RESUMO
The Cherish the Family (CTF) program targets mothers with children (age 0-3) engaged in the child welfare system, and provide services to strengthen a mother's ability to care for her child. A multimodal design was used with data collected at three points of time. Program results revealed positive changes in the areas of child well-being, parental capabilities, family interactions, family safety, caregiver/child ambivalence, and readiness for reunification among the treatment group.
Assuntos
Maus-Tratos Infantis/prevenção & controle , Relações Comunidade-Instituição , Relações Mãe-Filho , Serviço Social/organização & administração , Transtornos Relacionados ao Uso de Substâncias/reabilitação , Adolescente , Adulto , Pré-Escolar , Feminino , Florida , Humanos , Lactente , Recém-Nascido , Modelos Organizacionais , Análise Multivariada , Apego ao Objeto , Análise de Regressão , Serviço Social/métodos , Adulto JovemRESUMO
Senescence marker protein 30 (SMP30) is a multifunctional protein involved in cellular Ca(2+) homeostasis and the biosynthesis of ascorbate in non-primate mammals. The primary structure of the protein is highly conserved among vertebrates, suggesting the existence of a significant physiological function common to all mammals, including primates. Enzymatic activities of SMP30 include aldonolactone and organophosphate hydrolysis. Protective effects against apoptosis and oxidative stress have been reported. X-ray crystallography revealed that SMP30 is a six-bladed ß-propeller with structural similarity to paraoxonase 1, another protein with lactonase and organophosphate hydrolase activities. SMP30 has recently been tied to several physiological conditions including osteoporosis, liver fibrosis, diabetes, and cancer. This review aims to describe the recent advances made toward understanding the connection between molecular structure, enzymatic activity and physiological function of this highly conserved, multifaceted protein.