Medial open wedge osteotomy yields comparable stability to lateral open wedge procedure on the distal femur.

BACKGROUND: Supracondylar osteotomies are a frequently and successfully used technique in the treatment of coronal plane deformities and unicompartmental osteoarthritis of the knee. While lateral open wedge techniques are common for valgus deformities, the data about medial open wedge techniques for varus deformities is sparse. The aim of this study was to compare the biomechanical properties of medial and lateral open wedge osteotomies using a locking Tomofix® plate (DePuy Synthes, Oberdorf, Switzerland). Our hypothesis was that there would be no difference regarding biomechanical outcome parameters between these two groups. METHODS: Medial and lateral open wedge osteotomies were performed in composite bone model as routine. Each experimental group contained 6 constructs. Standardized osteotomy gaps of ten millimeters were performed and Tomofix® plates were fixed to third generation composite bones. The constructs were subsequently mounted into a servohydraulic testing machine. Axial and torsional loadings were applied as described in previous experimental studies. All specimens were subject to a load to failure mode with the mechanism of failure being noted. FINDINGS: Both experimental groups showed comparable biomechanical properties under axial and torsional loadings. Mean high force axial stiffness was 3772 N/mm for lateral and 4185 N/mm for the medial construct. Significant differences were noted for torsional stiffness under low- (0 N) and mid-force (150 N) loadings (P = 0.002; P = 0.009), favoring the medial open wedge constructs. INTERPRETATION: Medial open wedge osteotomy yields comparable biomechanical stability to the lateral open wedge procedure on the distal femur in a composite bone model.

Effect of design parameters in nanocatalyst synthesis on pyrolysis for producing diesel-like fuel from waste lubricating oil.

Converting waste lubricating oil into diesel-like liquid fuels using pyrolysis presents a dual solution, addressing environmental pollution while offering a viable response to the fossil energy crisis. However, achieving high-quality fuel with a substantial yield necessitates the utilization of highly active and cost-effective catalysts. We report the development of Fe-Ni nanocatalysts, synthesized using a green approach and supported on TiO2, as a promising strategy for converting waste lubricating oil into premium-grade diesel-like fuel. To ensure efficient and effective pyrolysis processes, tailoring the synthesis parameters of these nanocatalysts is indispensable. In this study, we investigate the effect of design parameters on nanocatalyst synthesis, such as the concentrations of pre-catalysts and reducing agents, reducing time, and the amount of support material, and evaluate their impact on the quality and quantity of pyrolysis products. Through optimization of the synthesis process, a high quality diesel-like fuel with a product yield of about 54% at a mild reaction temperature of 400 °C was obtained. This study highlights the critical role of nanocatalysis in addressing persistent environmental and energy challenges while showcasing the potential of green nanocatalysts in sustainable waste-to-energy conversion processes.

Treatment of osteoarthritis by implantation of Mg- and WE43-cylinders - A preclinical study on bone and cartilage changes and their influence on pain sensation in rabbits.

With its main features of cartilage degeneration, subchondral bone sclerosis and osteophyte formation, osteoarthritis represents a multifactorial disease with no effective treatment options. As biomechanical shift in the trabecular network may be a driver for further cartilage degeneration, bone enhancement could possibly delay OA progression. Magnesium is known to be osteoconductive and already showed positive effects in OA models. We aimed to use magnesium cylinders to enhance subchondral bone quality, condition of cartilage and pain sensation compared to sole drilling in vivo. After eight weeks of implantation in rabbits, significant increase in subchondral bone volume and trabecular thickness with constant bone mineral density was found indicating favored biomechanics. As representative for pain, a higher number of CD271+ vessels were present in control samples without magnesium. However, this result could not be confirmed by sensitive, objective lameness evaluation using a pressure sensing mat and no positive effect could be shown on either cartilage degeneration evaluated by OARSI score nor the presence of regenerative cells in CD271-stained samples. The presented results show a relevant impact of implanted magnesium on key structures in OA pain with missing clinical relevance regarding pain. Further studies with shifted focus should examine additional structures as joint capsule or osteophytes.

Dissolving magnesium hydroxide implants enhance mainly cancellous bone formation whereas degrading RS66 implants lead to prominent periosteal bone formation in rabbits.

Bone fractures often require internal fixation using plates or screws. Normally, these devices are made of permanent metals like titanium providing necessary strength and biocompatibility. However, they can also cause long-term complications and may require removal. An interesting alternative are biocompatible degradable devices, which provide sufficient initial strength and then degrade gradually. Among other materials, biodegradable magnesium alloys have been developed for craniofacial and orthopaedic applications. Previously, we tested implants made of magnesium hydroxide and RS66, a strong and ductile ZK60-based alloy, with respect to biocompatibility and degradation behaviour. Here, we compare the effects of dissolving magnesium hydroxide and RS66 cylinders on bone regeneration and bone growth in rabbit condyles using microtomographical and histological analysis. Both magnesium hydroxide and RS66 induced a considerable osteoblastic activity leading to distinct but different spatio-temporal patterns of cancellous and periosteal bone growth. Dissolving RS66 implants induced a prominent periosteal bone formation on the medial surface of the original condyle whereas dissolving magnesium hydroxide implants enhance mainly cancellous bone formation. Especially periosteal bone formation was completed after 6 and 8 weeks, respectively. The observed bone promoting functions are in line with previous reports of magnesium stimulating cancellous and periosteal bone growth and possible underlying signalling mechanisms are discussed. STATEMENT OF SIGNIFICANCE: Biodegradable magnesium based implants are promising candidates for use in orthopedic and traumatic surgery. Although these implants are in the scientific focus for a long time, comparatively little is known about the interactions between degrading magnesium and the biological environment. In this work, we investigated the effects of two degrading cylindrical magnesium implants (MgOH2 and RS66) both on bone regeneration and on bone growth. Both MgOH2 and RS66 induce remarkable osteoblastic activities, however with different spatio-temporal patterns regarding cancellous and periosteal bone growth. We hypothesize that degradation products do not diffuse directionless away, but are transported by the restored blood flow in specific spatial patterns which is also dependent on the used surgical technique.

[Numerical simulation in musculoskeletal biomechanics : Application perspectives and possibilities]. / Numerische Simulation in der muskuloskelettalen Biomechanik : Anwendungsperspektiven und Möglichkeiten.

BACKGROUND: Computational research methods, such as finite element analysis (FEA) and musculoskeletal multi-body simulation (MBS), are important in musculoskeletal biomechanics because they enable a better understanding of the mechanics of the musculoskeletal system, as well as the development and evaluation of orthopaedic implants. These methods are used to analyze clinically relevant issues in various anatomical regions, such as the hip, knee, shoulder joints and spine. Preoperative simulation can improve surgical planning in orthopaedics and predict individual results. EXAMPLES FROM PRACTICE: In this article, the methods of FE analysis and MBS are explained using two practical examples, and the activities of the "Numerical Simulation" cluster of the "Musculoskeletal Biomechanics Research Network (MSB-NET)" are presented in more detail. An outlook classifies numerical simulation in the age of artificial intelligence and draws attention to the relevance of simulation in the (re)approval of implants.

Very early migration of a calcar-guided short stem: a randomized study of early mobilization and the influence of a calcium phosphate coating with 60 patients.

This study analyzed the migration of a calcar-guided short stem to determine the course of very early migration, as well as evaluated the effect of an additional calcium phosphate (CP) coating on a titanium plasma spray (TPS) coating, which has not been analyzed previously. Sixty patients were enrolled in this study and were treated with the A2 calcar-guided short stem. The implant coating was randomized with either the TPS or an additional CP coating, and radiostereometric analysis was performed with the baseline measurement before initial weight-bearing, along with follow-up examinations at 1 week, 6 weeks, 3 months, and 6 months. Implant migrations were 0.27 mm (standard deviation [SD], 0.13 mm) and 0.74 mm (SD, 1.11 mm) at 1 week and 6 months post-surgery, respectively, and 65% and 87% of the implants reached their final position 1 week and 6 weeks after surgery, respectively. After 6 weeks, 3 months, and 6 months, a significant increase was noted in the migration of the CP coating group vs. that of the TPS coating group. Upon the final observation at 6 months, the groups displayed on average a 0.74-mm migration. Most of the analyzed implants ceased migration within the first week post-surgery, but the CP coating demonstrated a higher and more prolonged migration compared to the TPS coating.

[Evaluation of care for slipped capital femoral epiphysis (SCFE) in Germany]. / Analyse der Versorgungssituation bei Epiphyseolysis capitis femoris (ECF) in Deutschland.

INTRODUCTION: The treatment concept for slipped capital femoral epiphysis is still controversial. According to studies, there is currently no recommendation for a universal approach. Therefore, the aim of this study is to analyze the care reality of children with ECF in Germany. METHODS: The evaluation of the study is performed based on a questionnaire sent to physicians tending to ECF in 2021. Data is compared to the literature. RESULTS: 36 of 47 questionnaires sent out were included. Overall, no significant difference in ECF care was proven in terms of annual caseload or the size of hospital. CONCLUSION: A high variance in operative SCFE treatment is reported. According to current literature, the modified Dunn procedure is considered the best therapeutic option to date, especially for patients with severe or chronic ECF. However, compared with alternative care options, this is not feasible in every hospital due to its complicating and challenging nature. Central registration, minimum volume regulation, and expansion of continuing education measures can contribute to optimization.

Solar-driven upgrading of biomass by coupled hydrogenation using in situ (photo)electrochemically generated H2.

With the increasing pressure to decarbonize our society, green hydrogen has been identified as a key element in a future fossil fuel-free energy infrastructure. Solar water splitting through photoelectrochemical approaches is an elegant way to produce green hydrogen, but for low-value products like hydrogen, photoelectrochemical production pathways are difficult to be made economically competitive. A possible solution is to co-produce value-added chemicals. Here, we propose and demonstrate the in situ use of (photo)electrochemically generated H2 for the homogeneous hydrogenation of itaconic acid-a biomass-derived feedstock-to methyl succinic acid. Coupling these two processes offers major advantages in terms of stability and reaction flexibility compared to direct electrochemical hydrogenation, while minimizing the overpotential. An overall conversion of up to ~60% of the produced hydrogen is demonstrated for our coupled process, and a techno-economic assessment of our proposed device further reveals the benefit of coupling solar hydrogen production to a chemical transformation.

Efficient full solar spectrum-driven photocatalytic hydrogen production on low bandgap TiO2/conjugated polymer nanostructures.

The development of photocatalysts that can utilize the entire solar spectrum is crucial to achieving efficient solar energy conversion. The utility of the benchmark photocatalyst, TiO2, is limited only to the UV region due to its large bandgap. Extending the light harvesting properties across the entire spectrum is paramount to enhancing solar photocatalytic performance. In this work, we developed low bandgap TiO2/conjugated polymer nanostructures which exhibit full spectrum activity for efficient H2 production. The highly mesoporous structure of the nanostructures together with the photosensitizing properties of the conjugated polymer enabled efficient solar light activity. The mesoporous TiO2 nanostructures calcined at 550 °C exhibited a defect-free anatase crystalline phase with traces of brookite and high surface area, resulting in the best performance in hydrogen production (5.34 mmol g-1 h-1) under sunlight simulation. This value is higher not only in comparison to other TiO2-based catalysts but also to other semiconductor materials reported in the literature. Thus, this work provides an effective strategy for the construction of full spectrum active nanostructured catalysts for enhanced solar photocatalytic hydrogen production.

Pressure sensing mat as an objective and sensitive tool for the evaluation of lameness in rabbits.

In orthopaedic research, the analysis of the gait pattern is an often-used evaluation method. It allows an assessment of changes in motion sequence and pain level during postoperative follow up periods. Visual assessments are highly subjective and dependent on the circumstances. Particular challenge in rabbits is their hopping gait pattern. The aim of the present study was to establish a more objective and sensitive lameness evaluation using a pressure sensing mat. Twelve NZW rabbits were implemented in the study. They got an artificial anterior cruciate ligament transection of the right knee in connection with an experimental study, which investigated PTOA treatment. Rabbits were examined by a visual lameness score. Additionally, load of the hindlimbs was measured by the use of a pressure sensing mat and a video was recorded. Peak pressure and time force integral, defined as cumulated integral of all sensors associated to a hind paw, were evaluated. Preoperative data were collected on three independent days. As postoperative measurement time points, week 1 and week 12 after surgery were chosen. The subjective visual scoring was compared to the objective data of the pressure sensing mat. Following the visual score, lameness in week one was mild to moderate. In week twelve, rabbits were evaluated as lame free bar one. Contrary, following the values of the sensor mat, lameness in week one appeared to be more pronounced and almost all rabbits still showed low-grade lameness in week twelve. Consequently, the pressure sensing mat is more sensitive than the visual score and captures the grade of lameness much more accurately. For specific orthopaedic issues, where subtle differences in lameness are important to detect, the used system is a good supplementary evaluation method.