Reducing blood flow pulsation artifacts in 3D time-of-flight angiography by locally scrambling the order of the acquisition at 3 T and 7 T.

PURPOSE: Non-contrast-enhanced time of flight (TOF) is a standard method for magnetic resonance angiography used to depict vessel morphology. TOF is commonly performed with a 3D steady-state acquisition, employing a short repetition time to support high resolution imaging. At 7 T, TOF exhibits substantial increase in SNR and contrast, improving its clinical value. However, one of the remaining challenges, exacerbated at 7 T, is the presence of artifacts due to pulsatile blood flow, especially near major blood vessels. In this study we examine a method to significantly reduce these artifacts. METHODS: We recently introduced a new "local-scrambling" approach that semi-randomizes the acquisition order of the phase encodes, to achieve a controllable cutoff frequency above which the artifacts are drastically reduced. With this approach, artifacts resulting from fast local fluctuations such as cardiac pulsation are significantly reduced. In this study, we explore the ability of this local-scrambling approach to reduce pulsatile blood flow artifacts in a 3D TOF acquisition. Cartesian line-by-line and center-out ordering, with and without local-scrambling, were compared in simulations and in human brain imaging at 3 and 7 T scanners. RESULTS: In the simulations the artifact intensity showed a 10-fold reduction using local-scrambling compared to line-by-line and 4-fold compared to center-out ordering. In vivo results show that artifacts are much more pronounced at 7 T compared to 3 T, and in both cases they are effectively reduced by local-scrambling. CONCLUSION: Local-scrambling improves image quality for both line-by-line and center-out ordering. This approach can easily be implemented in the scanner without any changes to the reconstruction.

Messing up to clean up: Semi-randomized frequency selective space-filling curves to suppress physiological signal fluctuations in MRI.

PURPOSE: Rapid 3D steady-state sequences are widely used but are also known to be sensitive to semi-periodic physiological signal fluctuations due to, for example, cardiac pulsation, breathing, and eye/eyelids movement. This semi-periodicity results in repeating artifacts in the image whose intensity depends on the scan parameters. The purpose of this study is to design a reordering of the 2D phase encodes (within the 3D acquisition) that reduces these artifacts. METHODS: A randomized order of the phase encodes can suppress repeating artifact but may also introduce its own apparent noise, for example, in cases of slow subject movement or gradual changes in eddy currents. In a new design a semi-randomized space-filling curve is generated by scrambling the local order of the phase encodes to achieve a controlled frequency selective effect, that is, eliminating artifacts above a chosen (fluctuation) frequency threshold while leaving lower frequencies untouched, thus overcoming the limitations of a randomized order. The method was characterized in simulations and substantiated by human brain imaging at 7 T using two steady-state gradient echo variants that suffer from pulsation, either near blood vessels or near the ventricles. RESULTS: The simulations with a point source show that the maximum artifact intensity can be reduced by factors of 10-50 depending on the scan parameters. In human scanning, the new approach drastically reduced physiologically induced artifacts and was superior in this regard to both full randomization and a generalized Hilbert curve, another semi-randomized approach. CONCLUSION: The phase-encodes reordering presented here effectively removes artifacts arising from local fluctuations.

Adaptive model-based Magnetic Resonance.

PURPOSE: Conventional sequences are static in nature, fixing measurement parameters in advance in anticipation of a wide range of expected tissue parameter values. We set out to design and benchmark a new, personalized approach-termed adaptive MR-in which incoming subject data is used to update and fine-tune the pulse sequence parameters in real time. METHODS: We implemented an adaptive, real-time multi-echo (MTE) experiment for estimating T2 s. Our approach combined a Bayesian framework with model-based reconstruction. It maintained and continuously updated a prior distribution of the desired tissue parameters, including T2 , which was used to guide the selection of sequence parameters in real time. RESULTS: Computer simulations predicted accelerations between 1.7- and 3.3-fold for adaptive multi-echo sequences relative to static ones. These predictions were corroborated in phantom experiments. In healthy volunteers, our adaptive framework accelerated the measurement of T2 for n-acetyl-aspartate by a factor of 2.5. CONCLUSION: Adaptive pulse sequences that alter their excitations in real time could provide substantial reductions in acquisition times. Given the generality of our proposed framework, our results motivate further research into other adaptive model-based approaches to MRI and MRS.

Artifact suppression in readout-segmented consistent K-t space EPSI (RS-COKE) for fast 1 H spectroscopic imaging at 7 T.

PURPOSE: Fast proton (1 H) MRSI is an important diagnostic tool for clinical investigations, providing metabolic and spatial information. MRSI at 7 T benefits from increased SNR and improved separation of peaks but requires larger spectral widths. RS-COKE (Readout-Segmented Consistent K-t space Epsi) is an echo planar spectroscopic imaging (Epsi) variant capable to support the spectral width required for human brain metabolites spectra at 7 T. However, mismatches between readout segments lead to artifacts, particularly when subcutaneous lipid signals are not suppressed. In this study, these mismatches and their effects are analyzed and reduced. METHODS: The following corrections to the data were performed: i) frequency-dependent phase corrections; ii) k-space trajectory corrections, derived from short reference scans; and iii) smoothing of data at segment transitions to mitigate the effect of residual mismatches. The improvement was evaluated by performing single-slice RS-COKE on a head-shaped phantom with a "lipid" layer and healthy subjects, using varying resolutions and durations ranging from 4.1 × 4.7 × 15 mm3 in 5:46 min to 3.1 × 3.3 × 15 mm3 in 13:07 min. RESULTS: Artifacts arising from the readout-segmented acquisition were substantially reduced, thus providing high-quality spectroscopic imaging in phantom and human scans. LCModel fitting of the human data resulted in a relative Cramer-Rao lower bounds within 6% for NAA, Cr, and Cho images in the majority of the voxels. CONCLUSION: Using the new reference scans and reconstruction steps, RS-COKE was able to deliver fast 1 H MRSI at 7 T, overcoming the spectral width limitation of standard EPSI at this field strength.

Phase-based fast 3D high-resolution quantitative T2 MRI in 7 T human brain imaging.

Magnetic resonance imaging (MRI) is a powerful and versatile technique that offers a range of physiological, diagnostic, structural, and functional measurements. One of the most widely used basic contrasts in MRI diagnostics is transverse relaxation time (T2)-weighted imaging, but it provides only qualitative information. Realizing quantitative high-resolution T2 mapping is imperative for the development of personalized medicine, as it can enable the characterization of diseases progression. While ultra-high-field (≥ 7 T) MRI offers the means to gain new insights by increasing the spatial resolution, implementing fast quantitative T2 mapping cannot be achieved without overcoming the increased power deposition and radio frequency (RF) field inhomogeneity at ultra-high-fields. A recent study has demonstrated a new phase-based T2 mapping approach based on fast steady-state acquisitions. We extend this new approach to ultra-high field MRI, achieving quantitative high-resolution 3D T2 mapping at 7 T while addressing RF field inhomogeneity and utilizing low flip angle pulses; overcoming two main ultra-high field challenges. The method is based on controlling the coherent transverse magnetization in a steady-state gradient echo acquisition; achieved by utilizing low flip angles, a specific phase increment for the RF pulses, and short repetition times. This approach simultaneously extracts both T2 and RF field maps from the phase of the signal. Prior to in vivo experiments, the method was assessed using a 3D head-shaped phantom that was designed to model the RF field distribution in the brain. Our approach delivers fast 3D whole brain images with submillimeter resolution without requiring special hardware, such as multi-channel transmit coil, thus promoting high usability of the ultra-high field MRI in clinical practice.

Reducing SAR in 7T brain fMRI by circumventing fat suppression while removing the lipid signal through a parallel acquisition approach.

Ultra-high-field functional magnetic resonance imaging (fMRI) offers a way to new insights while increasing the spatial and temporal resolution. However, a crucial concern in 7T human MRI is the increase in power deposition, supervised through the specific absorption rate (SAR). The SAR limitation can restrict the brain coverage or the minimal repetition time of fMRI experiments. In the majority of today's studies fMRI relies on the well-known gradient-echo echo-planar imaging (GRE-EPI) sequence, which offers ultrafast acquisition. Commonly, the GRE-EPI sequence comprises two pulses: fat suppression and excitation. This work provides the means for a significant reduction in the SAR by circumventing the fat-suppression pulse. Without this fat-suppression, however, lipid signal can result in artifacts due to the chemical shift between the lipid and water signals. Our approach exploits a reconstruction similar to the simultaneous-multi-slice method to separate the lipid and water images, thus avoiding undesired lipid artifacts in brain images. The lipid-water separation is based on the known spatial shift of the lipid signal, which can be detected by the multi-channel coils sensitivity profiles. Our study shows robust human imaging, offering greater flexibility to reduce the SAR, shorten the repetition time or increase the volume coverage with substantial benefit for brain functional studies.

Combining multiband slice selection with consistent k-t-space EPSI for accelerated spectral imaging.

PURPOSE: To design and implement a multislice MRSI method for fast spectroscopic imaging, using a modified version of echo planar spectroscopic imaging (EPSI) that offers higher spectral width and/or shorter scan time. METHODS: Echo planar spectroscopic imaging suffers from inconsistencies between readout lines acquired with gradients of opposite signs, which has typically been addressed by reconstructing the "positive" and "negative" data sets separately and averaging the two. Nevertheless, consistency between the readout lines of each phase encode can be achieved by interposing the EPSI readouts with alternating "blipped" phase-encode gradients. This method exchanges inconsistencies along the temporal dimension with inconsistencies along the phase-encode dimension, which are straightforward to correct, as is conventionally done in various EPI reconstruction schemes. Such consistent k-t-space EPSI doubles the spectral width in comparison to EPSI, or, in an alternative realization, yields the same spectral width as EPSI, but at half the acquisition time. In this work, multiband CAIPIRINHA (controlled aliasing in parallel imaging results in higher acceleration) slice selection was integrated with consistent k-t-space EPSI to further accelerate the measurement 2-fold. RESULTS: The feasibility of a consistent k-t-space EPSI was demonstrated in both phantoms and in vivo brain imaging at 3 T, and four pulse scheme variants were evaluated. It was demonstrated to be useful in optimizing the spectral width and scan acceleration, both of which are limiting factors in vivo. Dual-band implementation was shown to shorten the duration of the scan 4-fold. CONCLUSION: The consistent k-t-space EPSI can be used to accelerate MRSI or, alternatively, double its spectral width. Adding dual-band CAIPIRINHA further accelerates the acquisition by a factor of 2.

Single-scan MRI with exceptional resilience to field heterogeneities.

PURPOSE: Single-scan two-dimensional MRI has been generally constrained to acquisitions in high quality magnets. This study introduces a methodology, cross-term spatiotemporal encoding (xSPEN), that delivers such images under much poorer external field conditions. METHODS: xSPEN departs from conventional k-space scanning, by relying on spatiotemporally encoding the image being sought. Unlike hitherto proposed SPEN methods, however, xSPEN's image readout does not take place using a field gradient along the direction being probed, but rather with the aid of an ancillary source of inhomogeneous frequency broadening. This ancillary dimension was here imposed by an orthogonal field gradient; for example, images along the "y" axis were read out by application of a "z" gradient. The principles and characteristics of this new approach, compatible with existing scanners and free from the need to collect auxiliary information such as field maps, are presented and discussed. RESULTS: Single- and multi-slice in vitro, ex vivo, and in vivo MRI experiments, confirmed the unusual resilience of this new single-shot MRI method to multiple chemical sites on phantoms, animals and humans. CONCLUSION: xSPEN can deliver single-scan MRI with good sensitivity and exceptional resilience to field inhomogeneities. This could enable investigations that have hitherto escaped from MRI's scope. Magn Reson Med 77:623-634, 2017. © 2016 International Society for Magnetic Resonance in Medicine.

Acquiring and processing ultrafast biomolecular 2D NMR experiments using a referenced-based correction.

Thanks to their special spatiotemporal encoding/decoding scheme, ultrafast (UF) NMR sequences can deliver arbitrary 2D spectra following a single excitation. Regardless of their nature, these sequences have in common their tracing of a path in the [Formula: see text]-[Formula: see text] plane, that will deliver the spectrum being sought after a 1D Fourier transformation versus [Formula: see text]. This need to simultaneously digitize two domains, tends to impose bandwidth limitations along all spectral axes. Along the [Formula: see text]/[Formula: see text] dimension this problem is exacerbated by the fact that odd and even time points are not equispaced, and by additional artifacts such as time shifts between time points sampled while under the action of positive and negative decoding gradients. As a result, odd and even [Formula: see text] points are typically Fourier transformed separately, halving the potential spectral width along this dimension. While this halving of the [Formula: see text] span can be overcome by an interlaced Fourier transform, this post-processing is seldom used because of its sensitivity to hardware inaccuracies requiring even finer corrections of the even/odd [Formula: see text] data points. These corrections have so far been done manually, but are challenging to implement when dealing with low signal-to-noise ratio signals like those associated with biomolecular NMR experiments. This study introduces an algorithm for an automatic correction of all even/odd ultrafast NMR inconsistencies, based on the acquisition of a reference scan on the solvent. This algorithm was verified experimentally using an [Formula: see text]-[Formula: see text] UF-HSQC variant on ubiquitin at 600 MHz. Features of this method as well as of the interlaced Fourier transformation in general, are discussed.

Interleaved multishot imaging by spatiotemporal encoding: A fast, self-referenced method for high-definition diffusion and functional MRI.

PURPOSE: Single-shot imaging by spatiotemporal encoding (SPEN) can provide higher immunity to artifacts than its echo planar imaging-based counterparts. Further improvements in resolution and signal-to-noise ratio could be made by rescinding the sequence's single-scan nature. To explore this option, an interleaved SPEN version was developed that was capable of delivering optimized images due to its use of a referenceless correction algorithm. METHODS: A characteristic element of SPEN encoding is the absence of aliasing when its signals are undersampled along the low-bandwidth dimension. This feature was exploited in this study to segment a SPEN experiment into a number of interleaved shots whose inaccuracies were automatically compared and corrected as part of a navigator-free image reconstruction analysis. This could account for normal phase noises, as well as for object motions during the signal collection. RESULTS: The ensuing interleaved SPEN method was applied to phantoms and human volunteers and delivered high-quality images even in inhomogeneous or mobile environments. Submillimeter functional MRI activation maps confined to gray matter regions as well as submillimeter diffusion coefficient maps of human brains were obtained. CONCLUSION: We have developed an interleaved SPEN approach for the acquisition of high-definition images that promises a wider range of functional and diffusion MRI applications even in challenging environments.

Overcoming limitations in diffusion-weighted MRI of breast by spatio-temporal encoding.

PURPOSE: Evaluating the usefulness of diffusion-weighted spatio-temporal encoding (SPEN) methods to provide quantitative apparent diffusion coefficient (ADC)-based characterizations of healthy and malignant human breast tissues, in comparison with results obtained using techniques based on spin-echo echo planar imaging (SE-EPI). METHODS: Twelve healthy volunteers and six breast cancer patients were scanned at 3T using scanner-supplied diffusion-weighted imaging EPI sequences, as well as two fully refocused SPEN variants programmed in-house. Suitable codes were written to process the data, including calculations of the actual b-values and retrieval of the ADC maps. RESULTS: Systematically better images were afforded by the SPEN scans, with negligible geometrical distortions and markedly weaker ghosting artifacts arising from either fat tissues or from strongly emitting areas such as cysts. SPEN-derived images provided improved characterizations of the fibroglandular tissues and of the lesions' contours. When translated into the calculation of the ADC maps, there were no significant differences between the mean ADCs derived from SPEN and SE-EPI: if reliable images were available, both techniques showed that ADCs decreased by nearly two-fold in the malignant lesion areas. CONCLUSION: SPEN-based sequences yielded diffusion-weighted breast images with minimal artifacts and distortions, enabling the calculation of improved ADC maps and the identification of decreased ADCs in malignant regions.

Referenceless reconstruction of spatiotemporally encoded imaging data: principles and applications to real-time MRI.

PURPOSE: Ultrafast sequences based on "Hybrid" spatiotemporal encoding (SPEN) replace echo-planar imaging's phase encoding "blips," while retaining a k-space readout acquisition. Hardware imperfections during acquisition may lead to ghosts and striped artifacts along the SPEN dimension; akin to echo-planar imaging's Nyquist ghosts, but weaker. A referenceless method to eliminate these artifacts in Hybrid SPEN is demonstrated. THEORY AND METHODS: Owing to its encoding in direct space, rather than reciprocal space, undersampling in SPEN does not generate an echo-planar-imaging-like aliasing, but instead lowers the spatial resolution. Hybrid SPEN data can be split into two undersampled signals: a reference one comprised of the odd-echos, and an even-echo set that has to be "corrected" for consistency with the former. A simple way of implementing such a correction that enables a joint high-resolution reconstruction is proposed. RESULTS: The referenceless algorithm is demonstrated with various examples, including oblique scans, large in vivo datasets from real-time dynamic contrast-enhanced perfusion experiments, and human brain imaging. CONCLUSIONS: The referenceless correction enables robust single-scan imaging under changing conditions-such as patient motion and changes in shimming over time-without the need of ancillary navigators. This opens new options for real-time MRI and interactive scanning.

Super-resolved parallel MRI by spatiotemporal encoding.

Recent studies described an "ultrafast" scanning method based on spatiotemporal (SPEN) principles. SPEN demonstrates numerous potential advantages over EPI-based alternatives, at no additional expense in experimental complexity. An important aspect that SPEN still needs to achieve for providing a competitive ultrafast MRI acquisition alternative, entails exploiting parallel imaging algorithms without compromising its proven capabilities. The present work introduces a combination of multi-band frequency-swept pulses simultaneously encoding multiple, partial fields-of-view, together with a new algorithm merging a Super-Resolved SPEN image reconstruction and SENSE multiple-receiving methods. This approach enables one to reduce both the excitation and acquisition times of sub-second SPEN acquisitions by the customary acceleration factor R, without compromises in either the method's spatial resolution, SAR deposition, or capability to operate in multi-slice mode. The performance of these new single-shot imaging sequences and their ancillary algorithms were explored and corroborated on phantoms and human volunteers at 3 T. The gains of the parallelized approach were particularly evident when dealing with heterogeneous systems subject to major T2/T2* effects, as is the case upon single-scan imaging near tissue/air interfaces.