RESUMO
In work antiradical activity of vitamins and flafonoids in relation to hydroxyl radical is established. The most antiradical activity is established for flavonoids quercetin, routin, daidzein, biochanin A and luteolin-7glucosid, Among vitamins of group in the most antiradical activity have shown vitamins B12, B2, B5, Bc. In group of fat-soluble vitamins ascorbic palmitat, vitamin K1, vitamin A and beta-carotin have shown activity above, than a known antioxidant vitamin E. The carried out work allows to draw a conclusion that antiradical activity in the relation hydroxyl radical shows the broad audience of vitamins that probably is one of aspects of their therapeutic action.
Assuntos
Antioxidantes/farmacologia , Flavonoides/farmacologia , Antioxidantes/metabolismo , Flavonoides/metabolismo , Genisteína/metabolismo , Genisteína/farmacologia , Glucosídeos , Radical Hidroxila/metabolismo , Isoflavonas/metabolismo , Isoflavonas/farmacologia , Luteolina , Quercetina/metabolismo , Quercetina/farmacologia , Vitaminas , beta Caroteno/metabolismo , beta Caroteno/farmacologiaRESUMO
A group of patients with occupational disease and female sewing-machine operators were medically examined with a broad set of biochemical techniques aimed at the detection of metabolic disorders in the locomotor system tissues. Noninflammatory dystrophic changes were found. The muscular component was dominating in comparison with the osseous one in the genesis of the degenerative dystrophic processes, which manifested in the clinical course. Laboratory manifestations were revealed related to the lowered energy supply and oxygenation of the skeleton muscles in patients with neuromuscular and osteo-muscular++ syndromes. The metabolic disorders were diagnosed at the early stages of myalgia.