RESUMO
O COVID-19 foi uma doença que parou o mundo em meados de março de 2020 e segue com dados alarmantes até o momento, tornando necessárias propostas de medidas preventivas, dentre elas o isolamento social. O artigo tem por objetivo analisar as possibilidades de promoção do envelhecer saudável no contexto da pandemia de COVID- 19. A pesquisa refere-se a uma revisão integrativa que engloba a identificação e análise de publicações científicas acerca da promoção do envelhecer saudável diante dos desafios da pandemia de COVID-19. Foram selecionados oito (08) artigos dentre os pesquisados, que culminaram na abordagem de três categorias: relações ISOLAMENTO SOCIAL X VULNERABILIDADE DO IDOSO, SAÚDE MENTAL X COVID-19 e AÇÕES DE ENFERMAGEM PARA O ENVELHECER SAUDÁVEL, onde pôde-se entender a importância da promoção do envelhecer saudável principalmente no contexto da pandemia do COVID-19, onde o isolamento social cria barreiras na comunicação, nas atividades de vida diária e no cuidar em enfermagem.
COVID-19 was a disease that stopped the world in mid-March 2020 and continues with alarming data so far, making it necessary to propose preventive measures, including social isolation. The article aims to analyze the possibilities of promoting healthy aging in the context of the COVID-19 pandemic. The research refers to an integrative review, including the identification and analysis of scientific publications about the promotion of healthy aging in the face of the challenges of the COVID-19 pandemic. Eight (08) articles were selected from those surveyed, which culminated in the approach of three categories: SOCIAL ISOLATION X VULNERABILITY OF THE ELDERLY, MENTAL HEALTH X COVID-19, and NURSING ACTIONS FOR HEALTHY AGING, where it was possible to understand the importance of promoting healthy aging mainly in the context of the COVID-19 pandemic, where social isolation creates barriers in communication, activities of daily living, and nursing care.
Assuntos
COVID-19RESUMO
BACKGROUND: Epidermolysis bullosa simplex with muscular dystrophy (EBS-MD; OMIM #226670) is an autosomal recessive disease, characterized mainly by skin blistering at birth or shortly thereafter, progressive muscle weakness, and rarely by alopecia. EBS-MD is caused by mutations in the PLEC gene (OMIM *601282), which encodes plectin, a structural protein expressed in several tissues, including epithelia and muscle. We describe a patient affected with EBS-MD and diffuse alopecia in which we identified a novel pathogenic mutation by PCR amplification of all coding exons and exon-intron boundaries of PLEC gene, followed by bidirectional Sanger sequencing. CASE PRESENTATION: The patient, a 28-year-old female and only child of consanguineous healthy parents, was born after uneventful pregnancy. At 2 days of age, she developed skin and oral mucosal blistering, accompanied by voice hoarseness. On physical examination as an adult, we observed diffuse non-scarring alopecia on the scalp, onychodystrophy (pachyonychia) in all 20 nails, dental decay, mild dysphonia, and severe muscle atrophy mainly affecting the extremities. Neurological examination showed profoundly diminished reflexes. Mutation analysis revealed the patient to be homozygous for the novel PLEC nonsense mutation - c.7159G > T (p.Glu2387*) - located in exon 31. Thismutation predicts the lack of expression of the full-length plectin isoform. CONCLUSION: The present case appears to be the second association of EBS-MD with diffuse alopecia, both cases having different mutations involving PLEC exon 31. It remains to be elucidated whether diffuse alopecia results from PLEC mutations and/or from environmental factors.
