Left Main Ostial Compression in a Patient with Pulmonary Hypertension: Dynamic Findings by IVUS.

BACKGROUND: Pulmonary artery dilatation is a common feature among patients with severe pulmonary hypertension. Left main coronary artery extrinsic compression by an enlarged pulmonary artery is a rare complication and a potential cause for chest pain and sudden cardiac death in patients with pulmonary hypertension. This situation is very rare and few reports have described it. Currently, the appropriate management of these patients remains unknown. CASE REPORT: In the present report we describe the case of a 39-year-old woman who presented with a 2-year history of cardiac symptoms related to exercise. The patient underwent a 64-slice multidetector computed tomography (MDCT) coronary angiography, which showed left main coronary artery (LMCA) compression by a markedly enlarged pulmonary artery trunk (44 mm), without intraluminal stenosis or coronary artery calcium, as determined by the Agatston score. This compression was considered to be the cause of the cardiac symptoms. To confirm and plan the treatment, the patient underwent cardiac catheterization that confirmed the diagnosis of pulmonary hypertension and LMCA critical obstruction. Taking into account the paucity of information regarding the best management in these cases, the treatment decision was shared among a "heart team" that chose percutaneous coronary intervention with stent placement. An intra-vascular ultrasound was performed during the procedure, which showed a dynamic compression of the left main coronary artery. The intervention was successfully executed without any adverse events. CONCLUSIONS: This case illustrates dynamic compression of the LMCA by IVUS, visually demonstrating the mechanism of the intermittent symptoms of myocardial ischemia in this kind of patient. It also shows that percutaneous stenting technique may be an appropriate treatment for this unusual situation.

Stress myocardial perfusion imaging by CMR provides strong prognostic value to cardiac events regardless of patient's sex.

OBJECTIVES: The major aim of this study is to test the hypothesis that stress cardiac magnetic resonance (CMR) imaging can provide robust prognostic value in women presenting with suspected ischemia, to the same extent as in men. BACKGROUND: Compelling evidence indicates that women with coronary artery disease (CAD) experience worse outcomes than men owing to a lack of early diagnosis and management. Numerous clinical studies have shown that stress CMR detects evidence of myocardial ischemia and infarction at high accuracy. Compared to nuclear scintigraphy, CMR is free of ionizing radiation, has high spatial resolution for imaging small hearts, and overcomes breast attenuation artifacts, which are substantial advantages when imaging women for CAD. METHODS: We performed stress CMR in 405 patients (168 women, mean age 58 ± 14 years) referred for ischemia assessment. CMR techniques included cine cardiac function, perfusion imaging during vasodilating stress, and late gadolinium enhancement imaging. All patients were followed for major adverse cardiac events (MACE). RESULTS: At a median follow-up of 30 months, MACE occurred in 36 patients (9%) including 21 cardiac deaths and 15 acute myocardial infarctions. In women, CMR evidence of ischemia (ISCHEMIA) demonstrated strong association with MACE (unadjusted hazard ratio: 49.9, p < 0.0001). While women with ISCHEMIA(+) had an annual MACE rate of 15%, women with ISCHEMIA(-) had very low annual MACE rate (0.3%), which was not statistically different from the low annual MACE rate in men with ISCHEMIA(-) (1.1%). CMR myocardial ischemia score was the strongest multivariable predictor of MACE in this cohort, for both women and men, indicating robust cardiac prognostication regardless of sex. CONCLUSIONS: In addition to avoiding exposure to ionizing radiation, stress CMR myocardial perfusion imaging is an effective and robust risk-stratifying tool for patients of either sex presenting with possible ischemia.

Cardiac magnetic resonance imaging as a prognostic tool in patients with nonischemic cardiomyopathy.

Technical advancements have enabled cardiac magnetic resonance (CMR) imaging to provide a noninvasive assessment of cardiomyopathy. Cardiac magnetic resonance imaging acts as the reference standard for quantifying left and right ventricular function. It also assesses the etiology of cardiomyopathy by demonstrating the presence and size of myocardial scar and by detecting myocardial inflammation and interstitial infiltration. Cardiomyopathy can result in early mortality and arrhythmic risk, and CMR imaging aids in risk stratification among this group of patients. Left ventricular ejection fraction predicts which patients will benefit most from implantable cardioverter-defibrillators (ICDs), but this is not a perfect marker of arrhythmic risk. The etiology of cardiomyopathy, as assessed with CMR imaging, adds further prognostic information with infiltrative cardiomyopathies, resulting in higher mortality than idiopathic cardiomyopathies. Among patients with nonischemic cardiomyopathy (NICM), the degree of fibrosis as determined by the CMR imaging sequence of late gadolinium enhancement (LGE) imaging offers further prognostic information. Late gadolinium enhancement imaging in patients with NICM portends an approximately 3- to 8-fold greater risk of death or hospitalization than NICM without LGE imaging. Further research is needed to determine if the presence of LGE will be helpful in predicting which patients may benefit from ICD implantation.