The nutcracker syndrome: its role in the pelvic venous disorders.

BACKGROUND: Symptoms of pelvic venous congestion (chronic pelvic pain, dyspareunia, dysuria, and dysmenorrhea) have been attributed to massive gonadal reflux. However, obstruction of the gonadal outflow may produce similar symptoms. Mesoaortic compression of the left renal vein (nutcracker syndrome) produces both obstruction and reflux, resulting in symptoms of pelvic congestion. We describe the diagnosis and management of nine patients studied in our institutions. MATERIALS AND METHODS: From a group of 51 female patients with pelvic congestion symptoms studied at our institutions, there were nine patients with symptoms of pelvic congestion, microscopic hematuria, and left-sided flank pain. The diagnosis of the nutcracker syndrome was suspected based on clinical examination, Doppler scan, duplex ultrasound scan, computed tomography scan, and magnetic resonance imaging. The diagnosis was confirmed by retrograde cine-video-angiography with renocaval gradient determination and catheterization of both internal iliac venous systems. All patients had a renocaval pressure gradient >4 mm Hg (normal, 0-1 mm Hg). Renal compression was relieved by external stent (ES) in two patients, internal stent (IS) in one patient, and gonadocaval bypass (GCB) in three. GCB was preceded by coil embolization of internal iliac vein tributaries connecting with lower-extremity varicose veins in three patients. Three patients deferred surgery and are under observation. Mean follow-up time was 36 months (range, 12-72 months). RESULTS: Hematuria disappeared postoperatively in all patients. ES and IS normalized the renocaval gradient and resulted in significant alleviation of symptoms (90% improvement on a scale of 0-10 where 0 = no improvement and 10 = greatest improvement). Two patients with GCB had a residual gradient of 3 mm Hg. The third patient normalized the gradient. In this group, improvement of symptoms was 60%. Patients awaiting surgery are being treated conservatively (elastic stockings, hormones, and pelvic compression). They have shown only moderate improvement. CONCLUSION: The nutcracker syndrome should be considered in women with symptoms of pelvic venous congestion and hematuria. The diagnosis is suspected by compression of the left renal vein on magnetic resonance imaging or computed tomography scan and confirmed by retrograde cine-video-angiography with determination of the renocaval gradient. Internal and external renal stenting as well as gonadocaval bypass are effective methods of treatment of the nutcracker syndrome. IS and ES were accompanied by better results than GCB. Surgical and radiologic interventional methods should be guided by the clinical, radiologic, and hemodynamic findings.

Facts and fiction surrounding the discovery of the venous valves.

Venous valves are delicate structures, the integrity of which is crucial for the normal function of the venous system. Their abnormalities lead to widespread disorders, ranging from chronic venous insufficiency to life-threatening thromboembolic phenomena. The discovery of the venous valves, however, has been the subject of hot controversy. Even though Fabricius ab Aquapendente is credited with the discovery by most historians, we demonstrate in this paper that other anatomists described them many years before Fabricius ab Aquapendente publicly demonstrated them in Padua in 1579. A thorough review of the historical literature surrounding the discovery of the venous valves was carried out from 1545 to the present under the supervision of the Medical History Department of our institution. Research was performed at the History of Medicine Division of the National Library of Medicine and through MEDLINE access to the medical literature. The Parisian Charles Estienne first mentioned the venous valves in his 1545 publication when he described "apophyses membranarum" in the veins of the liver. Lusitanus and Canano publicly demonstrated them in the azygos vein during cadaver dissections performed in Ferrera, Italy. The Parisian Jacques Sylvius described valves in the veins of the extremities in 1555. The work of these anatomists, however, could not achieve full recognition, because Andreas Vesalius, the leading anatomist at that time, was unable to confirm their findings and strongly denied the existence of venous valves. Vesalius's influence was so powerful that research on the subject was idle until 1579, when Fabricius ab Aquapendente "discovered" the venous valves. About the same time, the German Salomon Alberti published the first drawings of a venous valve (in 1585). William Harvey, a disciple of Fabricius ab Aquapendente, finally postulated the function of the venous valves, providing anatomical support for one of the greatest discoveries in medicine: the blood circulation. Therefore, our investigations revealed that Estienne and Canano discovered the venous valves in the 1530s. Fabricius ab Aquapendente's achievement was their full recognition 64 years later. However, it was not until 1628 that their function was fully understood, with the discovery of the blood circulation by William Harvey.