[Local treatment of malignant pleural effusion in gynecologic tumors]. / Die lokale Behandlung maligner Pleuraergüsse bei gynäkologischen Tumoren.

Pleural effusions are a frequent complication of malignant gynecologic diseases, especially in breast cancer with an incidence of about 50%. Pleural effusions usually occur at a stage of the disease where no further curative therapeutic options exist. Therefore, the treatment should be effective and have a low side effect profile. The intrapleural administration of mitoxantrone in comparison with other pleurodesis techniques has been demonstrated to meet these requirements.

[Local treatment of malignant pleural effusion in gynecologic tumors]. / Die lokale Behandlung maligner Pleuraergüsse bei gynäkologischen Tumoren.

Pleural effusions are a frequent complication of malignant gynecologic diseases, especially in breast cancer with an incidence of about 50%. Pleural effusions usually occur at a stage of the disease where no further curative therapeutic options exist. Therefore, the treatment should be effective and have a low side effect profile. The intrapleural administration of mitoxantrone in comparison with other pleurodesis techniques has been demonstrated to meet these requirements.

[Myeloreticulosis of the uterus following acute myeloid leukemia]. / Myeloretikulose des Uterus nach akuter myeloischer Leukämie.

Tumorous manifestations of myelosis with or without leukemia are rarely seen today as they appear at a very late stage of the disease. They are of importance to the gynecologist in the differential diagnoses concerning the breast, the endometrium and uterus, the placenta and the fetus. The case report of a myeloreticulosis of the uterus, three years after an acute myeloid leukemia was treated, is described.

[Clinical aspects of laryngopathia gravidarum]. / Zur Klinik der Laryngopathia gravidarum.

Laryngopathia gravidarum is a rare complication during pregnancy which often is associated with pre-eclampsia. In the literature different degrees of the disease are described which range from simple hoarseness to dangerous states of extreme shortage of air. Based on several cases seen in recent years we discuss the association with pre-eclampsia and document for the first time photographically how quickly morphological and functional findings disappear after the end of pregnancy.

[The tumor marker CA 15-3 in breast cancer in serum and cell compartments as an additional prognostic criterion]. / Der Tumormarker CA 15-3 beim Mammakarzinom in Serum und Zellkompartimenten als ein zusätzliches prognostisches Kriterium.

In 86 woman patients having a histologically confirmed carcinoma of the breast we examined during primary treatment the CA 15-3 data in the compartments serum, cytosol and a membrane fraction. Low CA 15-3 levels in the serum combined with high concentrations in cytosol and the membrane fraction were associated with a good prognosis, whereas a poor prognosis was seen in case of high serum values and simultaneously low values in the cytosol and the membrane fraction. Hence, it seems that prognoses of the future course of the disease are possible if the CA 15-3 values are simultaneously determined in the serum, in cytosol and in a membrane fraction.

[Involvement of pelvic lymph nodes in ovarian cancer]. / Befall der pelvinen Lymphknoten beim Ovarialkarzinom.

In contrast to earlier operating standards some authors have in the past few years, also removed pelvic lymphnodes when ovarian cancer was diagnosed. From 26 of our patients suffering from ovarian cancer, one third proved to have positive lymphnodes, when pelvic lymphonodectomy was carried out. Our data, along with-data from other authors, were reviewed and included in a statistical evaluation.

Lack of coagulation defects after the intraamniotic instillation of ethacridine (Rivanol) for second trimester abortion.

Second trimester abortion was induced by the intraamniotic infusion of ethacridine. Coagulation studies revealed no change in 10 cases. It is felt that the intraamniotic use of ethacridine is probably safe.

PIP: Coagulation assays in 10 women in whom 2nd-trimester abortion was induced through intra-amniotic infusion of ethacridine (Rivanol) suggested a lack of negative side effects. The mean gestational age of the study subjects was 22 weeks. Platelet count, thrombin time, partial thromboplastin time, and prothrombin time were measured in serum samples collected before and 12, 36, and 60 hours after ethacridine instillation. Also measured were soluble fibrin monomer complexes and Factors V, VII, X, and XII. In 9 of the 10 women, labor was induced by 1 dose of ethacridine and a dead fetus was expelled; the 10th woman required a 2nd instillation. The average duration of labor was 2.5 hours (range 0.5-5.0 hours) and induction-to-abortion time averaged 38 hours (range 31-47 hours). All coagulation measures were within normal limits before abortion induction and were not significantly influenced by ethacridine administration at any of the time intervals studied. Of particular interest was the lack of evidence of disseminated intravascular coagulation--a side effect of intra-amniotic instillation of hypertonic saline. The injection of ethacridine also seems to cause less pain than hypertonic saline, hypertonic glucose, or prostaglandin in F2 alpha.

[Dissecting aneurysm--a rare but severe complication of pregnancy]. / Das Aneurysma dissecans--eine seltene aber schwere Komplikation der Schwangerschaft.

A case of aortic dissection at 37 weeks of gestation is presented with demonstration of angiographic and pathological findings. A review of clinical and pathological literature suggests, that rupture of aortic dissecting aneurysms occurs more frequently in women being pregnant than in non-pregnant women of the same age. Women with cardial malformations, coarctatio aortae, Marfan's syndrome and hypertension are at increased risk. Ultrasound scans of heart and thoracic aorta may lead to an early diagnosis in pregnancy. Intrauterine fetal asphyxia and death may be an early symptom due to partial obliteration of Aa. iliacae internae and ovaricae.

[Digital roentgen video image processing for target calculation in stereotactic neurosurgery]. / Digitale Röntgenvideobildverarbeitung für die Zielpunktberechnung in der stereotaktischen Neurochirurgie.

The basic methods for calculating targets in stereotactic cerebral operations, using radiography or CT sections for special operations, can now be extended by a new method, depending on image generating system from a digital x-ray video chain. A micro-computer was used in order to calculate image measurements, angulation of the apparatus and documentation of the surgical procedures.

Digital radiography for target point evaluation in stereotactic neurosurgery.

Today, the usual target point evaluation during stereotactic operations using planar X-ray films can be supplemented by digital video storage. The picture-delivering system is a digital X-ray video chain which replaces the X-ray film. Evaluation of target point coordinates as well as parameters of electrode approach and positioning are determined by a microcomputer. Such an inexpensive system is described.

[A compact table computer (data tablet digitizer) system for calculation of target points in stereotactic neurosurgery (author's transl)]. / Ein kompaktes Tischrechnersystem zur Zielpunktsberechnung in der stereotaktischen Neurochirurgie.

The authors describe a compact computed calculator system which allows a fast and secure destination of the target point during stereotaxic operations.