RESUMO
The converting enzyme inhibitor CGS 13928C was evaluated in 15 healthy male volunteers. First the efficacy of a single oral dose of 0.5, 1, 2 or 5 mg in antagonizing the pressor response to exogenous angiotensin I was tested with continuous monitoring of the blood pressure and heart rate by an intraarterial catheter. CGS 13928C 1, 2 and 5 mg consistently reduced the response to angiotensin within 2 to 3 h and for a period exceeding the 4 h of monitoring. The 2 mg dose was hardly more effective than 1 mg and 5 mg did not further enhance the blockade. Subsequently, plasma renin and converting enzyme activity, angiotensin I, angiotensin II and aldosterone were measured serially before and up to 72 h following oral administration of either 1 mg (n = 7) or 2 mg (n = 8) CGS 13928C. As expected, plasma renin activity and angiotensin I rose, while plasma converting enzyme activity, angiotensin II and aldosterone fell following both doses of the drug. No side-effects occurred. In normal volunteers CGS 13928C is an effective and extremely potent, orally active converting enzyme inhibitor.
Assuntos
Inibidores da Enzima Conversora de Angiotensina , Pressão Sanguínea/efeitos dos fármacos , Indóis/farmacologia , Sistema Renina-Angiotensina/efeitos dos fármacos , Adulto , Angiotensina I/farmacologia , Relação Dose-Resposta a Droga , Avaliação de Medicamentos , Frequência Cardíaca/efeitos dos fármacos , Humanos , Masculino , Pressorreceptores/efeitos dos fármacos , Fatores de TempoRESUMO
Most urinary fistulae of obstetric origin involve the bladder. The ureter is rarely injured. The authors report three cases of uretero-uterine fistulae, an entity accounting for 1.6% of all urinary fistulae resulting from obstetric trauma. Diagnosis and management are discussed with reference to 19 cases of uretero-uterine fistulae reported in the literature.
