RESUMO
A systematic review of the studies where HIPEC combined with cytoreductive surgery was used in patients with primary advanced ovarian cancer was performed to understand is there a role for this treatment modality not only in recurrent but in primary advanced ovarian cancer. The results are controversial but there is a strong trend for improvement of the long-term outcomes of patients with primary advanced ovarian cancer after HIPEC.
Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Quimioterapia do Câncer por Perfusão Regional , Procedimentos Cirúrgicos de Citorredução/métodos , Hipertermia Induzida/métodos , Neoplasias Ovarianas/mortalidade , Neoplasias Ovarianas/terapia , Terapia Combinada , Feminino , Humanos , Metanálise como Assunto , Prognóstico , Taxa de SobrevidaRESUMO
Rationale and feasibility of isolated pelvic perfusion (IPP) as a high-tech treatment modality for patients with pelvic malignancies was studied and analyzed based on the systematic review of the literature. Indications, techniques and regimens of IPP are reviewed. There is a focus on anticancer agents for IPP and methods of complete vascular isolation of the perfusated region. Data on the short- and long-term outcome of patients after IPP are presented. To the best of authors' knowledge this is the first Russian article regarding application of IPP in oncology practice.
Assuntos
Quimioterapia do Câncer por Perfusão Regional , Neoplasias do Colo/tratamento farmacológico , Neoplasias Pélvicas/tratamento farmacológico , Neoplasias do Colo do Útero/tratamento farmacológico , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Neoplasias do Colo/patologia , Feminino , Humanos , Recidiva Local de Neoplasia/tratamento farmacológico , Recidiva Local de Neoplasia/patologia , Neoplasias Pélvicas/patologia , Pelve/patologia , Federação Russa , Neoplasias do Colo do Útero/patologiaRESUMO
AIM: To explore in a model experiment the capability of the developed software for 3D- ultrasound imaging of tumors in the pelvic tissue phantom to steer a brachytherapy needle using 6-axis robotic arm. MATERIALS AND METHODS: The experiment employed a six-axis robotic arm with a device for moving the needle, a phantom with a tumor model and ultrasound scanner with biplane transducer. Controlled by the developed software, the robotic arm automatically inserted the needle in the phantom. At all stages of inserting the needle, its position in the phantom was continuously tracked using data obtained by the ultrasonic transducer. RESULTS: The software was developed and tested for intra-tissue ultrasound imaging to steer a brachytherapy needle using US-scanner coupled with the robotic system providing 3D tumor modeling within the pelvic tissue phantom. In the course of the operation, the program corrects the existing model using current US images considering any shifting and swelling of the prostate. CONCLUSION: The model experiment proved the operational capability of the proposed method of 3D tumor modeling within the pelvic tissue phantom and tracking needle movement in the phantom in real time using US scanner coupled with a robotic system for brachytherapy. Further development of the software, providing ultrasound image processing and automatically correcting the brachytherapy needle trajectory, will complete preclinical studies of a robotic arm and warrant clinical trials.
