A natural rubber drainage tube with antithrombogenic lumen surface.

A drainage tube was made by radiation vulcanization of a high polymeric substance based on natural rubber elastomers. Pentosan polysulphate sodium bound to a carrier substance (synthetic type 4A or 13X zeolite) was incorporated in the drainage tube which was then tested for its anticoagulant properties during perfusion with Tris buffer solution, citrated plasma, and blood, resp. The amount of pentosan polysulphate sodium released from the tube walls during perfusion with human citrated plasma in an open circulatory system was sufficient to exert an anticoagulant effect on the streaming plasma. This effect was corroborated by prolonged thrombin times and by unclottability in case of recalcified plasma samples in thrombelastographic studies. The antithrombogenicity test according to Chandler in a closed circulatory system revealed thrombus formation times (TFT) of more than 24 h (control: TFT = 1-3 min in native blood).

[Exposure to asbestos dust and asbestosis of employees in a Thüringen rubber industry]. / Zur Asbeststaubexposition und Asbestose der Werktätigen in einem Gummibetrieb Thüringens.

131 exposed people by dust of talc in rubber industry in Thuringia were examined by contrast to a same no examined group of working people. The asbestos in talc did cause in 26 (19.8%) cases of exposed people a pneumoconiosis. The occupational disease was admitted. The time of development was between 20 and 40 years. We can found the chronic bronchitis and demages of ventilation much more in cases long time exposed people and by smokers. The following conclusions are: the renunciation of application of talc with asbestos, measures to fight against dust, the instruction of direction and of working people about the danger of asbestos and the dispensatory care for life.

Molecular cloning, sequencing and expression in Escherichia coli of the 25-kDa growth-related protein of Ehrlich ascites tumor and its homology to mammalian stress proteins.

The growth-related 25-kDa protein (p25) of Ehrlich ascites tumor (EAT) has been characterized by molecular cloning and sequencing of cDNA clones detected by hybridization with oligonucleotide probes synthesized according to the amino acid sequence of a tryptic peptide of p25. Detection of p25 mRNA in EAT of the exponential growth phase and of the stationary phase using cDNA-derived RNA probes demonstrated that the abundance of p25 mRNA is also growth-related. High-level expression of p25 in Escherichia coli has been established by oligonucleotide-directed mutagenesis of cDNA and insertion of the mutated cDNA into a T7-promoter expression vector. Recombinant p25 from the expressed cDNA sequence has been shown to comigrate with EAT p25 in electrophoresis and to react with antibodies against the EAT p25. On the amino acid level, p25 shows about 80% sequence homology to the human stress protein hsp27. Furthermore, p25 has similar isoforms of phosphorylation as demonstrated for small mammalian stress proteins from rat and human. From the results obtained, it is concluded that p25 is a mammalian stress protein, the abundance of which is related to growth characteristics of the Ehrlich ascites tumor.

Studies on elastomeric materials with incorporated antithrombotics.

Antithrombotically effective drugs (heparin, pentosan polysulphate, streptokinase) were incorporated into elastomeric materials by means of zeolites as carrier. The incorporated antithrombotic agents can be delivered to the surrounding medium. These self-antithrombotic elastomers may be used as tubes to drain off body fluids (catheters, drains, etc.).

[Problems of exposure to organic mercury compounds in pregnancy]. / Zur Problematik der organischen Quecksilberexposition bei Schwangeren.

On account of oral intake of mercury by contaminated foodstuff (eggs eaten by pregnant women) due to non-observance of legal decisions increased mercury concentrations in the maternal and infantile blood, in the urine and hair of the mother, in the placenta, the amnion, the cord blood and the breast milk could be proved in comparison to non-exposed pregnant women. Clinical and laboratory-chemical parameters did not show any symptoms of an intoxication in mothers and children. Demands for observance of the legal decisions and avoidance of professional dealing are particularly important for pregnant women.

[Health status and management of elderly citizens of a residential district and a home for the aged in the city of Erfurt]. / Zum Gesundheitszustand und zur Betreuung älterer Bürger eines Wohnbezirkes und eines Feierabendheimes in der Stadt Erfurt.

Preservation, furtherance and recovery of health and great joy the old age - these are requests of social politics in GDR. The ageing may be influenced by a series of sanitary and social factors of risk. We have examined 100 townsmen in a home for aged people and 100 pensioners in housing-settlement of Erfurttown. The result gives a statement about state of health, about social and medical care. Illness's of systems are standing in front of heart-circulation, of respiration, of connective tissue and movement. We can not find a difference between both groups. The combinations of illness were found frequently (42%). The indigence of care in compliance with the criterions of Siggelkow and Körner are 48% from pensioneries, 39% of old aged people who got occasional good help and care. The dynamic and adapted shaping of the relation men - environment results in a positive effect. The demands on the concil in town, on social workers, on medical care and on the behaviour of the old aged people are formulated.

[Psychopathology of senile dementias in nursing home residents]. / Zur Psychopathologie der senilen Demenzen bei Pflegeheimbewohnern.

Examination of 163 nursing home residents revealed chronic brain syndrome of different amount in 84%. Demented patients with clinical evidence of arteriosclerosis had significantly higher values of emotional incontinence, dysphoria, depression and vegetative complaints than those without evidence of arteriosclerosis. Correlation of single psychopathologic parameters with other psychopathologic, neurologic and somatic variables resulted in very different correlation profiles for the following symptoms: emotional incontinence, apathy, dysphoria and euphoria. These changes in personality should be considered to a higher degree in dementia research intending more homogeneous subgroups.