Nephrolithiasis associated with embolization material, Lipiodol®, following embolization of large renal angiomyolipoma.

Angiomyolipoma (AML) is a benign renal mass that can be treated with nephron sparing surgery or transarterial embolization. Embolization has been favored due to efficacy and safety profile. This case demonstrates a previously undocumented phenomenon of AML treated with transarterial embolization using Lipiodol® (Guerbet LLC, Princeton, NJ) resulting in nephrolithiasis and retention of Lipiodol® two years after original embolization. Although Lipiodol®-based embolization has not been shown to cause nephrolithiasis, it may have been the nidus for stone formation, and this is an important potential complication worthy of further study.

Fast mapping of words and story recall by individuals with Down syndrome.

This study compared adolescents with Down syndrome to nonverbal mental-age matched controls in their ability to fast map new noun vocabulary in spoken story contexts. Context for novel words varied within subjects in the distance between mentions (close-distant) and the ease of inferring a real word for the referent (specificity). The 23 participants with Down syndrome (DS) were aged 12.8-20.3 years. The 24 typically developing (TD) children, matched on visual nonverbal mental age (MA), were 4.1 to 6.1 years old. Participants listened to 4 tape-recorded stories, each containing 3 mentions of 2 novel words in close or distant proximity and with clear or uncertain reference, and recalled each story after presentation. Fast-mapping production was measured by the occurrence of the novel word in story recall. Fast-mapping comprehension was measured by asking children to define the novel words. The DS group did not differ from the TD group in novel word production but seemed to have more difficulty with novel word definition. For both groups, novel word production was higher in the nonspecific than the specific referent condition, suggesting that availability of a real word label interfered with fast mapping. Recall of story propositions was poorer for the DS group. For both groups, story recall was better for text units not directly associated with novel words than for text units containing novel words, suggesting a trade-off effect in processing. Regression analyses indicated that syntax comprehension, rather than mean length of utterance, predicted novel word production in both groups; MA additionally contributed to predict DS story recall.