RESUMO
This review deals with natural selection operating on heterozygotes as a key factor controlling (a) the frequency of immunodeficiencies, and (b) promoter polymorphism in MHC class II genes. The known difference in frequency distribution of X-linked and autosomal deficiencies lend support to this possibility, and suggest that the frequency of neonatal defect may rise as old-established equlibria between entry and exit of deleterious mutations change. MHC class II gene promoters differ in their capacity to favor Th1 (or reciprocally Th2) responses, thus suggesting that promoter polymorphism is sustained by the greater flexibility in response that this confers on heterozygotes.
Assuntos
Genes MHC da Classe II/genética , Imunodeficiência Combinada Severa/imunologia , Animais , Heterozigoto , Humanos , Camundongos , Polimorfismo Genético , Regiões Promotoras Genéticas , Seleção Genética , Imunodeficiência Combinada Severa/genéticaRESUMO
Communication barriers erected by grieving children delay problem resolution. Use of the expressive arts--music, art, and body movement--in symbolic communication helps them to express overwhelming feelings and cope with trauma and stress.
Assuntos
Atitude Frente a Morte , Pesar , Arteterapia , Criança , Pré-Escolar , Barreiras de Comunicação , Humanos , MusicoterapiaRESUMO
A survey was conducted to determine dietitians' attitudes toward and readiness for advocacy. Representative members of an affiliated state dietetic association expressed positive attitudes toward the professional's assumption of the advocate role. The respondents looked to the national, state, and local dietetic associations to provide leadership in the area of advocacy.
