS: Rates of postoperative urinary retention after surgery in the posterior compartment are low, and these patients may not require formal voiding trials after surgery.

Route of Hysterectomy at the Time of Sacrocolpopexy: A Multicenter Retrospective Cohort Study.

OBJECTIVES: This study aimed to compare the incidence of mesh exposure based on route of hysterectomy at the time of minimally invasive sacrocolpopexy. Secondary outcomes included perioperative outcomes and prolapse recurrence. METHODS: This was a multicenter, retrospective cohort study. Patients who underwent sacrocolpopexy between 2007 and 2017 were stratified by hysterectomy approach: total vaginal hysterectomy (TVH), total laparoscopic or robotic hysterectomy (TLH), and laparoscopic or robotic supracervical hysterectomy (LSH). Total vaginal hysterectomy was subdivided into vaginal and laparoscopic mesh attachment to the cuff. Statistical analyses were performed, with P < 0.05 denoting statistical significance. RESULTS: Seven institutions participated, and 502 minimally invasive sacrocolpopexies with concomitant hysterectomy were performed by 23 surgeons: 263 TVH, 128 TLH, and 111 LSH. The median follow-up interval was 10 months, and this was significantly different between the groups (months): TVH, 11 (3-13); TLH, 2 (2-9); and LSH, 12 (5-24; P < 0.01). The overall incidence of vaginal mesh exposure was 4.0% (20/502). There were no significant differences in vaginal mesh exposure based on hysterectomy route: TVH, 5.7% (15/263); TLH, 1.6% (2/128); and LSH, 2.7% (3/111; P = 0.11). Within the TVH group, there was no significant difference in vaginal mesh exposure comparing vaginal and laparoscopic mesh attachment: 1.9% (1/52) versus 6.6% (14/211; P = 0.48). Laparoscopic supracervical hysterectomy demonstrated a significantly higher incidence of recurrence compared with TVH and TLH: 10.8% (12/111) versus 3.4% (9/263) and 2.3% (3/128; P < 0.01). CONCLUSIONS: The incidence of sacrocolpopexy mesh exposure was not significantly different based on route of hysterectomy or mode of mesh attachment to the vagina. There was a significant increase in prolapse recurrence with supracervical hysterectomy.

Evaluation of a Rubric to Assess Pharmacy Student Performance in a Telehealth Simulation Exercise.

Objective. To evaluate a telehealth simulation rubric for a pharmacy skills lab course using interrater reliability (IRR) to compare different evaluator types.Methods. A rubric was developed and used to score student pharmacists' competency in a telehealth simulation for a pharmacy skills lab course. Intraclass correlation coefficients (ICCs) were calculated to determine the IRR.Results. Fifty-five recorded telehealth simulation sessions were scored three times by a pool of evaluators using the rubric. The overall ICC for the rubric was 0.631 across different types of evaluators, indicating good IRR. Differences in ICCs were observed when they were calculated for type of evaluator and rubric subcomponents.Conclusion. The rubric demonstrated good IRR across multiple types of evaluators when used in a skills lab course. Additional evaluation of the rubric and continuous quality improvement is warranted to ensure that assessment becomes more consistent with continued use, regardless of the evaluator type.

Validation Evidence using Generalizability Theory for an Objective Structured Clinical Examination.

OBJECTIVES: Performance-based assessments, including objective structured clinical examinations (OSCEs), are essential learning assessments within pharmacy education. Because important educational decisions can follow from performance-based assessment results, pharmacy colleges/schools should demonstrate acceptable rigor in validation of their learning assessments. Though G-Theory has rarely been reported in pharmacy education, it would behoove pharmacy educators to, using G-Theory, produce evidence demonstrating reliability as a part of their OSCE validation process. This investigation demonstrates the use of G-Theory to describes reliability for an OSCE, as well as to show methods for enhancement of the OSCE's reliability. INNOVATION: To evaluate practice-readiness in the semester before final-year rotations, third-year PharmD students took an OSCE. This OSCE included 14 stations over three weeks. Each week had four or five stations; one or two stations were scored by faculty-raters while three stations required students' written responses. All stations were scored 1-4. For G-Theory analyses, we used G_Strings and then mGENOVA. CRITICAL ANALYSIS: Ninety-seven students completed the OSCE; stations were scored independently. First, univariate G-Theory design of students crossed with stations nested in weeks (p × s:w) was used. The total-score g-coefficient (reliability) for this OSCE was 0.72. Variance components for test parameters were identified. Of note, students accounted for only some OSCE score variation. Second, a multivariate G-Theory design of students crossed with stations (p• × s°) was used. This further analysis revealed which week(s) were weakest for the reliability of test-scores from this learning assessment. Moreover, decision-studies showed how reliability could change depending on the number of stations each week. For a g-coefficient >0.80, seven stations per week were needed. Additionally, targets for improvements were identified. IMPLICATIONS: In test validation, evidence of reliability is vital for the inference of generalization; G-Theory provided this for our OSCE. Results indicated that the reliability of scores was mediocre and could be improved with more stations. Revision of problematic stations could help reliability as well. Within this need for more stations, one practical insight was to administer those stations over multiple weeks/occasions (instead of all stations in one occasion).

Patient Satisfaction With Diabetes Care in a Student-Run Free Medical Clinic: A Quality Improvement Study.

Background: Diabetes prevalence continues to be a concern and the management of diabetes is important but costly. The prevalence of diabetes is greater among persons with a low income, including those who are uninsured or underinsured. Student-run free clinics (SRFC) are one resource to these patients who may otherwise lack access to medical care. Objective: The purpose of this study was to assess patient satisfaction with diabetes care at a SRFC in order to assist in identifying areas of improvement. Methods: A quality improvement survey was designed to assess patient satisfaction with overall care, as well as with routines and perception of care related to self-management, healthy eating, and exercise. Results: The survey was completed by 25 patients at a Toledo area SRFC. Established patients who were aged 18 years or older and diagnosed with diabetes, were invited to complete the survey. The majority of patients were satisfied with their diabetes care at the SRFC (88%). Fewer patients, however, reported satisfaction with the treatment for their diabetes (72%) and with their knowledge about diabetes (76%). Subanalyses of survey responses also showed significant differences when comparing sex, age, and length of diabetes diagnosis. Conclusions: The survey helped identify key areas in which the diabetes care provided at the SRFC could be improved. These areas included education about diabetes in general, as well as in understanding treatment, self-monitoring, and healthy eating and exercise options. Future research could explore survey results after specifying and implementing changes made to the education provided to the patients.

Impact of a Pharmacy-Initiated Inpatient Diabetes Patient Education Program on 30-Day Readmission Rates.

BACKGROUND: In October 2012, a pharmacy-driven Inpatient Diabetes Patient Education (IDPE) program was implemented at the University of Toledo Medical Center (UTMC). OBJECTIVE: To determine the difference in 30-day hospital readmission rates for patients who receive IDPE compared to those who do not. METHODS: This retrospective cohort was completed at UTMC. Patients admitted between October 1, 2012, and September 30, 2013, were included if they were ≥18 years and had one of the following: (1) diagnosis of diabetes mellitus, (2) blood glucose >200 mg/dL (>11.11 mmol/L) on admission, or (3) hemoglobin A1C of >6.5% (>48 mmol/mol). Patients who received IDPE from a pharmacist or student pharmacist (intervention group) were compared to patients who did not receive IDPE (control group). RESULTS: The 30-day readmission rate was 13.2% for the intervention group (n = 364) and 21.5% for the control group (n = 149) (P = .023). Average time to 30-day readmission was 13.1 (±8.3) days for the IDPE group and 11.9 (±7.9) days for the control group. There was no significant difference in diabetes-related readmission between the intervention and control groups (25.5% vs 21.9%). CONCLUSIONS: An IDPE program delivered primarily by pharmacists and student pharmacists significantly reduced 30-day readmission rates among patients with diabetes.

Implementation of a Cardiac Transitions of Care Pilot Program: A Prospective Study of Inpatient and Outpatient Clinical Pharmacy Services for Patients With Heart Failure Exacerbation or Acute Myocardial Infarction.

BACKGROUND:: Pharmacists may assist with reducing 30-day readmission rates for patients with heart failure (HF) exacerbation or acute myocardial infarction (AMI) by promoting medication adherence. OBJECTIVE:: To determine the change in 30-day readmission rates for patients with HF exacerbation or AMI after implementation of a "high-touch" standard of care. METHODS:: Patients admitted with HF exacerbation, non-ST-segment elevation AMI, or ST-segment elevation AMI from August 1, 2013, to June 30, 2015, were included in this prospective study. Patients were educated while in the inpatient setting and followed up in the outpatient setting through telephone contact and scheduling a medication therapy management (MTM) appointment with a pharmacist. Data were collected by pharmacy personnel involved in the implementation of the intervention. RESULTS:: Within the HF and AMI arms, 100 and 93 patients, respectively, were included in the study. The 30-day readmission rates were 24% and 17.2% for HF and AMI, respectively, which were not statistically significant when compared to historical institutional readmission rates prior to study initiation (18.2% for HF, P = .238; 11.4% for AMI, P = .252). CONCLUSION:: A "high-touch" pharmacist-driven transitions of care program may affect 30-day readmission rates for patients with HF exacerbation or AMI; potential processes for initiating transitions of care programs are provided.

Perspectives of athletes and pharmacists on pharmacist-provided sports supplement counseling: An exploratory study.

OBJECTIVES: To identify athletes' interests in receiving advice about sports supplements from a pharmacist in a supermarket setting and to identify pharmacists' knowledge, confidence, and enthusiasm for providing counseling on various sports supplements. METHODS: Two cross-sectional surveys were developed and administered. One survey was administered to athletes at local northwestern Ohio fitness facilities, and 1 survey was administered to pharmacists in chain pharmacies during mid-February to mid-March 2017. The athlete survey gathered demographic information, information sources, products purchased, including their location and selection factors, and perceptions of pharmacists providing sports supplement counseling. The pharmacist survey gathered demographic information; knowledge, confidence, and enthusiasm for providing sports supplement counseling; perceptions of counseling benefit; and barriers to implementation of providing a sports supplement counseling service. RESULTS: The athlete survey had 129 participants. Athletes primarily reported obtaining sports supplement information from supplement stores, and only 2% indicated using a pharmacist. Although 52% said they would talk to a pharmacist about sports supplements, 66% said their perception of a pharmacist's fitness level would influence whether or not they would approach him or her. The pharmacist survey had 143 participants. On a 5-point Likert-type scale (1 = strongly disagree and 5 = strongly agree), the mean (SD) of their knowledge, confidence, and enthusiasm statements were 2.49 (0.89); 2.61 (0.94); and 3.54 (0.87), respectively. Ninety-two percent (n = 130) of pharmacists thought it would be beneficial to provide counseling on sports supplements. Perceived barriers included lack of knowledge, evidence, and time. CONCLUSION: Pharmacists were not identified as a primary resource for sports supplements, but athletes would be willing to discuss this topic with knowledgeable and physically fit pharmacists. Pharmacists felt that they lacked knowledge and confidence regarding sports supplement products but noted enthusiasm to provide counseling. Sports pharmacy counseling could be a viable expansion of pharmacy services in community pharmacies with proper education and tools.

Community Pharmacy-Based Adherence Programs and the Role of Pharmacy Technicians: A Review.

Objective: To increase pharmacy technician awareness of medication nonadherence enabling them to identify opportunities to participate in the provision of community pharmacy-based adherence programs. Data Sources: Articles were identified through searches of MEDLINE/PubMed (1950 through December 2014) using the following search terms: "adherence," "role of technicians," "community adherence programs," "adherence and technician's role," "medication synchronization," "retail pharmacy adherence programs," and "CMS Star Ratings." Additionally, resources on adherence programs were used from the American Society of Health-System Pharmacists, the American Pharmacists Association, and the Food and Drug Administration. Study Selection and Data Extraction: Articles describing community pharmacy adherence programs, the role of pharmacy technicians in providing these services, and medication synchronization were included. Data Synthesis: Nonadherence to medications creates a burden in terms of patient health and leads to high health care costs to the patients, providers, and insurers. Initiatives on pharmacist-led adherence programs have proven to reduce these overall health care-related costs. Pharmacy technicians can have an active role in the management of these adherence programs to reduce the burden on community pharmacists who are running adherence programs. Pharmacy technicians can be responsible for gathering medication histories, organizing patient medication lists, making appointment calls to schedule patients, collecting patient demographic history, conducting follow-up calls, and in promoting the program overall. Conclusions: Pharmacy technicians are a valuable asset to the community pharmacists in the process of running adherence programs, and they can work with the pharmacists to coordinate and promote community pharmacy-based medication adherence programs.