[On the temperature sensitivity of multiple sclerosis patients (author's transl)]. / Zur Temperaturempfindlichkeit von Multiple-Sklerose-Kranken.

Aggravation of neurological symptoms in MS patients in heating is well known. This phenomenon is explained by the change of conduction in demyelinated nerve fibers. In raised temperature conduction block occurs. The threshold of conduction block dependent on temperature, is probably proportional to the degree of demyelination. It is possible to inhibit this effect by tyrosin. This model may present a view to a part of neurophysiological mechanisms of MS, on which we possibly can take therapeutical influence. By way of a questionnaire 125 MS patients were asked about changes of their symptoms in heating or cooling. 93% had marked sensitivity to heating. In 90% worsening of neurological symptoms or of general feeling occured in a hot bath. On the other hand about half the patients reported improvement in a cold bath. Therefore we suggest, that a noticeable part of neurological deficit is reversible, if we were able to raise the threshold of conduction block, which depends on temperature, ph, electrolytes and neurotransmitters.

[Experimental study on the lymphatic and cerebrocervical drainage and changes therein caused by ultrasound (author's transl)]. / Tierexperimentelle Untersuchungen zur Beeinflussung der lymphatischen cerebro-cervicalen Drainagebahn durch Ultraschall

After indian ink or ferritin are introduced into the cerebral hemispheres or subdural space these substances can be found in the deep cervical lymph nodes. The transport of these substances can be enhanced and accelerated by the treatment of deep cervical lymph nodes by ultrasound. Treatment of the paravertebral region with ultrasound after the introduction of ferritin or indian ink subdurally is followed by the appearance of these substances in the suprarenal gland, the testis, epididymis and the prostate gland where they are conveyed by the lymphatic pathways. Thirty minutes after the injection of ferritin into an afferent lymphatic channel of a deep cervical lymphatic node pretreated with ultrasound, ferritin can be found in the pia and arachnoid membranes of the cerebral hemispheres. Ultrasound treatment of the cervical lymph nodes not only seems to enhance the drainage of this substance from the brain but if the dose of ultrasound is high the direction of the lymphatic flow may be reversed.