Parotid-gland-sparing 3D conformal radiotherapy in patients with bilateral radiotherapy of the head and neck region--results in clinical practice.

The aim was to improve the prediction rate of hyposalivation after using a modern 3D-conformal-radiotherapy-technique (3D-CRT) by sparing of the contralateral parotid gland. Between June 2002 and October 2006, 107 patients (90 male, 17 female, average age: 58 years) with squamous cell carcinoma of the head and neck were included in a prospective, non-randomized study. All patients were treated using 3D-CRT. Parotid function was assessed by measuring stimulated salivary flow before, during and at the end of radiotherapy, as well as 1, 6 and 12 months after radiotherapy. Measurements were converted to flow rates and normalized relative to that before treatment. Mean doses (D(mean)) were calculated from dose-volume histograms (DVHs) based on computed tomographies (CTs) for the left and right parotid gland separately. Patients were grouped according to the D(mean) of the lowest irradiated parotid gland. Group I included all patients who received a D(mean)<26Gy (n=23), group II D(mean) 26-40Gy (n=38) and group III D(mean)>40Gy (n=46). By the time of 6 months after irradiation, salivary flow rates decreased continuously during the therapy. In group I the flow rate decreased to 59%, in group II to 40% and in group III to 14%, p<0.05. One year after irradiation a recovery effect could be measured in all groups. A sufficient saliva flow rate can be proven if one parotid gland is spared with a D(mean) dose <26Gy. Approximately, one quarter of the participants showed a significant improvement.

[Assessment of cognitive function after preventive and therapeutic whole brain irradiation using neuropsychological testing]. / Erfassung kognitiver Funktionen nach prophylaktischer und therapeutischer Ganzhirnbestrahlung mittels neuropsychologischer Testverfahren.

PURPOSE: Aim of this study was the assessment of neuropsychological changes after whole brain irradiation. PATIENTS AND METHOD: 64 patients were tested before, and 29 after whole brain irradiation, including 28 patients with small cell lung cancer (SCLC) before prophylactic cranial irradiation (PCI) and 36 patients with cerebral metastases before therapeutic cranial irradiation (TCI), as well as 14 patients after PCI and 15 after TCI (Table 1). Intelligence, attention and memory were assessed applying a 90-minute test battery of standardized, neuropsychological tests (Table 3). RESULTS: Patients with SCLC showed test results significantly below average before PCI (n = 28, mean IQ = 83, SD = 17). Neither after PCI, nor after TCI the tested neuropsychological functions decreased significantly (Tables 4, 5). A comparison between SCLC-patients with and without cerebral metastases before whole brain irradiation showed better test-results in patients with cerebral metastases and fewer cycles of preceding chemotherapy (Table 7). CONCLUSION: Neuropsychological capacity in patients with SCLC was impaired even before PCI. Possible reason is the preceding chemotherapy. Whole brain irradiation did not induce a significant decline of cognitive functions in patients with PCI or TCI. A decline in a longer follow-up nevertheless seems possible.