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J Perinatol ; 35(8): 547-52, 2015 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-25927274

RESUMO

OBJECTIVE: Leptin is an adipokine that regulates energy homeostasis. The objective of this study was to establish a gestational age-specific standard for amniotic fluid leptin (AFL) levels and examine the relationship between AFL, maternal overweight and fetal growth restriction. STUDY DESIGN: Amniotic fluid was obtained at mid-gestation from singleton gravidas, and leptin was quantified using enzyme-linked immunosorbent assay. Amniotic fluid samples from 321 term pregnancies were analyzed. Clinical data, including fetal ultrasound measurements and maternal and infant characteristics, were available for a subset of patients (n=45). RESULTS: The median interquartile range AFL level was significantly higher at 14 weeks' gestation (2133 pg ml(-1) (1703 to 4347)) than after 33 weeks' gestation (519 pg ml(-1) (380 to 761), P trend<0.0001), an average difference of 102 pg ml(-1) per week. AFL levels were positively correlated with maternal pre-pregnancy body mass index (BMI) (r=0.36, P=0.03) adjusting for gestational age at measurement, but were not associated with fetal growth. CONCLUSIONS: AFL levels are higher at mid-gestation than at late gestation, and are associated with maternal pre-pregnancy BMI.


Assuntos
Líquido Amniótico/metabolismo , Retardo do Crescimento Fetal/metabolismo , Leptina/análise , Leptina/normas , Sobrepeso/metabolismo , Peso ao Nascer , Índice de Massa Corporal , Ensaio de Imunoadsorção Enzimática , Feminino , Desenvolvimento Fetal , Idade Gestacional , Humanos , Recém-Nascido , Modelos Lineares , Masculino , Placenta/patologia , Gravidez , Segundo Trimestre da Gravidez , Terceiro Trimestre da Gravidez
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