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OBJECTIVES: Our study comprised a single-center retrospective in vitro correlation between spectral properties, namely ρ/Z values, derived from scanning blood samples using dual-energy computed tomography (DECT) with the corresponding laboratory hemoglobin/hematocrit (Hb/Hct) levels and assessed the potential in anemia-detection. METHODS: DECT of 813 patient blood samples from 465 women and 348 men was conducted using a standardized scan protocol. Electron density relative to water (ρ or rho), effective atomic number (Zeff), and CT attenuation (Hounsfield unit) were measured. RESULTS: Positive correlation with the Hb/Hct was shown for ρ (r-values 0.37-0.49) and attenuation (r-values 0.59-0.83) while no correlation was observed for Zeff (r-values -0.04 to 0.08). Significant differences in attenuation and ρ values were detected for blood samples with and without anemia in both genders (p value < 0.001) with area under the curve ranging from 0.7 to 0.95. Depending on the respective CT parameters, various cutoff values for CT-based anemia detection could be determined. CONCLUSION: In summary, our study investigated the correlation between DECT measurements and Hb/Hct levels, emphasizing novel aspects of ρ and Zeff values. Assuming that quantitative changes in the number of hemoglobin proteins might alter the mean Zeff values, the results of our study show that there is no measurable correlation on the atomic level using DECT. We established a positive in vitro correlation between Hb/Hct values and ρ. Nevertheless, attenuation emerged as the most strongly correlated parameter with identifiable cutoff values, highlighting its preference for CT-based anemia detection. CLINICAL RELEVANCE STATEMENT: By scanning multiple blood samples with dual-energy CT scans and comparing the measurements with standard laboratory blood tests, we were able to underscore the potential of CT-based anemia detection and its advantages in clinical practice. KEY POINTS: Prior in vivo studies have found a correlation between aortic blood pool and measured hemoglobin and hematocrit. Hemoglobin and hematocrit correlated with electron density relative to water and attenuation but not Zeff. Dual-energy CT has the potential for additional clinical benefits, such as CT-based anemia detection.
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Ultrastable high-power laser systems are essential components of the long baseline interferometers that detected the first gravitational waves from merging black holes and neutron stars. One way to further increase the sensitivity of current generation gravitational wave detectors (GWDs) is to increase the laser power injected into the interferometers. In this Letter, we describe and characterize a 72 W and a 114 W linearly polarized, single-frequency laser system at a wavelength of 1064 nm, each based on single-pass Nd:YVO4 power amplifiers. Both systems have low power and frequency noise and very high spatial purity with less than 10.7% and 2.9% higher order mode content, respectively. We demonstrate the simple integration of these amplifiers into the laser stabilization environment of operating GWDs and show stable low-noise operation of one of the amplifier systems in such an environment for more than 45 days.
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The generation of millijoule-level ultrashort laser pulses at a wavelength of 2.05 µm in a compact chirped pulse amplification-free linear amplifier based on Holmium-doped YLF gain medium is presented. More than 100 MW of pulse peak power has been achieved. We show the capabilities of this laser amplifier from a 1 kHz to 100 kHz repetition rate. A detailed numerical description supports the experimental work and verifies the achieved results.
RESUMO
An amplifier design for efficient amplification of linearly polarized fundamental mode lasers is presented. The concept was verified by amplifying single-frequency input powers from 1 W to 20 W into output power ranges of 35 W up to 65 W. Beam quality measurements with a mode-analyzer cavity showed only minor beam quality degradation due to the amplification process.
