[Radionuclide evaluation of renal function in essential hypertensive patients with chronic kidney disease].

AIM: To carry out radionuclide evaluation of renal function in patients with arterial hypertension (AH) and chronic kidney disease (CKD). SUBJECTS AND METHODS: Thirty-one AH patients with CKD were examined using dynamic nephroscintigraphy. A control group consisted of 8 CKD patients without AH. RESULTS: The scintigraphic findings reflected statistically significant differences in renal secretory and excretory functions depending on the level of glomerular filtration rate (GFR) decrease in AH patients with CKD. If GFR was 30-59 ml/min, there was a deceleration in the secretory phase in the histogram; but when it was lower than 30 ml/min, the secretory function tended to accelerate, which appeared as a 3-fold reduction in achieving the peak radio tracer concentration (p < 0.001). CONCLUSION: Dynamic nephroscintigraphy can detect early renal secretory and excretory dysfunctions and it is of prognostic value in assessing renal dysfunction, which necessitates early drug correction of revealed disorders.

[Experience with ebrantil used in patients with resistant arterial hypertension in chronic kidney disease].

AIM: To evaluate the clinical efficacy of ebrantil used in patients with resistant arterial hypertension (RAH) in Stage III-V chronic kidney disease (CKD). SUBJECTS AND METHODS: Sixty-five patients with Stage III-V CKD and RAH (systolic blood pressure (SBP) 215.7 +/- 4.0 mm Hg and diastolic blood pressure (DBP) 114.6 +/- 2.3 mm Hg) were followed up. The patients received intravenous ebrantil (urapidil) in a dose of 25 mg for 5 days and then were switched to its oral use as 30-60-mg capsules twice daily for 12 weeks. RESULTS: The intravenous infusion caused a significant fall in SBP and DBP by 23.6 and 16.7%, respectively, within 60-90 min. A steady-state antihypertensive effect was achieved on days 5-7 (SBP and DBP was lowered to 146.8 +/- 6.1 and 95.6 +/- 5.3 mm Hg, respectively; p < 0.05). After 12 weeks of the therapy, SBP was 144.4 +/- 6.3 mm Hg and DBP was 93.3 +/- 4.1 mm Hg (p < 0.05). CONCLUSION: The use of ebrantil in patients with CKD and RAH produces an effective BP without marked adverse reactions.

[The methodological aspects of identifying the etiological significance of anthropogenic pollution in the genesis of chronic bronchitis]. / Metodicheskie aspekty identifikatsii étiologicheskoi znachimosti antropogennykh zagriaznenii v geneze khronicheskogo bronkhita.

The paper is concerned with multifactorial assessment of the air anthropogenic contamination effect on development of chronic nonspecific pulmonary diseases, chronic bronchitis (CB) in particular. Methodological approaches to identify etiological significance of anthropogenic effects in CB genesis include measurements of the air contaminants, calculation of the total contamination index, selection of the study and control territories, analysis of medical documents, conduction of wide-scale medical examinations. CB developing in the conditions of the above contamination is characterized by obstructions, bronchospastic components, other separate or systemic disorders.