Heat-related cardiovascular morbidity and mortality in Switzerland: a clinical perspective.

AIMS: Previous studies found increased cardiovascular mortality during hot days, while emergency hospital admissions were decreasing. We explored potential underlying reasons by analysing clinically similar cardiovascular disease groups taking into account primary, underlying and immediate causes of death. METHODS AND RESULTS: We assessed associations of daytime maximum temperature in relation to cardiovascular deaths and emergency hospital admissions between 1998 and 2016 in Switzerland. We applied conditional quasi-Poisson models with non-linear distributed lag functions to estimate relative risks (RRs) of daily cardiovascular mortality and morbidity for temperature increases from the median (22°C) to the 98th percentile (32°C) of the warm season temperature distribution with 10 days of lag. Cardiovascular mortality (n = 163,856) increased for total cardiovascular disease (RR 1.13, 95% confidence interval [CI] 1.08-1.19) and the disease groups hypertension (1.18, 1.02-1.38), arrhythmia (1.29, 1.08-1.55), heart failure (1.22, 1.05-1.43) and stroke of unknown origin (1.20, 1.02-1.4). In contrast, emergency hospital admissions (n = 447,577) decreased for total cardiovascular disease (0.91, 0.88-0.94), hypertension (0.72, 0.64-0.81), heart failure (0.83, 0.76-0.9) and myocardial infarction (0.88, 0.82-0.95). Opposing heat effects were most pronounced for disease groups associated with diuretic and antihypertensive drug use, with the age group ≥75 years at highest risk. CONCLUSIONS: Volume depletion and vasodilation from heat stress plausibly explain the risk reduction of heat-related emergency hospital admissions for hypertension and heart failure. Since primary cause of death mostly refers to the underlying chronic disease, the seemingly paradoxical heat-related mortality increase can plausibly be explained by an exacerbation of heat effects by antihypertensive and diuretic drugs. Clinical guidelines should consider recommending strict therapy monitoring of such medication during heatwaves, particularly in the elderly.

Effect of legroom proportions and individual factors for sitting with crossed legs: implications on the interior design of automated driving vehicles.

Sitting with crossed legs is a commonly adopted sitting posture in everyday situations. Yet, little is known about suitable design criteria to facilitate such a position inside a vehicle. This study is aimed at determining how much space is necessary for crossing the legs while considering legroom restrictions, anthropometric measures, and individual flexibility. More specifically, 3 D-kinematics of an ankle-on-knee leg-crossing task and the easiness to move ratings of 30 participants were assessed with restrictions of the legroom (2 heights × 3 distances) as well as without restrictions. Functional regression models revealed adaptations to a legroom restriction in the execution of movement, which occurred mainly in the knee joint and increased with more restricted legroom proportions. Therefore, the present study suggests a distance of 120% of the buttock-knee length between the dashboard and the occupant, as it requires only moderate adaptations and does not affect the perceived easiness of move. Practitioner Summary: This research investigated how much space is needed to cross the legs while sitting in a vehicle, finding that the movement execution is affected by legroom proportions, as well as individual anthropometry and flexibility. The study further presents the use of predicted motion traces to determine spatial requirements of movements. Abbreviations: BKL: buttock-knee length; H-point: hip point.