Estudio de la eficacia del implante intravítreo de dexametasona en el edema macular pseudofáquico. Resultados preliminares / Study of the effect of intravitreal dexamethasone implant in pseudophakic macular edema. Preliminary

OBJETIVO: Estudiar la eficacia del implante intravítreo de dexametasona (Ozurdex) en el tratamiento del edema macular (EMQ) pseudofáquico. MATERIAL Y MÉTODOS: Se ha realizado un estudio descriptivo observacional retrospectivo de un periodo de un año de duración (desde el 1 de enero de 2013 hasta el 31 de diciembre del 2013) sobre todos aquellos pacientes con EMQ pseudofáquico tratados con dexametasona intravítrea en el Hospital Universitario de La Ribera. Las variables a estudio son la agudeza visual (AV), el espesor macular y el tiempo de duración del efecto del tratamiento. RESULTADOS: Los resultados preliminares obtenidos muestran una disminución del espesor macular de 83,75 μ de media, comparando la media de los valores previos al tratamiento (414 μ) y los de un mes tras el tratamiento (330,25 μ). La AV aumentó, con una AV media pretratamiento de 0,3 mientras que la AV media al mes y a los 3 meses de tratamiento fue de 0,575. La media de la duración del efecto fue de 3,5 meses. CONCLUSIONES: El implante intravítreo de dexametasona (Ozurdex) es un posible tratamiento para el síndrome de Irvine-Gass, dado que reduce el espesor macular y mejora la AV de estos pacientes

OBJECTIVE: To evaluate the efficacy of intravitreal dexamethasone implant on the treatment of pseudophakic macular edema (PME). MATERIAL AND METHODS: A retrospective, observational, descriptive study was conducted on 4 patients who received an intravitreal injection of dexamethasone implant due to PME in the period from 1st January 2013 to 31st December 2013 in the Hospital Universitario de La Ribera (Alzira, Valencia, Spain). A complete ophthalmic examination was performed on these patients. Best-corrected visual acuity (BCVA), macular thickness), and duration of the effect of the treatment were studied. RESULTS: At baseline, the mean MT was 414 μm. After dexamethasone implant, mean values of MT decreased to 330.25 μm at month one. The mean change from baseline MT was 83.75 μm. The baseline mean BCVA was 0.3 and improved to 0.575 at month one and 3. The mean duration of the effect of the treatment was 3.5 months. CONCLUSIONS: Intravitreal dexamethasone implant is a possible treatment for Irvine-Gass syndrome as it improved visual acuity and reduced the macular thickness of these patients

[Study of the effect of intravitreal dexamethasone implant in pseudophakic macular edema. Preliminary]. / Estudio de la eficacia del implante intravítreo de dexametasona en el edema macular pseudofáquico. Resultados preliminares.

OBJECTIVE: To evaluate the efficacy of intravitreal dexamethasone implant on the treatment of pseudophakic macular edema (PME). MATERIAL AND METHODS: A retrospective, observational, descriptive study was conducted on 4 patients who received an intravitreal injection of dexamethasone implant due to PME in the period from 1st January 2013 to 31st December 2013 in the Hospital Universitario de La Ribera (Alzira, Valencia, Spain). A complete ophthalmic examination was performed on these patients. Best-corrected visual acuity (BCVA), macular thickness), and duration of the effect of the treatment were studied. RESULTS: At baseline, the mean MT was 414µm. After dexamethasone implant, mean values of MT decreased to 330.25µm at month one. The mean change from baseline MT was 83.75µm. The baseline mean BCVA was 0.3 and improved to 0.575 at month one and 3. The mean duration of the effect of the treatment was 3.5 months. CONCLUSIONS: Intravitreal dexamethasone implant is a possible treatment for Irvine-Gass syndrome as it improved visual acuity and reduced the macular thickness of these patients.

Comment on "Rapid uplift of the Altiplano revealed through 13C-18O bonds in paleosol carbonates".

Based on stable isotope measurements, Ghosh et al. (Reports, 27 January 2006, p. 511) concluded that the Bolivian Altiplano uplifted 3 to 4 kilometers between approximately 10.3 and approximately 6.7 million years ago as a result of gravitational loss of dense lithosphere. This result stands at odds with current geological knowledge of the Central Andes, and we propose a test for the reliability of the paleoaltimetry method.

Low risk of contrast nephropathy in high-risk patients undergoing spiral computed tomography angiography with the contrast medium iopromide and prophylactic oral hydratation.

BACKGROUND: Spiral computed tomography angiography (CTA) is a sensitive and specific technique for visualizing renal arteries and diagnosing renal artery stenosis (RAS). Whether spiral CTA is associated with increased risk of contrast nephropathy (CN) in patients with impaired renal function is unknown. METHODS: We prospectively studied 50 patients with chronic renal insufficiency (serum creatinine concentration greater than 1.58 mg/dl) who underwent spiral CTA with iopromide, a nonionic, low-osmolar contrast agent. Fourteen patients had diabetes mellitus. Patients were encouraged to drink 1 l of water 12 hours before and 2 l over 24 hours after the procedure. The presence of CN was defined by an increase of 20% or more in the baseline serum creatinine level within or 72 hours after administration of the radio-contrast agent. RESULTS: In the entire group, mean serum creatinine levels increased significantly from 2.92 +/- 1.39 to 3.06 +/- 1.55 mg/dl (p = 0.02) and mean creatinine clearance decreased from 29.8 +/- 12.9 to 28.9 +/- 12.8 ml/min (p = 0.009) 72 h after administration of the contrast medium. Two patients experienced an increase in serum creatinine level of 20%. Renal function returned to baseline within seven days in the 2 patients. Absolute changes in creatinine clearance after the administration of radiocontrast medium were similar in nondiabetic and diabetic patients and in the subgroup of patients, with a baseline serum creatinine of < 3 mg/dl and > or = 3 mg/dl. CONCLUSIONS: In patients with chronic renal insufficiency, spiral CTA performed with iopromide, a nonionic, low-osmolar contrast medium and a prophylactic oral hydratation, is a minimally invasive technique with low risk of contrast nephropathy.

Narcolepsia en niños / Narcolepsy in children

Introducción. La narcolepsia es un trastorno neurológico caracterizado por somnolencia excesiva durante el día, con episodios recurrentes e irresistibles de sueño, que asocia en las formas completas cataplejía, alucinaciones hipnagógicas y parálisis del sueño. La incidencia comunicada en el adulto es 4-10/ 10.000. Un porcentaje considerable de adultos reconoce su inicio antes de los 15 años de edad. Es imprescindible la confirmación neurofisiológica de los períodos cortos de inicio de sueño REM. Caso clínico. Varón de 11 años, con hipersomnolencia diurna, trastorno de conducta y aumento de peso, que se evaluó en Unidad de Trastornos del Sueño mediante polisomnografía y test de latencias múltiples, confirmándose la sospecha de narcolepsia. Conclusiones. La narcolepsia es una enfermedad de inicio en la infancia y que habitualmente pasa desapercibida o erróneamente diagnosticada y tratada. Existen actualmente criterios válidos para identificar y diagnosticar a los niños con el trastorno. El tratamiento de estos pacientes debe orientarse a la adaptación del entorno al niño y la prevención de problemas psicosociales que origina, dada la pobre respuesta a los fármacos empleados (AU)

[Narcolepsy in children]. / Narcolepsia en niños.

INTRODUCTION: Narcolepsy is a neurological disorder characterized by excessive somnolence during the daytime, with recurrent, irresistible episodes of sleepiness. The complete forms are associated with cataplexy, hypnagogic hallucinations and sleep paralysis. The incidence reported in adults is 4 10/10,000. A considerable proportion of adults consider their disorder to have started before the age of 15 years. It is essential to have neurophysiological confirmation of the short period of the onset of REM sleep for diagnosis. CLINICAL CASE: An 11 year old boy with diurnal hypersomnolence, behavior disorder and weight gain. He was evaluated in the Sleep Disorder Unit by polysomnography and the multiple latency test, which confirmed the suspicion of narcolepsy. CONCLUSIONS: Narcolepsy is a disorder which starts during childhood and usually goes unnoticed or is erroneously diagnosed and treated. At the present time there are valid criteria for the identification and diagnosis of children with this disorder. Treatment of these patients should be orientated towards adaptation of the environment to the child and prevention of the psychosocial problems which may be caused by this disorder, in view of the poor response to the drugs used.

[Accident and emergency department inappropriate utilization. An evaluation with explicit criteria]. / Utilización inadecuada de un servicio de urgencias hospitalario. Una evaluación con criterios explícitos.

BACKGROUND: Several studies have shown a growth in the number of visits to accident and emergency (A&E) hospital departments with a high proportion of inappropriate utilization. Methods to identify improper use based on implicit criteria limit the comparisons between hospitals. The aim of this study is to know the proportion of inappropriate attendance's in an A&E department and their associated factors, using a method with objective criteria. METHODS: An instrument based on diagnosis-independent explicit criteria was used to identify inappropriate visits in a random sample of 1845 14-year-old greater patients attended to A&E medical services, and the factors associated with improper demand were analysed. RESULTS: The proportion of inappropriate attendance's was of the 26,8% (495/1. 845). The unadjusted analysis show that the smaller age, absence of comorbidity, spontaneous visit and some diagnostic groups (diseases of the skin, muscle-skeletal, mental, and bad defined symptoms) were associated to a greater proportion of improper use. Upon adjusting the variables through logistics regression, the age, associated pathology, the spontaneous attendance's and diagnostic groups, maintained the association with improper use, but other variables as woman gender, and night hours were also associated to inappropriate utilization. CONCLUSIONS: At least the fourth part of the attendance's in the A&E medical services do not require urgent attention. Inappropriate utilization is associated to characteristic of the patient and the attended process.

[Joubert syndrome. Study of a new case and review of the literature]. / Síndrome de Joubert. Estudio de un nuevo caso y revisión de la literatura.

A two-year old male affected by Joubert Syndrome (cerebellar vermix agenesis, mental retardation, respiratory rythm disturbs, ataxia and abnormal eye movements) is reported. A review of literature of fourteen previous cases is done. Early diagnosis of this syndrome is very important for later prognosic and genetic advice. Authors point out the usefulness of CT scan for diagnosis.