A case report of the successful treatment of recurrent aphthous stomatitis with some preparations of orally administered transfer factor.

A patient with severe disabling recurrent aphthous stomatitis (RAS) was treated with four different preparations of oral human transfer factor (TF), as well as placebo, following a double-blind protocol. Two of the TF preparations had a significant effect upon the course of the patient's illness by prolonging the interval between attacks and decreasing the severity of attacks. No side effects attributable to any of the preparations were noted by the patient. Thus, some but not all preparations of human transfer factor given orally are an effective therapy for RAS.

Transfer factor as an approach to the treatment of immune deficiency disease.

Use of transfer factor in the treatment of chronic mucocutaneous candidiasis is discussed. The clinical experience in treating 2 patients with different clinical expressions of the syndrome and their different responses to treatment with repeated injections of transfer factor given in conjunction with amphotericin-B are reported. Results indicate that this form of therapy is a safe and effective way of restoring cell-mediated immunity to Candida and successfully treating some patients with chronic mucocutaneous candidiasis.

Specific secondary biological properties of purified rabbit immunoglobulin M and immunoglobulin G antibodies to Brucella abortus and Bordetella pertussis.

Rabbit immunoglobulin (Ig)M and IgG antibodies to Brucella abortus and Bordetella pertussis were isolated as purified products and their specific secondary biological activities were compared. IgM antibodies were found to be more active than IgG proteins in inducing agglutination and sensitization of B. abortus for the complement-dependent bactericidal effect and in inhibiting B. pertussis-induced lymphocytosis in the mouse. IgM and IgG antibodies were found to be equally effective in inducing agglutination of B. pertussis suspended in a colloidal solution. These data parallel previous work to indicate that IgM antibodies to bacterial surface antigens are more efficient than IgG molecules in initiating biological processes concerned with the inactivation of these pathogens.

Effect of Purified Rabbit Anti-Salmonella typhimurium Antibodies on the Fate of Intravenously Injected Bacteria.

Purified IgM and IgG antibodies to Salmonella typhimurium "O" antigen were prepared from rabbit serum collected "early" (6 to 8 days) and "late" (30 to 32 days) during the course of the immune response. The effect which these passively administered antibodies had upon the reticuloendothelial organ sequestration of intravenously injected (125)I-labeled heat-killed S. typhimurium in nonimmune rabbits was studied. In the absence of specific antibody, the spleen (per gram) sequestered more organisms than did the liver, kidneys, and lungs. In the presence of "early" antibody to S. typhimurium, sequestration of organisms in the spleen was two to three times greater than sequestration in the spleen of animals that had received "late" antibody to S. typhimurium, heterologous antibody or no antibody. Although "late" antibody did not increase sequestration of organisms in the spleen, it did result in a per gram liver sequestration of bacteria which was two times greater than that observed in animals that had received "early" antibodies to S. typhimurium, heterologous antibody or no antibody. The presence of passively administered antibody had no detectable effect upon the sequestration of bacteria in the kidneys and the lungs. Thus, it would seem that antibodies isolated early in the immune response increase the efficiency of splenic sequestration of blood-borne particulate material, whereas "late" antibody favors sequestration in the liver.