RESUMO
Iron deficiency anemia and hyperlipidemia are common public health problems in Turkey. The connection between iron and lipid metabolisms has not been clarified yet. The aim of the study was to determine the effect of iron deficiency on carnitine and lipid metabolism. Study group was consisted of 70 children (mean age 14.7 +/- 1.3 months) suffering from iron deficiency anemia and 20 healthy children (mean age 13.7 +/- 1.2 months) attended to outpatient clinics of Cumhuriyet University, Sivas were enrolled the study as the control group. Assessments of serum free carnitine concentrations, total triglyceride, total cholesterol and VLDL levels were made in both groups. The mean serum free carnitine concentration was significantly lower than the control group (18.9 +/- 0.43 nmol/ml and 45.9 +/- 1.47 nmol/ml respectively, t = 17.5 p < 0.01). Results of our study also indicated higher serum total triglyceride, total cholesterol and VLDL levels in iron deficient patients than the healthy controls. Regression analyses indicated a negative correlation between serum free carnitine and total triglyceride levels in iron deficient patients. This study confirms that iron deficiency anemia may be linked to the endogenous carnitine synthesis in pediatric age group, and thus hyperlipidemia appears to be a risk factor for premature cardiovascular diseases.
Assuntos
Anemia Ferropriva/fisiopatologia , Carnitina/metabolismo , Metabolismo dos Lipídeos , Triglicerídeos/sangue , Anemia Ferropriva/sangue , Anemia Ferropriva/epidemiologia , Doenças Cardiovasculares/epidemiologia , Carnitina/sangue , Estudos de Casos e Controles , Colesterol/sangue , Feminino , Humanos , Hiperlipidemias/sangue , Hiperlipidemias/epidemiologia , Hiperlipidemias/fisiopatologia , Lactente , Lipoproteínas VLDL/sangue , Masculino , Análise de Regressão , Fatores de Risco , TurquiaRESUMO
Six children suffering from epilepsy refractory to conventional anti-convulsive therapy were treated with high-dose intravenous immune globulin (IVIG) (200 mg/kg three times per week, repeated after three weeks). In four children clinical and EEG findings markedly improved, while a partial response was noted in the other cases. These results suggest that high-dose intravenous immune globulin may have a beneficial effect in the treatment of intractable epilepsy.
Assuntos
Epilepsia Generalizada/terapia , Imunoglobulinas Intravenosas/uso terapêutico , Adolescente , Criança , Pré-Escolar , Eletroencefalografia , Epilepsia Generalizada/imunologia , Epilepsia Generalizada/fisiopatologia , Feminino , Humanos , Imunoglobulinas Intravenosas/farmacologia , Masculino , TurquiaRESUMO
Achalasia is a motility disorder of the esophagus characterized by absence of normal peristalsis and failure of relaxation of the lower esophageal sphincter. Among the most common clinical findings are vomiting and weight loss. Roentgenographically, a narrowed gastroesophageal junction and dilated esophagus are observed. This condition is uncommon in children. Here a seven-year old female patient with achalasia is reported.
