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Cancer Sci ; 103(12): 2102-9, 2012 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-22957919

RESUMO

Glioblastoma is a diffusely growing malignant brain tumor and among the most aggressive of all tumors. Wilms' tumor 1-associating protein (WTAP) is a nuclear protein that has been associated with regulation of proliferation and apoptosis. Although its dynamic expression and physiological functions in vascular cells have been reported, those in other cells are largely unknown. Here, we show for the first time that WTAP is overexpressed in glioblastoma. Moreover we found that WTAP regulates migration and invasion of glioblatoma cells. Specific knockdown by siRNA or overexpression by cDNA regulated migration and invasion of cancer cells. In xenograft study, WTAP overexpression made cancer cells more tumorigenic. In the investigation for its underlying mechanism, we found that the activity of epidermal growth factor receptor can be regulated by WTAP. These results reveal a novel function of WTAP and suggest its clinical application.


Assuntos
Neoplasias Encefálicas/metabolismo , Glioblastoma/metabolismo , Proteínas Nucleares/genética , Animais , Apoptose , Neoplasias Encefálicas/genética , Proteínas de Ciclo Celular , Linhagem Celular Tumoral , Movimento Celular , DNA Complementar/genética , Receptores ErbB/genética , Receptores ErbB/metabolismo , Glioblastoma/genética , Humanos , Camundongos , Transplante de Neoplasias , Proteínas Nucleares/metabolismo , Fatores de Processamento de RNA , RNA Interferente Pequeno/metabolismo , Transplante Heterólogo
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