Serum thyroid hormones levels are significantly decreased in septic neonates with poor outcome.

The aim of this prospective study was to investigate the effects of thyroid hormone levels on the sepsis criteria and mortality in septic newborns. This study was performed at the Firat University Hospital Neonatal Intensive Care Unit. A group of septic newborns and a control group of healthy non-infected newborns were evaluated. Blood samples were obtained at onset from septic and healthy newborns and at 10th day of the antibiotic therapy from only septic newborns, and thereafter serum total T(3) (TT(3)), total T(4) (TT(4)), and TSH levels were determined. A total of 292 newborns were included in the study. Serum TT(3) levels at onset and at 10th day of the antibiotic therapy were 163.8±63.4 and 178.3±33.1 ng/dl, TT(4) levels were 6.9±2.2 and 11.0±2.6 mg/ml, and TSH levels were 3.8±2.1 and 4.0±2.5 µU/ml, respectively in septic newborns. Serum TT3 levels were 180.3±47.6 ng/dl, TT(4) levels were 10.9±2.3 mg/ml, and TSH levels were 4.1±2.2 µU/ml in healthy newborns. Serum TT(3), TT(4) levels of septic newborns were significantly decreased with respect to those of healthy newborns at onset and serum TT(4) levels was increased significantly after antibiotic therapy. To the best of our knowledge, this report is the first study to compare thyroid hormone levels in a large number of septic newborns and a healthy group. Our findings suggest that before and after treatment of neonatal sepsis a significant change is realized in thyroid hormone levels.

Deep soft tissue leiomyoma of the lower extremities: a case report.

Leiomyomas, which are seldom reported as occurring in the lower extremities, arise from smooth muscle cells and are chiefly classified as cutaneous, vascular (angiomyoma), and deep soft tissue leiomyomas. Somatic and gynaecologic subtypes constitute soft tissue leiomyomas. Somatic ones uncommonly arise in the deep soft tissue of the extremities. We report the case of a 49-year-old woman who presented with the primary complaint of a painful mass on the front of the superior part of the left tibialis anterior muscle. After total excision of the encapsulated mass, histopathologic evaluation revealed the characteristic appearance of leiomyoma. Clinical follow-up for 17 months assigned no evidence of local recurrence or distant metastasis. Although deep soft tissue leiomyomas of the lower extremities are rare, they should be included in the differential diagnosis of any lower extremity mass. Surgical excision provides both diagnosis and treatment and recurrence is rare.

Aryepiglottic fold and subcutaneous metastases from breast carcinoma.

We report the CT findings in a 77-year-old woman with left-sided aryepiglottic fold metastasis from breast cancer diagnosed 7 years previously. The lesion obliterated the left piriform sinus, had a lobulated contour and showed mild and heterogeneous enhancement on a post-contrast CT examination. Biopsy of the lesion revealed metastasis from poorly differentiated adenocarcinoma, compatible with metastasis of the breast carcinoma. Before detection of the laryngeal lesion, a second primary tumor in the right ovary was diagnosed. After right oopherectomy, histopathology revealed clear cell adenocarcinoma. The patient also had multiple subcutaneous metastases and bilateral cervical lymphadenopathies. Chemotherapy was applied to the patient.

Deep Soft Tissue Leiomyoma of the Lower Extremities: a Case Report.

Leiomyomas, which are seldom reported as occurring in the lower extremities, arise from smooth muscle cells and are chiefly classified as cutaneous, vascular (angiomyoma), and deep soft tissue leiomyomas. Somatic and gynae-cologic subtypes constitute soft tissue leiomyomas. Somatic ones uncommonly arise in the deep soft tissue of the extremities. We report the case of a 49-year-old woman who presented with the primary complaint of a painful mass on the front of the superior part of the left tibialis anterior muscle. After total excision of the encapsulated mass, histopathologic evaluation revealed the characteristic appearance of leiomyoma. Clinical follow-up for 17 months assigned no evidence of local recurrence or distant metastasis. Although deep soft tissue leiomyomas of the lower extremities are rare, they should be included in the differential diagnosis of any lower extremity mass. Surgical excision provides both diagnosis and treatment and recurrence is rare.