Effective anti-cancer property of Pouteria sapota leaf on breast cancer cell lines.

Natural products are vital in drug discovery and the search for anticancer agents has been significant importance to the researchers for a long time. In the present study, aqueous leaf extract of Pouteria sapota (P.sapota) was evaluated for its cytotoxic activity. The leaf extract was preliminarily screened for antioxidant activity using DPPH method for Radical Scavenging Activity, Hydrogen Peroxide Scavenging Activity and Reducing Power Activity. Further, the aqueous leaf extract was screened for cytotoxic activity against breast cancer cell lines (MCF-7) in vitro. The results of the study showed that aqueous extract of the P.sapota leaf was rich in phytochemicals, antioxidant activity and showed a significant anti-cancer activity against tested MCF-7 cell lines. The present study was designed to evaluate the anticancer potential of P.sapota leaf. The antioxidants present in P.sapota have strong cytotoxic activity suggests that it can be considered for anti-cancer treatment.

An unusual novel anti-oxidant dibenzoyl glycoside from Salvinia natans.

An unusual novel and significant anti-oxidant 1,2-dibenzoyl glycoside, natansnin (1), has been isolated from Salvinia natans. The structure of 1 was established by the study of NMR and CD spectral data.

Ultrasonic studies on lamivudine: beta-cyclodextrin and polymer inclusion complexes.

The aim of the present study is to enhance the solubility and stability of drugs in addition of water-soluble polymer and carbohydrate complexes. The data show that the polymer polyvinyl alcohol (PVA) interacts with the free Lamivudine and with the Lamivudine; beta-cyclodextrin (beta-CD) inclusion complex, in both cases with particular intermolecular interaction was studied using ultrasonic technique under different concentrations at a temperature 303 K. Consequently, the reason of this study was to improve the biological performance of the drug through enhancing its solubility and stability. The binary and ternary mixtures prepared inclusion complexes of Lamivudine in beta-CD and PVA. The presence of PVA, changes the drug: beta-CD interaction, a Lamivudine: beta-CD: PVA complex was formed. In addition, the presence of PVA produces a strong increase in the binding constant at a particular concentration (1.25%). In the ternary complex, the Lamivudine is wrapped at both ends for the beta-CD. In this complex, the polymer seems to act as a bridge between both beta-CD molecules that bind the Lamivudine.