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1.
Clin Oral Investig ; 28(7): 377, 2024 Jun 17.
Artigo em Inglês | MEDLINE | ID: mdl-38884817

RESUMO

OBJECTIVES: The pathogenesis of oral cavity cancers is complex. We tested the hypothesis that oral microbiota dysbiosis is associated with oral cavity cancer. MATERIALS AND METHODS: Patients with primary oral cavity cancer who met the inclusion and exclusion criteria were included in the study. Matching healthy individuals were recruited as controls. Data on socio-demographic and behavioral factors, self-reported periodontal measures and habits, and current dental status were collected using a structured questionnaire and periodontal chartings. In addition to self-reported oral health measures, each participant received a standard and detailed clinical examination. DNA was extracted from saliva samples from patients and healthy controls. Next-generation sequencing was performed by targeting V3-V4 gene regions of the 16 S rRNA with subsequent bioinformatic analyses. RESULTS: Patients with oral cavity cancers had a lower quality of oral health than healthy controls. Proteobacteria, Aggregatibacter, Haemophilus, and Neisseria decreased, while Firmicutes, Bacteroidetes, Actinobacteria, Lactobacillus, Gemella, and Fusobacteria increased in oral cancer patients. At the species level, C. durum, L. umeaens, N. subflava, A. massiliensis, and V. dispar were significantly lower, while G. haemolysans was significantly increased (p < 0.05). Major periodontopathogens associated with periodontal disease (P. gingivalis and F.nucleatum) increased 6.5- and 2.8-fold, respectively. CONCLUSION: These data suggested that patients with oral cancer had worse oral health conditions and a distinct oral microbiome composition that is affected by personal daily habits and may be associated with the pathogenicity of the disease and interspecies interactions. CLINICAL RELEVANCE: This paper demonstrates the link between oral bacteria and oral cancers, identifying mechanistic interactions between species of oral microbiome.


Assuntos
Disbiose , Neoplasias Bucais , Saliva , Humanos , Feminino , Masculino , Pessoa de Meia-Idade , Disbiose/microbiologia , Neoplasias Bucais/microbiologia , Saliva/microbiologia , Estudos de Casos e Controles , Inquéritos e Questionários , Idoso , Microbiota , Adulto , RNA Ribossômico 16S/análise , Saúde Bucal
2.
Int J Environ Health Res ; 31(1): 20-33, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31155923

RESUMO

The main purpose of this study was to identify the concentrations of naturally occurring radionuclides (226Ra, 232Th and 40K) and some metals (Fe, Ni, Cu, Zn, Pb and Cd) in tooth samples collected from humans living in the Rize province of Turkey. It was found that the activity concentrations ranged from 8.1 to 114.51 Bq kg-1 for 226Ra, from 10.44 to 97.3 Bq kg-1 for 232Th and from 14.53 to 489.27 Bq kg-1 for 40K. The mean activity concentration values of 226Ra and 232Th in tooth samples were higher than the average world values for bones. Furthermore, when the metal concentrations were examined, there was no regular increase or decrease according to age or sex. The results of the metal analysis on the tooth samples were compared with the results of similar studies and were generally found to be consistent.


Assuntos
Exposição Ambiental/análise , Poluentes Ambientais/análise , Metais Pesados/análise , Radioisótopos/análise , Dente/química , Adolescente , Adulto , Criança , Monitoramento Ambiental , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Turquia , Adulto Jovem
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