RESUMO
Most clinical trials investigating prevention of seasickness with transdermal scopolamine have been short-term, and little information regarding long-term use is available. We report here a double-blind trial conducted on board a flat-bottomed Republic of Singapore Navy vessel of 2,490 tons, sailing in the South China Sea. The trip lasted 26 d, but self-assessment by the 122 adult male participants (using a simplified scale quantifying the level of seasickness) was confined to the 18 d spent at sea. We found that the protection rate with transdermal scopolamine was 46-57%, with maximum benefits to inexperienced participants, during the early preadaptation phase, or in rough seas even after adaptation. Unwanted effects were few and generally minor. We concluded that the benefits of Scopoderm were worth exploiting even for long trips in moderate-to-rough seas.
Assuntos
Militares , Enjoo devido ao Movimento/prevenção & controle , Escopolamina/administração & dosagem , Administração Cutânea , Adulto , Ensaios Clínicos como Assunto , Método Duplo-Cego , Humanos , Masculino , Escopolamina/uso terapêutico , Singapura , Fatores de TempoRESUMO
In an eosinophilic population of 47 boys of the same age, a large proportion (92%) were helminth infested or atopic, or both, compared with 36% of 36 controls. The methods used to detect these conditions were not costly or elaborate, except for the radioallergosorbent test, which was used to measure concentrations of circulating IgE antibodies to atopic allergens. It is suggested that an economical approach to detect helminthiasis and atopy in cases of eosinophilia is adopted using the methods employed here, with skin prick tests replacing the radioallergosorbent test.
Assuntos
Eosinofilia/etiologia , Adolescente , Filariose/complicações , Helmintíase/complicações , Helmintíase/diagnóstico , Humanos , Hipersensibilidade Imediata/complicações , Hipersensibilidade Imediata/diagnóstico , Imunoglobulina E/metabolismo , Contagem de Leucócitos , Masculino , Fumar , Toxocaríase/complicaçõesRESUMO
Among 990 young male adolescents studied, only 7 were anemic. Three of the anemics had beta-thalassemia trait and 4 had probable alpha-thalassemia trait. Forty-six individuals with hemoglobinopathies were detected: 29 with probable alpha-thalassemia trait, 10 with beta-thalassemia trait and 7 with heterozygous HbE. Heterozygous alpha and beta-thalassemia occurred predominantly in Chinese while heterozygous HbE was found entirely in Malays. There were no cases of established iron deficiency anemia and only 1 had iron deficient erythropoiesis. Folate deficiency occurred only in 8 subjects with thalassemia traits, and no vitamin B12 deficiency was detected.
Assuntos
Etnicidade , Talassemia/genética , Adolescente , Hemoglobina Fetal/genética , Ácido Fólico/sangue , Triagem de Portadores Genéticos , Hemoglobina A2/genética , Hemoglobina E/genética , Hemoglobina H/genética , Hemoglobinometria , Humanos , Ferro/sangue , Masculino , Singapura , Talassemia/sangue , Vitamina B 12/sangueAssuntos
Medicina Militar , Poliomielite/imunologia , Adolescente , Adulto , Humanos , Imunização , Masculino , Testes Sorológicos , SingapuraAssuntos
Marcha , Locomoção , Medicina Militar , Frequência Cardíaca , Humanos , Resistência Física , Esforço FísicoRESUMO
A study is conducted on the incidence of false positive results in the serological test for syphilis in 300 military recruits following smallpox immunization. It is found that 3.7% of individuals developed false reactivity in the V D R L Slide test. The false reactivity appeared two to four weeks following immunization, and disappeared from two to eight weeks later. All reactive sera were negative in the FTA-ABS test.
