Assuntos
Encéfalo/metabolismo , Diabetes Mellitus Experimental/metabolismo , Diabetes Mellitus Experimental/radioterapia , Rim/metabolismo , Terapia com Luz de Baixa Intensidade/métodos , Lisofosfatidilcolinas/metabolismo , Animais , Encéfalo/efeitos da radiação , Relação Dose-Resposta à Radiação , Rim/efeitos da radiação , Masculino , Especificidade de Órgãos , Dosagem Radioterapêutica , RatosAssuntos
Acetilcolina/farmacologia , Encéfalo/metabolismo , Glicoesfingolipídeos/metabolismo , Membranas Artificiais , Fosfolipídeos/metabolismo , Animais , Bovinos , Glicoesfingolipídeos/química , Técnicas In Vitro , Transporte de Íons/efeitos dos fármacos , Bicamadas Lipídicas/química , Bicamadas Lipídicas/metabolismo , Modelos Biológicos , Permeabilidade , Fosfolipídeos/química , TermodinâmicaRESUMO
The effect of low-energy infrared laser irradiation on the phospholipid pool, lipid peroxidation, and superoxide dismutase activity in the brain of white rats was studied in experimental ischemia, reperfusion, and acute edema. These models are characterized by oxidative stress; the contents of tri- and diphosphoinositides and sphingomyelins were lowered, whereas the levels of phosphatidylserine and phosphatidylethanolamine did not change, and the amount of phosphatidylcholine was increased. In acute brain edema, the contents of hydroperoxides and malonic dialdehyde in enzymatic and nonenzymic lipid peroxidation systems were increased in mitochondrial and microsomal fractions and the level of arachidonic acid was significantly elevated. Infrared laser irradiation contributes to the correction of the changes in the phospholipid pool; laser irradiation lowered the increased levels of hydroperoxides and malonic dialdehyde and elevated superoxide dismutase activity in the brain during ischemia, reperfusion, and acute edema of the brain. The data suggest that low-energy infrared laser irradiation has certain neuroprotective activity in various types of oxidative stress including ischemia, reperfusion, and acute edema of the brain.