1.
Chem Commun (Camb)
; 57(95): 12816-12819, 2021 Nov 30.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34783801
RESUMO
G-quadruplex (G4) binding proteins regulate important biological processes, but their interaction networks are poorly understood. We report the first use of G4 as a warhead of a proteolysis-targeting chimera (G4-PROTAC) for targeted degradation of a G4-binding protein (RHAU/DHX36). G4-PROTAC provides a new way to explore G4-protein networks and to develop potential therapeutics.