1.
Gene Ther
; 14(17): 1305-8, 2007 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17625576
RESUMO
The ability to affect gene expression via topical therapy has profound therapeutic implications for conditions characterized by open wounds including cutaneous neoplasms, thermal injury, skin disorders and dysfunctional wound healing. Specifically targeting local gene expression avoids systemic toxicity and simplifies treatment. We have developed a new method of topical matrix-based short interfering RNA application to precisely and effectively silence local gene expression in nondelimited wounds.