[PH-sensitive cationic lipopeptides for the design of drug-delivery systems].

Lipopeptides on the basis of L-glutamic acid and glutamine di- and monoesters with aliphatic alcohols of various lengths that contain L-arginine, L-ornithine, and L-lysine were synthesized. The behavior of these amphiphiles in aqueous medium was shown to depend on their structure.

[Synthesis of lipophilic RGD-peptide derivatives]. / Sintez lipofil'nogo proizvoddnogo RGD-peptida.

Bishexadecyl ester of RDG peptide was synthesized in solution by the conventional methods of peptide chemistry in a total yield of 48%. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2004, vol. 30, no. 2; see also http://www.maik.ru.

[Conjugates of porphyrins with carbohydrates]. / Kon''iugaty porfirinov s uglevodami.

The methods of synthesis and properties of prophyrins covalently linked with carbohydrates are considered. Special attention is paid to the prospects of using this class of compounds as photosensitizers in photodynamic cancer therapy.

[Synthesis and properties of O- and S-glycosylated derivatives of pyropheophorbide a]. / Sintez i izuchenie svoistv O- i S-glikozilirovannykh proizvodnykh pirofeoforbida a.

New O- and S-glycosylated derivatives of pyropheophorbide a were synthesized in the context of the design of photosensitizers for photodynamic cancer therapy. The resulting amphiphilic conjugates were found to be sufficiently water-soluble and suitable for the study of the photosensitizer penetration and accumulation in tumors.

[The synthesis of galactopyranosyl-substituted derivatives of pheophorbide]. / Sintez galaktopiranozilzameshchennykh proizvodnykh feoforbida.

New pheophorbide and pyropheophorbide derivatives containing carbohydrate fragments, derivatives of galactopyranose, were synthesized. Galactopyranosylpheophorbide and galactopyranosylpyropheophorbide with free hydroxyl groups were found to be water-soluble and useful as sensitizers in photodynamic therapy of cancer.

[Synthesis of a modified analog of a native lipotripeptide from the E. coli bacterial wall]. / Sintez modifitsirovannogo analoga prirodnogo lipotripeptida iz bakterial'noi stenki E. coli.

The following prospective immunomodulators, aliphatic derivatives of amino acids and peptides, were synthesized: N-palmitoyl-L-cysteine, N-palmitoyl-S-[1,2-bis(hexadecyloxycarbonyl)ethyl]-L-cysteine, N-palmitoyl-S-[1,2-bis(hexadecyloxycarbonyl)ethyl]-L-cysteinyl-L-s erine, and N-palmitoyl-S-[1,2-bis(hexadecyloxycarbonyl) ethyl]-L-cysteinyl-L-seryl-L-serine.

[Model systems based on the lipid-porphyrin assemblies and lipoproteins in biochemical studies]. / Model'nye sistemy na osnove lipid-porfirinovykh ansamblei i lipoporfirinov v biokhimicheskikh issledovaniiakh.

Reviewed are the modern state and prospects of using lipid-porphyrin assemblies and lipoporphyrins to study fine functional mechanisms of complex biological systems and to solve applied problems in biochemistry and medicine. Data on the interaction of porphyrin derivatives with natural and artificial membranes are summarized. Models for electron transfer and oxygen transport via lipid-porphyrin assemblies are discussed.

[Solubilization of myxovirus surface glycoproteins by using a nonionic detergent octylglucoside]. / Soliubilizatsiia poverkhnostnykh glikoproteidov miksovirusov s pomoshch'iu neionnogo detergenta oktilgliukozida.

Using alpha- and beta-forms of the non-ionic detergent octyl glucoside the conditions have been developed for treatment of influenza virus and Sendai virus suspensions with the purpose of solubilization from virions of exclusively surface glycoproteins. Both alpha- and beta-forms of the detergent have been shown to have similar effectiveness for the recovery of chromatographically pure preparations of surface glycoproteins.